ARHGEF19

Description		Rho guanine nucleotide exchange factor 19
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GO Annotations	Cellular Component	Cytosol
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding
	Biological Process	Regulation Of Actin Cytoskeleton Organization Wound Healing Regulation Of Small GTPase Mediated Signal Transduction Wnt Signaling Pathway, Planar Cell Polarity Pathway
Pathways		NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33339817 33547301) Apolipoprotein B levels ( 32203549) Aspartate aminotransferase levels ( 33547301) Facial morphology ( 31763980) Gamma glutamyl transferase levels ( 29403010 33339817) Initial pursuit acceleration ( 29064472) LDL cholesterol levels ( 32203549) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514)
Novel Interacting Genes		3 novel interacting genes: KLHL20 PAK5 RHOA
Interacting Genes		3 interacting genes: KLHL20 PAK5 RHOA
Entrez ID		128272
HPRD ID		10659
Ensembl ID		ENSG00000142632
Uniprot IDs		B4DN02 Q8IW93
PDB IDs		8YR7
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Apoptotic Process Angiotensin-mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Mitotic Cleavage Furrow Formation Cytoskeleton Organization Negative Regulation Of Programmed Cell Death Type II Interferon Binding Aortic Valve Formation Positive Regulation Of Vascular Associated Smooth Muscle Contraction Endothelial Tube Lumen Extension Skeletal Muscle Satellite Cell Migration Protein K33-linked Ubiquitination Beta Selection Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Bone Trabecula Morphogenesis Apolipoprotein A-I-mediated Signaling Pathway Roundabout Signaling Pathway Regulation Of Systemic Arterial Blood Pressure By Endothelin Forebrain Radial Glial Cell Differentiation Positive Regulation Of Lipase Activity Cleavage Furrow Formation Negative Regulation Of Cell Size Apical Junction Assembly Ossification Involved In Bone Maturation Negative Regulation Of Cellular Respiration Negative Regulation Of Oxidative Phosphorylation Regulation Of Modification Of Postsynaptic Actin Cytoskeleton Regulation Of Vascular Associated Smooth Muscle Contraction Positive Regulation Of Podosome Assembly Negative Regulation Of Motor Neuron Apoptotic Process Dendrite Heart Valve Formation Endothelial Tube Morphogenesis Radial Glial Cell Differentiation Regulation Of Modification Of Postsynaptic Structure Motor Neuron Apoptotic Process Regulation Of Podosome Assembly Regulation Of Motor Neuron Apoptotic Process Cellular Response To Chemokine Positive Regulation Of Systemic Arterial Blood Pressure Golgi To Endosome Transport Response To Cytokine Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Establishment Of Epithelial Cell Apical/basal Polarity Response To Peptide Organelle Organization Apical Junction Complex Establishment Of Apical/basal Cell Polarity Regulation Of Aerobic Respiration Establishment Of Monopolar Cell Polarity
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