GPC3 and FGF2

Number of citations of the paper that reports this interaction (PubMedID 12478660)
0

Data Source:
HPRD (in vivo, in vitro)

		GPC3	FGF2
Description		glypican 3	fibroblast growth factor 2
Image
GO Annotations	Cellular Component	Lysosome Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Cell Surface Membrane Lysosomal Lumen Side Of Membrane	Extracellular Region Extracellular Space Nucleus Cytoplasm
	Molecular Function	Protein Binding Peptidase Inhibitor Activity Peptidyl-dipeptidase Inhibitor Activity	Fibroblast Growth Factor Receptor Binding Cytokine Activity Integrin Binding Protein Binding Growth Factor Activity Heparin Binding Chemokine Binding Chemoattractant Activity Identical Protein Binding Histone H3K9me2/3 Reader Activity Receptor-receptor Interaction
	Biological Process	Branching Involved In Ureteric Bud Morphogenesis Kidney Development Smoothened Signaling Pathway Negative Regulation Of Cell Population Proliferation Response To Bacterium Anatomical Structure Morphogenesis Animal Organ Morphogenesis Anterior/posterior Axis Specification Regulation Of Signal Transduction Body Morphogenesis Cell Migration Bone Mineralization Osteoclast Differentiation Lung Development Positive Regulation Of BMP Signaling Pathway Embryonic Hindlimb Morphogenesis Regulation Of Growth Cell Migration Involved In Gastrulation Positive Regulation Of Protein Catabolic Process Positive Regulation Of Endocytosis Negative Regulation Of Smoothened Signaling Pathway Positive Regulation Of Smoothened Signaling Pathway Negative Regulation Of Growth Positive Regulation Of D-glucose Import Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Canonical Wnt Signaling Pathway Coronary Vasculature Development Cell Proliferation Involved In Kidney Development Mesenchymal Cell Proliferation Involved In Ureteric Bud Development Mesonephric Duct Morphogenesis Cell Proliferation Involved In Metanephros Development Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Protein Localization To Membrane Regulation Of Non-canonical Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway	Angiogenesis Osteoblast Differentiation Branching Involved In Ureteric Bud Morphogenesis Organ Induction Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Proliferation Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Neuroblast Proliferation Chromatin Organization Transcription By RNA Polymerase II Chemotaxis Signal Transduction Ras Protein Signal Transduction Nervous System Development Neuroblast Proliferation Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Embryo Development Ending In Birth Or Egg Hatching Animal Organ Morphogenesis Glial Cell Differentiation Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Fibroblast Migration Growth Factor Dependent Regulation Of Skeletal Muscle Satellite Cell Proliferation Substantia Nigra Development Cerebellar Granule Cell Precursor Proliferation Positive Regulation Of Cerebellar Granule Cell Precursor Proliferation Neurogenesis Cell Differentiation Hyaluronan Catabolic Process Lung Development Regulation Of Cell Migration Paracrine Signaling Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Wound Healing Inner Ear Auditory Receptor Cell Differentiation Positive Regulation Of Cell Fate Specification Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Blood Vessel Endothelial Cell Migration Endothelial Cell Migration Response To Ethanol Positive Regulation Of Inner Ear Auditory Receptor Cell Differentiation Positive Regulation Of Osteoblast Differentiation Regulation Of Angiogenesis Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Retinal Cell Programmed Cell Death Behavioral Response To Ethanol Embryonic Morphogenesis Positive Regulation Of Smooth Muscle Cell Proliferation Response To Axon Injury Stem Cell Differentiation Stem Cell Development Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Positive Chemotaxis Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Cell Cycle Positive Regulation Of Cell Division Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cardiac Muscle Cell Proliferation Canonical Wnt Signaling Pathway Corticotropin Hormone Secreting Cell Differentiation Thyroid-stimulating Hormone-secreting Cell Differentiation Neuroepithelial Cell Differentiation Chondroblast Differentiation Mammary Gland Epithelial Cell Differentiation Angiogenesis Involved In Coronary Vascular Morphogenesis Negative Regulation Of Wound Healing ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Mechanical Stimulus Stem Cell Proliferation Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Lens Fiber Cell Differentiation Positive Regulation Of MiRNA Transcription Positive Regulation Of Neuroepithelial Cell Differentiation Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Positive Regulation Of Sprouting Angiogenesis Response To Wortmannin Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Lymphatic Endothelial Cell Migration Positive Regulation Of Epithelial Tube Formation Regulation Of Morphogenesis Of An Epithelium Positive Regulation Of Blood Vessel Branching Positive Regulation Of Vascular Endothelial Cell Proliferation Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Positive Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Positive Regulation Of DNA Biosynthetic Process Negative Regulation Of Stem Cell Proliferation Positive Regulation Of Stem Cell Proliferation Positive Regulation Of Stem Cell Differentiation Positive Regulation Of Endothelial Cell Chemotaxis
Pathways		Glycosaminoglycan-protein linkage region biosynthesis HS-GAG biosynthesis HS-GAG biosynthesis HS-GAG degradation Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Defective B3GALT6 causes EDSP2 and SEMDJL1 Post-translational protein phosphorylation Attachment and Entry Attachment and Entry Retinoid metabolism and transport Respiratory syncytial virus (RSV) attachment and entry RSV-host interactions	PI3K Cascade PIP3 activates AKT signaling Signaling by activated point mutants of FGFR1 Signaling by activated point mutants of FGFR3 FGFR4 ligand binding and activation FGFR1b ligand binding and activation FGFR3c ligand binding and activation FGFR1c ligand binding and activation FGFR2c ligand binding and activation FGFR2b ligand binding and activation Activated point mutants of FGFR2 Constitutive Signaling by Aberrant PI3K in Cancer POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Syndecan interactions Non-integrin membrane-ECM interactions Phospholipase C-mediated cascade: FGFR1 Phospholipase C-mediated cascade; FGFR2 Phospholipase C-mediated cascade; FGFR3 Phospholipase C-mediated cascade; FGFR4 Downstream signaling of activated FGFR1 SHC-mediated cascade:FGFR1 PI-3K cascade:FGFR1 FRS-mediated FGFR1 signaling PI-3K cascade:FGFR2 SHC-mediated cascade:FGFR2 FRS-mediated FGFR2 signaling SHC-mediated cascade:FGFR3 FRS-mediated FGFR3 signaling PI-3K cascade:FGFR3 FRS-mediated FGFR4 signaling SHC-mediated cascade:FGFR4 PI-3K cascade:FGFR4 Negative regulation of FGFR1 signaling Negative regulation of FGFR2 signaling Negative regulation of FGFR3 signaling Negative regulation of FGFR4 signaling Signaling by FGFR2 in disease Signaling by FGFR1 in disease Signaling by FGFR3 in disease FGFRL1 modulation of FGFR1 signaling RAF/MAP kinase cascade Interleukin-4 and Interleukin-13 signaling PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Signaling by FGFR2 IIIa TM Formation of intermediate mesoderm Formation of the nephric duct TGFBR3 regulates FGF2 signaling Developmental Lineage of Multipotent Pancreatic Progenitor Cells
Drugs			Sucralfate Pentosan polysulfate Heparin 1,4-Dideoxy-O2-Sulfo-Glucuronic Acid N,O6-Disulfo-Glucosamine 1,4-Dideoxy-5-Dehydro-O2-Sulfo-Glucuronic Acid ABT-510
Diseases		Heparan sulfate proteoglycan gene defects, including: Dyssegmental dysplasia, Silverman-Handmaker type; Schwartz-Jampel syndrome; Simpson-Golabi-Behmel syndrome, type 1; Omodysplasia 1; Multiple exostoses
GWAS		Educational attainment (years of education) ( 30038396) Relative hand skill ( 24068947)	A body shape index ( 34021172) Acne (severe) ( 30542056) Body mass index ( 25673413) Irritable bowel syndrome ( 24797007) Mosquito bite size ( 28199695) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for body mass index ( 25673412)
Interacting Genes		6 interacting genes: APPL1 FGF2 IGF2 PTPRS WNT3A WNT7B	33 interacting genes: API5 BBS9 CASP1 CD44 CEP57 CRYAB CSNK2A1 CSNK2A2 CSNK2B CXCL13 FGFBP1 FGFR1 FGFR3 FGFR4 FGFRL1 FURIN GPC3 GPC4 HSPG2 IL2 NRP1 PF4 PRMT1 PTX3 RPL6 RPS19 RPS6KA3 SDC1 SDC2 SDC3 SNTG1 THBS1 VTN
Entrez ID		2719	2247
HPRD ID		02074	00622
Ensembl ID		ENSG00000147257	ENSG00000138685
Uniprot IDs		B4DTD8 I6QTG3 P51654 Q53H15	D9ZGF5 P09038
PDB IDs		7ZA1 7ZAW	1BAS 1BFB 1BFC 1BFF 1BFG 1BLA 1BLD 1CVS 1EV2 1FGA 1FQ9 1II4 1IIL 2BFH 2FGF 2M49 4FGF 4OEE 4OEF 4OEG 5X1O 6L4O 8HU7 8HUE 8OM6
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cell Fate Specification Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Embryonic Placenta Morphogenesis Regulation Of Developmental Growth Canonical Wnt Signaling Pathway Embryonic Morphogenesis Osteoblast Differentiation Positive Regulation Of Cell Fate Commitment Receptor Ligand Activity Regulation Of Growth Positive Regulation Of Developmental Growth Positive Regulation Of Vascular Endothelial Cell Proliferation Positive Regulation Of Striated Muscle Tissue Development Positive Regulation Of Skeletal Muscle Tissue Development Regulation Of Collateral Sprouting Regulation Of Cell Fate Specification Regulation Of Signal Transduction Positive Regulation Of Epithelial Cell Proliferation Regulation Of Skeletal Muscle Tissue Development Regulation Of Cell Differentiation Cytokine Activity Negative Regulation Of Axon Extension Regulation Of Vascular Endothelial Cell Proliferation Positive Regulation Of Growth Chordate Embryonic Development In Utero Embryonic Development Synapse Organization Frizzled Binding Regulation Of Cell Communication Regulation Of Signaling Wnt Signaling Pathway Regulation Of Fibroblast Migration Regulation Of Striated Muscle Tissue Development Cell Development Positive Chemotaxis Regulation Of Muscle Organ Development Regulation Of Cell Fate Commitment Cell Surface Receptor Signaling Pathway Positive Regulation Of Organ Growth Non-canonical Wnt Signaling Pathway Negative Regulation Of Axonogenesis Positive Regulation Of Neural Precursor Cell Proliferation Neuron Differentiation Regulation Of Neurogenesis Regulation Of Epithelial Cell Proliferation Cellular Response To Retinoic Acid Signal Transduction Tissue Morphogenesis Hippocampus Development	Fibroblast Growth Factor Binding Cell Surface Receptor Signaling Pathway Heparin Binding Golgi Lumen Fibroblast Growth Factor Receptor Activity Cell Migration Signal Transduction Fibroblast Growth Factor Receptor Signaling Pathway Cell Motility Extracellular Region Protein Kinase CK2 Complex Cell Surface Lysosomal Lumen Regulation Of Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Identical Protein Binding Negative Regulation Of Proteolysis Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Cellular Component Organization Regulation Of Cell Population Proliferation Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Regulation Of Endothelial Cell Migration Regulation Of Signal Transduction Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Cellular Response To Growth Factor Stimulus Collagen V Binding Positive Regulation Of Signal Transduction Negative Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Cell Population Proliferation Regulation Of Proteolysis Positive Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Apoptotic Signaling Pathway Regulation Of Endothelial Cell Proliferation Symbiont-mediated Disruption Of Host Cell PML Body Developmental Process Wnt Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Signaling Extracellular Matrix Regulation Of Cell Communication Regulation Of Growth PcG Protein Complex Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Phospholipase Activity Positive Regulation Of MAPK Cascade Cell Communication
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