FGF2 and CRYAB

Number of citations of the paper that reports this interaction (PubMedID 17487982)
0

Data Source:
BioGRID (unspecified method)

		FGF2	CRYAB
Description		fibroblast growth factor 2	crystallin alpha B
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm	Extracellular Region Nucleus Nucleoplasm Cytoplasm Mitochondrion Lysosome Cytosol Plasma Membrane Cell Surface Z Disc Axon M Band I Band Actin Filament Bundle Protein-containing Complex Dendritic Spine Perikaryon Contractile Muscle Fiber Extracellular Exosome Synaptic Membrane Cardiac Myofibril
	Molecular Function	Fibroblast Growth Factor Receptor Binding Cytokine Activity Integrin Binding Protein Binding Growth Factor Activity Heparin Binding Chemokine Binding Chemoattractant Activity Identical Protein Binding Histone H3K9me2/3 Reader Activity Receptor-receptor Interaction	Amyloid-beta Binding Structural Molecule Activity Structural Constituent Of Eye Lens Protein Binding Microtubule Binding Cytoskeletal Protein Binding Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding Metal Ion Binding Unfolded Protein Binding
	Biological Process	Angiogenesis Osteoblast Differentiation Branching Involved In Ureteric Bud Morphogenesis Organ Induction Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Proliferation Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Neuroblast Proliferation Chromatin Organization Transcription By RNA Polymerase II Chemotaxis Signal Transduction Ras Protein Signal Transduction Nervous System Development Neuroblast Proliferation Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Embryo Development Ending In Birth Or Egg Hatching Animal Organ Morphogenesis Glial Cell Differentiation Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Fibroblast Migration Growth Factor Dependent Regulation Of Skeletal Muscle Satellite Cell Proliferation Substantia Nigra Development Cerebellar Granule Cell Precursor Proliferation Positive Regulation Of Cerebellar Granule Cell Precursor Proliferation Neurogenesis Cell Differentiation Hyaluronan Catabolic Process Lung Development Regulation Of Cell Migration Paracrine Signaling Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Wound Healing Inner Ear Auditory Receptor Cell Differentiation Positive Regulation Of Cell Fate Specification Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Blood Vessel Endothelial Cell Migration Endothelial Cell Migration Response To Ethanol Positive Regulation Of Inner Ear Auditory Receptor Cell Differentiation Positive Regulation Of Osteoblast Differentiation Regulation Of Angiogenesis Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Retinal Cell Programmed Cell Death Behavioral Response To Ethanol Embryonic Morphogenesis Positive Regulation Of Smooth Muscle Cell Proliferation Response To Axon Injury Stem Cell Differentiation Stem Cell Development Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Positive Chemotaxis Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Cell Cycle Positive Regulation Of Cell Division Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cardiac Muscle Cell Proliferation Canonical Wnt Signaling Pathway Corticotropin Hormone Secreting Cell Differentiation Thyroid-stimulating Hormone-secreting Cell Differentiation Neuroepithelial Cell Differentiation Chondroblast Differentiation Mammary Gland Epithelial Cell Differentiation Angiogenesis Involved In Coronary Vascular Morphogenesis Negative Regulation Of Wound Healing ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Mechanical Stimulus Stem Cell Proliferation Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Lens Fiber Cell Differentiation Positive Regulation Of MiRNA Transcription Positive Regulation Of Neuroepithelial Cell Differentiation Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Positive Regulation Of Sprouting Angiogenesis Response To Wortmannin Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Lymphatic Endothelial Cell Migration Positive Regulation Of Epithelial Tube Formation Regulation Of Morphogenesis Of An Epithelium Positive Regulation Of Blood Vessel Branching Positive Regulation Of Vascular Endothelial Cell Proliferation Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Positive Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Positive Regulation Of DNA Biosynthetic Process Negative Regulation Of Stem Cell Proliferation Positive Regulation Of Stem Cell Proliferation Positive Regulation Of Stem Cell Differentiation Positive Regulation Of Endothelial Cell Chemotaxis	Response To Hypoxia Lens Development In Camera-type Eye Protein Folding Muscle Contraction Tubulin Complex Assembly Muscle Organ Development Response To Heat Negative Regulation Of Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Cell Growth Microtubule Polymerization Or Depolymerization Negative Regulation Of Protein-containing Complex Assembly Response To Estradiol Negative Regulation Of Intracellular Transport Protein Refolding Response To Hydrogen Peroxide Camera-type Eye Development Negative Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Negative Regulation Of DNA-templated Transcription Protein Stabilization Stress-activated MAPK Cascade Apoptotic Process Involved In Morphogenesis Cellular Response To Gamma Radiation Negative Regulation Of Amyloid Fibril Formation Negative Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		PI3K Cascade PIP3 activates AKT signaling Signaling by activated point mutants of FGFR1 Signaling by activated point mutants of FGFR3 FGFR4 ligand binding and activation FGFR1b ligand binding and activation FGFR3c ligand binding and activation FGFR1c ligand binding and activation FGFR2c ligand binding and activation FGFR2b ligand binding and activation Activated point mutants of FGFR2 Constitutive Signaling by Aberrant PI3K in Cancer POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Syndecan interactions Non-integrin membrane-ECM interactions Phospholipase C-mediated cascade: FGFR1 Phospholipase C-mediated cascade; FGFR2 Phospholipase C-mediated cascade; FGFR3 Phospholipase C-mediated cascade; FGFR4 Downstream signaling of activated FGFR1 SHC-mediated cascade:FGFR1 PI-3K cascade:FGFR1 FRS-mediated FGFR1 signaling PI-3K cascade:FGFR2 SHC-mediated cascade:FGFR2 FRS-mediated FGFR2 signaling SHC-mediated cascade:FGFR3 FRS-mediated FGFR3 signaling PI-3K cascade:FGFR3 FRS-mediated FGFR4 signaling SHC-mediated cascade:FGFR4 PI-3K cascade:FGFR4 Negative regulation of FGFR1 signaling Negative regulation of FGFR2 signaling Negative regulation of FGFR3 signaling Negative regulation of FGFR4 signaling Signaling by FGFR2 in disease Signaling by FGFR1 in disease Signaling by FGFR3 in disease FGFRL1 modulation of FGFR1 signaling RAF/MAP kinase cascade Interleukin-4 and Interleukin-13 signaling PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Signaling by FGFR2 IIIa TM Formation of intermediate mesoderm Formation of the nephric duct TGFBR3 regulates FGF2 signaling Developmental Lineage of Multipotent Pancreatic Progenitor Cells	HSF1-dependent transactivation
Drugs		Sucralfate Pentosan polysulfate Heparin 1,4-Dideoxy-O2-Sulfo-Glucuronic Acid N,O6-Disulfo-Glucosamine 1,4-Dideoxy-5-Dehydro-O2-Sulfo-Glucuronic Acid ABT-510
Diseases			Myofibrillar myopathies (MFM), including: Desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Myotilinopathy (MFM3); Zaspopathy (MFM4); Filaminopathy (MFM5); Bag3opathy Distal muscular dystrophies, including: Welander distal myopathy (WDM); Tibial muscular dystrophy (TMD); Nonaka distal myopathy with rimmed vacuoles (DMRV); Miyoshi myopathy (MM); Laing myopathy (MPD1); Distal nebulin myopathy (DNM); Distal desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Distal myotilinopathy (MFM3); Distal zaspopathy (MFM4); Distal myopathy 3 (MPD2, VCPDM)
GWAS		A body shape index ( 34021172) Acne (severe) ( 30542056) Body mass index ( 25673413) Irritable bowel syndrome ( 24797007) Mosquito bite size ( 28199695) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for body mass index ( 25673412)	Birth weight ( 31043758) Hip circumference adjusted for BMI ( 34021172) PR interval ( 32439900)
Interacting Genes		33 interacting genes: API5 BBS9 CASP1 CD44 CEP57 CRYAB CSNK2A1 CSNK2A2 CSNK2B CXCL13 FGFBP1 FGFR1 FGFR3 FGFR4 FGFRL1 FURIN GPC3 GPC4 HSPG2 IL2 NRP1 PF4 PRMT1 PTX3 RPL6 RPS19 RPS6KA3 SDC1 SDC2 SDC3 SNTG1 THBS1 VTN	58 interacting genes: - ACOT7 APOC2 APP ATM AVP B2M BAG3 BCL2L1 BMPR2 CAPN3 CASP3 CCL22 CCND1 CRYAA CRYBA1 CRYBB2 CRYGC CRYGD CRYGS CS DDX20 DES EPB41 FCGR2A FGF2 GFAP GORASP2 HBA1 HSPB1 HSPB2 HSPB6 HSPB8 INS KRTAP19-5 KRTAP6-1 KRTAP8-1 LALBA LBH MDH2 MIP MRPL11 NGF PRKAG3 PRNP PSMA3 RBM11 SCN5A SLC13A1 SNCA SOD1 SQSTM1 TIAM1 TNPO2 TRAPPC6A TTN UBE2D1 VEGFA
Entrez ID		2247	1410
HPRD ID		00622	00428
Ensembl ID		ENSG00000138685	ENSG00000109846
Uniprot IDs		D9ZGF5 P09038	A0A024R3B9 P02511 V9HW27
PDB IDs		1BAS 1BFB 1BFC 1BFF 1BFG 1BLA 1BLD 1CVS 1EV2 1FGA 1FQ9 1II4 1IIL 2BFH 2FGF 2M49 4FGF 4OEE 4OEF 4OEG 5X1O 6L4O 8HU7 8HUE 8OM6	2KLR 2N0K 2WJ7 2Y1Y 2Y1Z 2Y22 2YGD 3J07 3L1G 3SGM 3SGN 3SGO 3SGP 3SGR 3SGS 4M5S 4M5T 5VVV 6BP9 7ROJ 9BEE
Enriched GO Terms of Interacting Partners?		Fibroblast Growth Factor Binding Cell Surface Receptor Signaling Pathway Heparin Binding Golgi Lumen Fibroblast Growth Factor Receptor Activity Cell Migration Signal Transduction Fibroblast Growth Factor Receptor Signaling Pathway Cell Motility Extracellular Region Protein Kinase CK2 Complex Cell Surface Lysosomal Lumen Regulation Of Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Identical Protein Binding Negative Regulation Of Proteolysis Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Cellular Component Organization Regulation Of Cell Population Proliferation Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Regulation Of Endothelial Cell Migration Regulation Of Signal Transduction Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Cellular Response To Growth Factor Stimulus Collagen V Binding Positive Regulation Of Signal Transduction Negative Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Cell Population Proliferation Regulation Of Proteolysis Positive Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Apoptotic Signaling Pathway Regulation Of Endothelial Cell Proliferation Symbiont-mediated Disruption Of Host Cell PML Body Developmental Process Wnt Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Signaling Extracellular Matrix Regulation Of Cell Communication Regulation Of Growth PcG Protein Complex Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Phospholipase Activity Positive Regulation Of MAPK Cascade Cell Communication	Structural Constituent Of Eye Lens Lens Development In Camera-type Eye Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Response To Stress Negative Regulation Of Programmed Cell Death Regulation Of Neuron Apoptotic Process Negative Regulation Of Apoptotic Process Identical Protein Binding System Process Protein Refolding Regulation Of Transport Response To Metal Ion Regulation Of Autophagy Response To Heat Sensory Perception Regulation Of Multicellular Organismal Process Nervous System Process Apoptotic Process Programmed Cell Death Cellular Response To Metal Ion Positive Regulation Of Growth Cell Death Response To Oxidative Stress Visual Perception Sensory Perception Of Light Stimulus Regulation Of Growth Response To Copper Ion Regulation Of Cell Population Proliferation Positive Regulation Of Multicellular Organismal Process Z Disc Neuron Projection Maintenance Regulation Of Dendritic Spine Maintenance Cellular Response To Stress Response To Unfolded Protein Positive Regulation Of Apoptotic Process Response To Temperature Stimulus Positive Regulation Of Endothelial Cell Chemotaxis Regulation Of Long-term Synaptic Potentiation Regulation Of Protein Localization To Cell Periphery Positive Regulation Of Programmed Cell Death Positive Regulation Of Small Molecule Metabolic Process Positive Regulation Of Endocytosis Cytosol Positive Regulation Of Transport Positive Regulation Of Protein Localization Response To Reactive Oxygen Species Positive Regulation Of Cell Growth Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Ovarian Follicle Development
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