VPS4A and RND2

Number of citations of the paper that reports this interaction (PubMedID 11931639)
21

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		VPS4A	RND2
Description		vacuolar protein sorting 4 homolog A	Rho family GTPase 2
Image			No pdb structure
GO Annotations	Cellular Component	Spindle Pole Nucleus Nuclear Pore Cytoplasm Lysosome Endosome Early Endosome Late Endosome Vacuolar Membrane Centrosome Spindle Cytosol Cytoskeleton Plasma Membrane Endosome Membrane Membrane Midbody Late Endosome Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome Flemming Body ATPase Complex	Acrosomal Membrane Cytosol Plasma Membrane Membrane Cytoplasmic Vesicle
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Protein-containing Complex Binding ATP-dependent Protein Disaggregase Activity	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Protein Kinase Binding
	Biological Process	Actomyosin Contractile Ring Contraction Plasma Membrane Repair Protein Targeting To Lysosome Vesicle Budding From Membrane Autophagy Nucleus Organization Nuclear Envelope Organization Endosome Organization Vacuole Organization Lysosomal Transport Mitotic Metaphase Chromosome Alignment Mitotic Nuclear Membrane Reassembly Regulation Of G2/M Transition Of Mitotic Cell Cycle Protein Transport Vesicle-mediated Transport Endosomal Transport Macroautophagy Viral Release From Host Cell Nuclear Membrane Reassembly Intracellular Cholesterol Transport Negative Regulation Of Cytokinesis Regulation Of Protein Localization Endosomal Vesicle Fusion Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Mitotic Cytokinesis Checkpoint Signaling Viral Budding From Plasma Membrane Protein Depolymerization Cell Division Cytoskeleton-dependent Cytokinesis Late Endosomal Microautophagy Late Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Midbody Abscission Multivesicular Body Sorting Pathway Vesicle Uncoating Membrane Fission Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Autophagosome Maturation Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Exosomal Secretion Positive Regulation Of Viral Budding Via Host ESCRT Complex ESCRT Complex Disassembly ESCRT III Complex Disassembly	Actin Filament Organization Signal Transduction Small GTPase-mediated Signal Transduction Regulation Of Actin Cytoskeleton Organization Collateral Sprouting Positive Regulation Of Collateral Sprouting
Pathways		Budding and maturation of HIV virion Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Sealing of the nuclear envelope (NE) by ESCRT-III	RND2 GTPase cycle
Drugs
Diseases
GWAS		Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545) HDL cholesterol ( 30275531) Logical memory (delayed recall) in normal cognition ( 29274321) Total cholesterol levels in HDL ( 29084231)	Coronary artery disease ( 29212778)
Interacting Genes		14 interacting genes: CFTR CHMP1A CHMP1B CHMP2A CHMP4A CHMP4B CHMP4C CLIC3 NPC1 OGT PLA2G15 RND2 SNCA VPS4B	6 interacting genes: FNBP1 MEOX2 RACGAP1 TUBG1 UBXN11 VPS4A
Entrez ID		27183	8153
HPRD ID		11676	03332
Ensembl ID		ENSG00000132612	ENSG00000108830
Uniprot IDs		Q9UN37	P52198
PDB IDs		1YXR 2JQ9 2K3W
Enriched GO Terms of Interacting Partners?		Viral Budding From Plasma Membrane Late Endosome To Lysosome Transport Viral Budding Via Host ESCRT Complex Regulation Of Mitotic Spindle Assembly Midbody Abscission Viral Budding Nuclear Membrane Reassembly Mitotic Cytokinetic Process ESCRT III Complex Amphisome Membrane Vesicle Fusion With Vacuole Viral Release From Host Cell Plasma Membrane Repair Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Multivesicular Body-lysosome Fusion Multivesicular Body Assembly Multivesicular Body Organization Regulation Of Spindle Assembly Lysosomal Membrane Organization Late Endosome To Vacuole Transport Cytokinetic Process Endosome Transport Via Multivesicular Body Sorting Pathway Regulation Of Mitotic Spindle Organization Membrane Fission Mitotic Metaphase Chromosome Alignment Multivesicular Body Sorting Pathway Kinetochore Microtubule Nuclear Membrane Organization Autophagosome Maturation Metaphase Chromosome Alignment Membrane Assembly Lysosomal Transport Multivesicular Body Membrane Chromosome Localization Biological Process Involved In Interaction With Host Endosome Organization Regulation Of Microtubule Cytoskeleton Organization Nuclear Pore Vacuolar Transport Autophagy Nucleus Organization Multivesicular Body Regulation Of Centrosome Duplication Autophagosome Membrane Plasma Membrane Organization Regulation Of Centrosome Cycle Regulation Of Microtubule-based Process Protein-containing Complex Disassembly Viral Process Organelle Localization	Spindle Cytoskeleton Flemming Body Cytokinetic Process Microtubule Nucleator Activity Actomyosin Contractile Ring Contraction Late Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Late Endosomal Microautophagy Cytoskeleton-dependent Cytokinesis Regulation Of Cytokinesis Contractile Ring Contraction Positive Regulation Of Viral Budding Via Host ESCRT Complex Centralspindlin Complex Somite Specification Polar Microtubule Mitotic Cytokinesis Checkpoint Signaling Regulation Of Cell Division Midbody Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Actomyosin Contractile Ring Assembly ATP-dependent Protein Disaggregase Activity Vesicle Uncoating Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Negative Regulation Of Cytokinesis Mitotic Nuclear Membrane Reassembly ESCRT III Complex Disassembly ESCRT Complex Disassembly Mitotic Spindle Midzone Assembly Gamma-tubulin Ring Complex Gamma-tubulin Complex ATPase Complex Sulfate Transmembrane Transport Spindle Midzone Assembly Cytoplasm Segment Specification Somite Development Microtubule Mitotic Spindle Microtubule Lipid Binding Endosomal Vesicle Fusion Viral Budding From Plasma Membrane Negative Regulation Of Cell Division Vacuolar Membrane Positive Regulation Of Exosomal Secretion Late Endosome To Lysosome Transport Regulation Of Exosomal Secretion Meiotic Spindle Organization Pericentriolar Material Intracellular Cholesterol Transport Viral Budding Via Host ESCRT Complex
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