VPS4A and NPC1

Number of citations of the paper that reports this interaction (PubMedID 16757520)
0

Data Source:
BioGRID (pull down)

		VPS4A	NPC1
Description		vacuolar protein sorting 4 homolog A	NPC intracellular cholesterol transporter 1
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GO Annotations	Cellular Component	Spindle Pole Nucleus Nuclear Pore Cytoplasm Lysosome Endosome Early Endosome Late Endosome Vacuolar Membrane Centrosome Spindle Cytosol Cytoskeleton Plasma Membrane Endosome Membrane Membrane Midbody Late Endosome Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome Flemming Body ATPase Complex	Extracellular Region Nuclear Envelope Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Membrane Late Endosome Membrane Vesicle Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Protein-containing Complex Binding ATP-dependent Protein Disaggregase Activity	Virus Receptor Activity Transmembrane Signaling Receptor Activity Lipid Transporter Activity Protein Binding Cholesterol Binding Signaling Receptor Activity Cholesterol Transfer Activity
	Biological Process	Actomyosin Contractile Ring Contraction Plasma Membrane Repair Protein Targeting To Lysosome Vesicle Budding From Membrane Autophagy Nucleus Organization Nuclear Envelope Organization Endosome Organization Vacuole Organization Lysosomal Transport Mitotic Metaphase Chromosome Alignment Mitotic Nuclear Membrane Reassembly Regulation Of G2/M Transition Of Mitotic Cell Cycle Protein Transport Vesicle-mediated Transport Endosomal Transport Macroautophagy Viral Release From Host Cell Nuclear Membrane Reassembly Intracellular Cholesterol Transport Negative Regulation Of Cytokinesis Regulation Of Protein Localization Endosomal Vesicle Fusion Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Mitotic Cytokinesis Checkpoint Signaling Viral Budding From Plasma Membrane Protein Depolymerization Cell Division Cytoskeleton-dependent Cytokinesis Late Endosomal Microautophagy Late Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Midbody Abscission Multivesicular Body Sorting Pathway Vesicle Uncoating Membrane Fission Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Autophagosome Maturation Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Exosomal Secretion Positive Regulation Of Viral Budding Via Host ESCRT Complex ESCRT Complex Disassembly ESCRT III Complex Disassembly	Liver Development Protein Glycosylation Lipid Metabolic Process Lipid Transport Endocytosis Autophagy Lysosomal Transport Adult Walking Behavior Steroid Metabolic Process Cholesterol Metabolic Process Bile Acid Metabolic Process Response To Xenobiotic Stimulus Gene Expression Cholesterol Storage Programmed Cell Death Sterol Transport Sterol Metabolic Process Macroautophagy Negative Regulation Of Macroautophagy Neurogenesis Intestinal Cholesterol Absorption Cholesterol Transport Membrane Raft Organization Intracellular Lipid Transport Intracellular Cholesterol Transport Cholesterol Efflux Cholesterol Homeostasis Response To Cadmium Ion Symbiont Entry Into Host Cell Establishment Of Localization In Cell Cellular Response To Steroid Hormone Stimulus Cellular Response To Low-density Lipoprotein Particle Stimulus Establishment Of Protein Localization To Membrane Negative Regulation Of Epithelial Cell Apoptotic Process Negative Regulation Of TORC1 Signaling Cyclodextrin Metabolic Process
Pathways		Budding and maturation of HIV virion Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Sealing of the nuclear envelope (NE) by ESCRT-III	LDL clearance
Drugs
Diseases			Niemann-Pick type C disease (NPC), including: Niemann-Pick disease, type C1; Niemann-Pick disease, type C2
GWAS		Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545) HDL cholesterol ( 30275531) Logical memory (delayed recall) in normal cognition ( 29274321) Total cholesterol levels in HDL ( 29084231)	Adult body size ( 32376654) Apolipoprotein A1 levels ( 32203549) Body mass index ( 29273807) Body size at age 10 ( 32376654) Chronotype ( 30696823) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Coronary artery disease ( 29212778) Granulocyte count ( 27863252) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549) Household income (MTAG) ( 31844048) Mental health study participation (provided email address) ( 31263887) Metabolic syndrome ( 31589552) Monocyte percentage of white cells ( 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Obesity ( 19151714) Poultry consumption ( 32066663) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Triglyceride levels ( 32154731 32203549) Triglycerides ( 30275531) Walking pace ( 33128006) White blood cell count ( 27863252)
Interacting Genes		14 interacting genes: CFTR CHMP1A CHMP1B CHMP2A CHMP4A CHMP4B CHMP4C CLIC3 NPC1 OGT PLA2G15 RND2 SNCA VPS4B	7 interacting genes: BUD31 DYRK1A FURIN GPR35 MC4R MTDH VPS4A
Entrez ID		27183	4864
HPRD ID		11676	09622
Ensembl ID		ENSG00000132612	ENSG00000141458
Uniprot IDs		Q9UN37	O15118
PDB IDs		1YXR 2JQ9 2K3W	3GKH 3GKI 3GKJ 3JD8 5F18 5F1B 5HNS 5JNX 5KWY 5U73 5U74 6UOX 6W5R 6W5S 6W5T 6W5U 6W5V 8EUS 9DZ2
Enriched GO Terms of Interacting Partners?		Viral Budding From Plasma Membrane Late Endosome To Lysosome Transport Viral Budding Via Host ESCRT Complex Regulation Of Mitotic Spindle Assembly Midbody Abscission Viral Budding Nuclear Membrane Reassembly Mitotic Cytokinetic Process ESCRT III Complex Amphisome Membrane Vesicle Fusion With Vacuole Viral Release From Host Cell Plasma Membrane Repair Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Multivesicular Body-lysosome Fusion Multivesicular Body Assembly Multivesicular Body Organization Regulation Of Spindle Assembly Lysosomal Membrane Organization Late Endosome To Vacuole Transport Cytokinetic Process Endosome Transport Via Multivesicular Body Sorting Pathway Regulation Of Mitotic Spindle Organization Membrane Fission Mitotic Metaphase Chromosome Alignment Multivesicular Body Sorting Pathway Kinetochore Microtubule Nuclear Membrane Organization Autophagosome Maturation Metaphase Chromosome Alignment Membrane Assembly Lysosomal Transport Multivesicular Body Membrane Chromosome Localization Biological Process Involved In Interaction With Host Endosome Organization Regulation Of Microtubule Cytoskeleton Organization Nuclear Pore Vacuolar Transport Autophagy Nucleus Organization Multivesicular Body Regulation Of Centrosome Duplication Autophagosome Membrane Plasma Membrane Organization Regulation Of Centrosome Cycle Regulation Of Microtubule-based Process Protein-containing Complex Disassembly Viral Process Organelle Localization	Positive Regulation Of Viral Life Cycle Transcription Coactivator Activity Histone H3T45 Kinase Activity Response To Melanocyte-stimulating Hormone Negative Regulation Of Nerve Growth Factor Production Golgi Apparatus Subcompartment Regulation Of Nerve Growth Factor Production Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Dibasic Protein Processing Positive Regulation Of Viral Process Zymogen Inhibition Nerve Growth Factor Production Negative Regulation Of Neurotrophin Production Actomyosin Contractile Ring Contraction Late Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Late Endosomal Microautophagy Contractile Ring Contraction Regulation Of Viral Life Cycle Melanocyte-stimulating Hormone Receptor Activity Negative Regulation Of Receptor Catabolic Process Positive Regulation Of Viral Budding Via Host ESCRT Complex Regulation Of Viral Process Viral Translation Viral Life Cycle Viral Process Mitotic Cytokinesis Checkpoint Signaling Centrosome Negative Regulation Of Heterochromatin Formation Melanocortin Receptor Activity Cytokine Precursor Processing Biological Process Involved In Interaction With Host Nerve Growth Factor Binding Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of Neurofibrillary Tangle Assembly Splicing Factor Binding Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Negative Regulation Of Transforming Growth Factor Beta1 Production ATP-dependent Protein Disaggregase Activity Vesicle Uncoating Intercellular Canaliculus Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Negative Regulation Of Cytokinesis C-X-C Chemokine Receptor Activity Negative Regulation Of Voltage-gated Calcium Channel Activity Regulation Of Eating Behavior Heparan Sulfate Binding Regulation Of Heterochromatin Formation Signal Peptide Processing RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Mitotic Nuclear Membrane Reassembly
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