HSPB7 and PRDM14

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		HSPB7	PRDM14
Description		heat shock protein family B (small) member 7	PR/SET domain 14
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cajal Body Actin Cytoskeleton Aggresome	Nucleus Nucleoplasm
	Molecular Function	Protein Binding Filamin Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA Binding RNA Binding Protein Binding Methyltransferase Activity Zinc Ion Binding Transferase Activity Chromatin DNA Binding Metal Ion Binding Methyltransferase Regulator Activity Histone Methyltransferase Binding
	Biological Process	Response To Unfolded Protein Heart Development Regulation Of Heart Contraction	Negative Regulation Of Transcription By RNA Polymerase II Cell Morphogenesis Cell Fate Specification Inner Cell Mass Cell Fate Commitment Regulation Of Transcription By RNA Polymerase II Germ Cell Development Embryo Implantation Fibroblast Growth Factor Receptor Signaling Pathway Fertilization Regulation Of Gene Expression Stem Cell Population Maintenance Germ-line Stem Cell Population Maintenance Methylation Epigenetic Regulation Of Gene Expression Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Gene Expression, Epigenetic Homeostasis Of Number Of Cells Within A Tissue Positive Regulation Of Flagellated Sperm Motility Positive Regulation Of Stem Cell Population Maintenance
Pathways			Transcriptional regulation of pluripotent stem cells
Drugs
Diseases
GWAS		Arterial stiffness index ( 31235810) Breast cancer, ovarian cancer or prostate cancer (pleiotropy) ( 27432226) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Erectile dysfunction ( 30583798) Hypertrophic cardiomyopathy ( 33495596 33495597) Hypertrophic cardiomyopathy (MTAG) ( 33495596) Hypertrophic cardiomyopathy (sarcomere negative) ( 33495597) Hypertrophic cardiomyopathy (sarcomere positive) ( 33495597) Systolic blood pressure ( 28739976)	Schizophrenia ( 30285260) Testicular germ cell tumor ( 23666240 28604728 28604732)
Interacting Genes		19 interacting genes: APP BAG3 C22orf15 CEP76 DDIT4L DYNLT1 GUCD1 HSPB8 PDLIM7 PIP4K2B PLEKHF2 PRDM14 REL RERE SF3B4 SYCE1 TCF4 TEPSIN TRIM23	68 interacting genes: ABI2 AKAP9 AQP1 ATPAF2 BAG4 BAHD1 BCAR3 BEX2 CARD10 CASP8 CDCA7L CHEK2 CREB5 DGCR6 DMRT3 DRC4 EED EIF4E2 ENKD1 ERBB2 EZH2 FAM83A GEM GLYCTK GPATCH2L HEXIM2 HOXB5 HOXC8 HSP90AA2P HSPA5 HSPB7 ID3 IDH1 KANK2 LNX1 MIA3 MRPL32 MYPOP NDUFB9 PALB2 PATZ1 PAX2 PLEKHF2 PRKAB2 PRPF31 PSMA1 PTPRJ RAD51D RBM10 RCOR3 RUSC1 SAXO4 SCNM1 SNRPC SUZ12 TCAF1 TEAD4 TEKT4 TLE5 TRIM41 TSGA10 TTC32 TXK USP2 WDR25 ZNF250 ZNF587 ZNF835
Entrez ID		27129	63978
HPRD ID		13684	11457
Ensembl ID		ENSG00000173641	ENSG00000147596
Uniprot IDs		D3YTC6 Q68DG0 Q8N241 Q9UBY9	Q9GZV8
PDB IDs		8PA0 8RHA
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Aggrephagy Positive Regulation Of Autophagy Positive Regulation Of Macroautophagy Cellular Response To Unfolded Protein Positive Regulation Of Catabolic Process	Chromatin Silencing Complex Protein Binding Nucleus Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Ubiquitin Protein Ligase Binding Oligodendrocyte Differentiation ESC/E(Z) Complex Facultative Heterochromatin Formation Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Glial Cell Differentiation Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Identical Protein Binding Regulation Of Primary Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Anoikis Pronucleus Sex Chromatin Negative Regulation Of Transcription By RNA Polymerase II
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