FOXP1 and RGL1

Number of citations of the paper that reports this interaction (PubMedID 31623628)
49

Data Source:
BioGRID (unspecified method)

		FOXP1	RGL1
Description		forkhead box P1	ral guanine nucleotide dissociation stimulator like 1
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Cytosol Plasma Membrane
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Core Promoter Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Identical Protein Binding Sequence-specific DNA Binding Metal Ion Binding Nuclear Androgen Receptor Binding Sequence-specific Double-stranded DNA Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of B Cell Apoptotic Process Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II DNA Damage Response Regulation Of Gene Expression Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Gene Expression Striatum Development Osteoclast Differentiation Forebrain Development Response To Lipopolysaccharide Regulation Of Interleukin-1 Beta Production Regulation Of Interleukin-12 Production Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-21 Production Response To Testosterone Osteoclast Development Macrophage Activation Monocyte Activation Endothelial Cell Activation Regulation Of Monocyte Differentiation Negative Regulation Of DNA-templated Transcription Animal Organ Development Positive Regulation Of Smooth Muscle Cell Proliferation Regulation Of Inflammatory Response Positive Regulation Of B Cell Receptor Signaling Pathway Negative Regulation Of Androgen Receptor Signaling Pathway Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development T Follicular Helper Cell Differentiation Cellular Response To Tumor Necrosis Factor Regulation Of Defense Response To Bacterium Regulation Of Macrophage Colony-stimulating Factor Production Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Regulation Of Endothelial Tube Morphogenesis Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production	Signal Transduction Small GTPase-mediated Signal Transduction Ras Protein Signal Transduction
Pathways			PPARA activates gene expression RAF/MAP kinase cascade
Drugs
Diseases
GWAS		Adult body size ( 32376654) Adventurousness ( 30643258) Age at first sexual intercourse ( 34211149) Anorexia nervosa ( 31308545) Apolipoprotein A1 levels ( 32203549) Arthritis (juvenile idiopathic) ( 33106285) Asthma ( 32296059) Attention deficit hyperactivity disorder ( 18821565) Autism spectrum disorder or schizophrenia ( 28540026) Automobile speeding propensity ( 30643258) Barrett's esophagus ( 24121790) Barrett's esophagus or Esophageal adenocarcinoma ( 31527586 27527254) Basal cell carcinoma ( 31174203 33549134 27539887) Beef consumption ( 32066663) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Breast cancer ( 29059683) Childhood maltreatment ( 32066696) Chronotype ( 30696823) Cognitive ability (MTAG) ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Cutaneous squamous cell carcinoma ( 32041948) Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined) ( 24121790) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Eosinophil percentage of white cells ( 32888494) Esophageal adenocarcinoma ( 24121790) Familial lung adenocarcinoma ( 29924316) FEV1 ( 30804560) Gastroesophageal reflux disease ( 31527586) General cognitive ability ( 29844566) General risk tolerance (MTAG) ( 30643258) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Haemorrhoidal disease ( 33888516) Hand grip strength ( 29691431) Height ( 28552196) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Household income (MTAG) ( 31844048) Inflammatory bowel disease ( 28067908) Intelligence (MTAG) ( 29326435) Intraocular pressure ( 29617998 24002674 31798171) Intraocular pressure and central corneal thickness (multi-trait analysis) ( 31798171) Keratinocyte cancer (MTAG) ( 31174203) LDL cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Lung function (FVC) ( 30804560) Lymphocyte count ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Multiple sclerosis ( 31604244 24076602) Nasal polyps ( 30643255) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 27863252 32888494) Non-melanoma skin cancer ( 29739929) Nose size ( 27182965) Number of sexual partners ( 30643258) Oily fish consumption ( 32066663) Optic disc size ( 31809533) Pork consumption ( 32066663) PR interval ( 32439900) Primary sclerosing cholangitis ( 27992413) Prudent dietary pattern ( 28644415) Pulse pressure ( 27841878) Red blood cell count ( 27863252 32888494) Refractive error ( 32231278) Risk-taking tendency (4-domain principal component model) ( 30643258) Schizophrenia ( 30285260) Selective IgA deficiency ( 27723758) Smoking initiation ( 33082346) Squamous cell carcinoma ( 26829030) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Subcutaneous adipose tissue ( 22589738) Systolic blood pressure ( 27841878) Tooth agenesis (maxillary lateral incisors) ( 29364747) Vitiligo ( 27723757) Waist-to-hip ratio adjusted for BMI ( 34021172) Walking pace ( 33128006) White blood cell count ( 32888494)	Antipsychotic drug-induced QTc interval change in schizophrenia ( 29064910) Aspartate aminotransferase levels ( 33547301 33339817 29403010) Attention deficit hyperactivity disorder and conduct disorder ( 18951430) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Hip circumference adjusted for BMI ( 34021172) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Immature fraction of reticulocytes ( 32888494) Peripheral arterial disease (traffic-related air pollution interaction) ( 27082954) Response to antidepressants ( 20360315) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 27863252 32888494) Retinal detachment or retinal break ( 31816047)
Interacting Genes		117 interacting genes: AKR1A1 ALB ALYREF ANLN ANXA2 AURKA BAZ2B C1QBP CCDC167 CCDC73 CDKN2AIP CHSY1 CPSF6 CSDE1 CTBP1 DCD DDX17 DDX19B DLAT DMD DOC2A ECE2 EXOG FOXP2 FOXP4 GAPDH GAR1 GOLGA2 H1-4 H2AC25 HERC1 HNRNPD HNRNPH1 HNRNPK HNRNPUL1 HSPA8 HSPB1 HYDIN IGF2BP3 IKZF1 IL3RA IQSEC2 KIF27 LRRK1 MNAT1 MTUS1 MYH7B NCOR2 NLRC4 NR2F1 NR2F2 PARN PCBP2 PCSK4 PKD1P6 POP7 PTBP1 PURA RAG2 RAN RBMS2 RBMX RGL1 RPL22 RPL23A RPL27 RPL28 RPL31 RPL35 RPL37A RPL4 RPL5 RPL6 RPS15A RPS16 RPS20 RPS27A RPS3 RUVBL1 SATB1 SATB2 SLC22A16 SMARCA2 SNRPA1 SNRPB2 SNRPC SNRPD1 SNRPD2 SNRPE SNRPF SNRPN SOX5 SRP14 SRSF1 SRSF3 SRSF8 SSBP1 STAU1 STAU2 STRAP TARBP2 TBC1D23 THUMPD1 TNFRSF1B TRA2A TUBA1B TUBA8 TYW1B UGGT1 UMPS WBP11 WDR11 WDR72 YY1 ZC3HAV1 ZDHHC16 ZMYM2	5 interacting genes: APP FOXP1 HRAS RIT1 RIT2
Entrez ID		27086	23179
HPRD ID		18518	12032
Ensembl ID		ENSG00000114861	ENSG00000143344
Uniprot IDs		A0A0B4J2F3 A0A3B3IRW5 A0A3B3IST0 A0A3B3IT66 Q548T7 Q8N2P0 Q8TEA2 Q9H334	B7Z2W5 B7Z915 B7ZB61 Q9NZL6
PDB IDs		2KIU	7SCW 7SCX
Enriched GO Terms of Interacting Partners?		RNA Binding Ribonucleoprotein Complex RNA Processing Cytosolic Ribosome RNA Splicing MRNA Metabolic Process MRNA Binding Nucleic Acid Metabolic Process MRNA Processing Cytoplasmic Translation RNA Metabolic Process Nucleobase-containing Compound Metabolic Process MRNA Splicing, Via Spliceosome Macromolecule Metabolic Process RNA Splicing, Via Transesterification Reactions Structural Constituent Of Ribosome Catalytic Step 2 Spliceosome Nucleus Spliceosomal Complex Ribosome Cytosolic Large Ribosomal Subunit U1 SnRNP Nucleic Acid Binding U2 SnRNP Small Nuclear Ribonucleoprotein Complex Translation U4 SnRNP Protein-RNA Complex Assembly U2-type Prespliceosome Assembly Nucleoplasm PICln-Sm Protein Complex U2-type Spliceosomal Complex U2-type Catalytic Step 2 Spliceosome Regulation Of MRNA Splicing, Via Spliceosome SMN-Sm Protein Complex 7-methylguanosine Cap Hypermethylation U5 SnRNP Macromolecule Biosynthetic Process Regulation Of MRNA Processing Regulation Of MRNA Metabolic Process Spliceosomal SnRNP Assembly Negative Regulation Of MRNA Metabolic Process Regulation Of RNA Splicing Spliceosomal Complex Assembly Methylosome U2-type Precatalytic Spliceosome Nucleolus Extracellular Exosome Cytosolic Small Ribosomal Subunit Focal Adhesion	GDP Binding G Protein Activity Ras Protein Signal Transduction Regulation Of Long-term Neuronal Synaptic Plasticity Intracellular Signaling Cassette Small GTPase-mediated Signal Transduction GTPase Activity GTP Binding Regulation Of Neuronal Synaptic Plasticity Myeloid Cell Development Macrophage Activation Glial Cell Development Amyloid-beta Complex Growth Cone Lamellipodium Positive Regulation Of Cytokine Production Regulation Of Chemokine Production Regulation Of Response To Calcium Ion Cell Body Positive Regulation Of MAPK Cascade Regulation Of MiRNA Metabolic Process Amylin Binding Positive Regulation Of JNK Cascade Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Cell Migration Positive Regulation Of Type II Interferon Production Regulation Of Calcium-mediated Signaling Positive Regulation Of Signal Transduction Regulation Of Interleukin-1 Beta Production Positive Regulation Of Cell Motility Acetylcholine Receptor Activator Activity Regulation Of Plasma Membrane Bounded Cell Projection Organization Intracellular Signal Transduction Regulation Of Cell Projection Organization Regulation Of Interleukin-1 Production Positive Regulation Of Cell Communication Regulation Of Type II Interferon Production Positive Regulation Of Signaling Lipoprotein Particle Myeloid Leukocyte Activation Positive Regulation Of Locomotion Positive Regulation Of Protein Import Regulation Of MAPK Cascade GTPase Complex Positive Regulation Of Interleukin-21 Production PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of JNK Cascade Cell Activation Involved In Immune Response Endosome To Plasma Membrane Transport Vesicle
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