AKAP8L and PLEKHN1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		AKAP8L	PLEKHN1
Description		A-kinase anchoring protein 8 like	pleckstrin homology domain containing N1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Nuclear Matrix PML Body Nuclear Speck Ribonucleoprotein Complex	Mitochondrion Cytosol Cytoskeleton Plasma Membrane Membrane Mitochondrial Membrane
	Molecular Function	DNA Binding RNA Binding Protein Binding Lamin Binding Zinc Ion Binding DEAD/H-box RNA Helicase Binding Protein Kinase A Regulatory Subunit Binding Histone Deacetylase Binding Metal Ion Binding	Phosphatidylserine Binding Protein Binding Phosphatidic Acid Binding Cardiolipin Binding Phosphatidylinositol Phosphate Binding
	Biological Process	MRNA Processing Mitotic Chromosome Condensation RNA Splicing Regulation Of MRNA Export From Nucleus Cell Cycle G2/M Phase Transition Positive Regulation Of Transcription By RNA Polymerase II Nuclear Membrane Disassembly	Response To Hypoxia Positive Regulation Of Apoptotic Process 3'-UTR-mediated MRNA Destabilization
Pathways		Formation of WDR5-containing histone-modifying complexes
Drugs
Diseases
GWAS		Red blood cell count ( 32888494)	Height ( 31562340) Parkinson's disease ( 26227905)
Interacting Genes		70 interacting genes: ABI2 ACTN2 AP1M1 ASF1B ATOSB ATPAF2 BEX3 BRME1 CARHSP1 CATSPER1 CCDC120 CCDC24 CDC6 CNNM3 CREB5 CSTF2 CSTF2T DGCR6 DHX9 DMRT3 DSCR9 EMD ENKD1 EPHX3 FOXD4 GPANK1 GPS2 HEMK1 HGS HSF4 HUNK ICAM4 IL18R1 INCA1 KPRP LAGE3 LBR MYOZ1 MYPOP OR7A17 PATZ1 PCDHB14 PEF1 PITX1 PLEKHN1 PRKAA2 PRKACA PRPF40A PTP4A2 RAMAC RASAL3 RTP5 RUSC1 SAMD4A SAXO1 SAXO4 SH3RF2 SNRPC TEKT4 TEKT5 TENT5B TFAP2D TIAL1 TLE5 TMPO TMSB4X TRIB3 TSGA10IP WDR25 ZNF366	43 interacting genes: ABI2 AKAP8L ARID5A ATXN1 CBY2 CYSRT1 FHL5 HOXA1 KRT31 KRT36 KRT83 KRTAP1-3 KRTAP19-6 KRTAP6-2 LPXN LZTS2 MTUS2 NBPF19 NFKBID NOTCH2NLA PDLIM7 PIH1D1 PPM1J PPP1R16B PRICKLE4 PRKAA2 PUSL1 REL RFX6 SAXO4 SORBS3 SSC4D TAX1BP1 TCF4 TP53BP2 TRAF1 TRIM27 TRIP6 USP54 WWOX ZC4H2 ZNF438 ZRANB1
Entrez ID		26993	84069
HPRD ID		10641	13190
Ensembl ID		ENSG00000011243	ENSG00000187583
Uniprot IDs		Q9ULX6	Q494U1
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Binding Sperm Flagellum	Intermediate Filament Structural Constituent Of Skin Epidermis Keratin Filament
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