PABPC1 and CSDE1

Number of citations of the paper that reports this interaction (PubMedID 35831314)
73

Data Source:
BioGRID (biochemical)
HPRD (in vivo)

		PABPC1	CSDE1
Description		poly(A) binding protein cytoplasmic 1	cold shock domain containing E1
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GO Annotations	Cellular Component	Nucleus Spliceosomal Complex Cytoplasm Cytosol Focal Adhesion Cytoplasmic Stress Granule Membrane Lamellipodium Cell Leading Edge Cytoplasmic Ribonucleoprotein Granule Cell Projection Extracellular Exosome Catalytic Step 2 Spliceosome MCRD-mediated MRNA Stability Complex Ribonucleoprotein Complex	P-body Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Cytoplasmic Stress Granule CRD-mediated MRNA Stability Complex MCRD-mediated MRNA Stability Complex
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding Poly(A) Binding Poly(U) RNA Binding Translation Activator Activity	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding RNA Stem-loop Binding LncRNA Binding RISC Complex Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Regulatory NcRNA-mediated Gene Silencing Positive Regulation Of Viral Genome Replication MRNA Stabilization Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening CRD-mediated MRNA Stabilization Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Positive Regulation Of Cytoplasmic Translation	Regulation Of Translational Initiation Male Gonad Development Stress Granule Assembly Positive Regulation Of Translation ERK1 And ERK2 Cascade CRD-mediated MRNA Stabilization Nuclear-transcribed MRNA Catabolic Process, No-go Decay IRES-dependent Viral Translational Initiation Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of Cytoplasmic Translation
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Deadenylation of mRNA Deadenylation of mRNA AUF1 (hnRNP D0) binds and destabilizes mRNA Translation initiation complex formation Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) M-decay: degradation of maternal mRNAs by maternally stored factors Z-decay: degradation of maternal mRNAs by zygotically expressed factors
Drugs
Diseases
GWAS		Body mass index ( 26426971) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean corpuscular hemoglobin ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)	Autism ( 24189344)
Interacting Genes		64 interacting genes: ANAPC5 APBB1 ATP6V1C1 ATXN2 CARM1 CEBPA CHAF1A CNOT6 CNOT7 CSDE1 DCAF13 DUX4 EIF4B EIF4G1 EIF4G3 ERBB2 GSPT1 GSPT2 HBB HNRNPD HNRNPK IL7R ITCH LARP4B LINC01554 LRP12 LRP1B MAPKAPK2 MET MKRN1 NDRG1 ODF1 OGT PAIP1 PAIP2 PAIP2B PAN2 PAN3 PCBP1 PCBP2 PCED1A PCSK7 PIN1 PITPNA PRMT6 PXN RACK1 RBM4 RIMS2 SNCA SREK1 STAU1 SYCP3 SYNCRIP TERT TOB1 TOB2 U2AF1 UNK USP10 USP7 WBP4 WEE2-AS1 YWHAG	31 interacting genes: ARHGAP5 C11orf68 CDC7 CEBPA CTBS DOK1 DPYD ERBB2 FAM9B FOXP1 GCKR GCNT1 GFI1 HID1 HNRNPD IGFBP5 KCNMB4 NEIL3 PABPC1 PCSK7 PSMG1 RNF10 SH3GLB1 SLIT2 SNRPB2 SNW1 STT3A SYNCRIP WBP4 WFS1 WNK1
Entrez ID		26986	7812
HPRD ID		05247	15949
Ensembl ID		ENSG00000070756	ENSG00000009307
Uniprot IDs		P11940	O75534
PDB IDs		1CVJ 1G9L 1JGN 1JH4 2K8G 2RQG 2RQH 2X04 3KTP 3KTR 3KUI 3KUJ 3KUR 3KUS 3KUT 3PKN 3PTH 4F02 4F25 4F26 5DX1 5DX8 5DXA 5LGP 5LGQ 5LGR 5LGS 7BN3 8SMO	1WFQ 1X65 2YTV 2YTX 2YTY
Enriched GO Terms of Interacting Partners?		Post-transcriptional Regulation Of Gene Expression Regulation Of Translation RNA Binding Regulation Of Protein Metabolic Process Regulation Of Translational Initiation Positive Regulation Of Translation Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Catabolic Process Regulation Of MRNA Stability Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of MRNA Metabolic Process Regulation Of RNA Stability Negative Regulation Of Metabolic Process Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay MCRD-mediated MRNA Stability Complex Negative Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Translation MRNA Binding Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Cytosol Nucleic Acid Binding Nucleic Acid Metabolic Process Negative Regulation Of Protein Metabolic Process MRNA Metabolic Process Regulation Of Biological Quality Cytoplasmic Stress Granule CRD-mediated MRNA Stabilization RNA Metabolic Process Poly(A)-specific Ribonuclease Activity Positive Regulation Of Metabolic Process Negative Regulation Of MRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Cytoplasmic Translation Positive Regulation Of Biosynthetic Process MRNA Catabolic Process Negative Regulation Of MRNA Catabolic Process Positive Regulation Of Cytoplasmic Translation RNA Catabolic Process Nuclear-transcribed MRNA Poly(A) Tail Shortening Negative Regulation Of Translational Initiation Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly	MCRD-mediated MRNA Stability Complex CRD-mediated MRNA Stabilization Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of Cytoplasmic Translation Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Spliceosomal Complex Catalytic Step 2 Spliceosome Macromolecule Metabolic Process MRNA Splicing, Via Spliceosome Regulation Of Cytoplasmic Translation RNA Splicing, Via Transesterification Reactions Regulation Of Translation Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Positive Regulation Of Translation MRNA Stabilization Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Carbohydrate Homeostasis Glucose Homeostasis Negative Regulation Of MRNA Catabolic Process RNA Stabilization Nucleic Acid Binding RNA Splicing Proteasome Binding Response To Ketone Post-transcriptional Regulation Of Gene Expression Negative Regulation Of RNA Catabolic Process Negative Regulation Of MRNA Metabolic Process Motor Neuron Axon Guidance Nuclear Androgen Receptor Binding MRNA Processing Regulation Of Protein Metabolic Process Regulation Of Biological Quality Nuclear Matrix Cellular Response To Stress RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Uracil Binding Beta-alanine Metabolic Process Thymidine Catabolic Process Beta-alanine Biosynthetic Process Dihydropyrimidine Dehydrogenase (NADP+) Activity Hepatocyte Dedifferentiation Cellular Response To Putrescine Negative Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Skeletal Muscle Hypertrophy U2-type Catalytic Step 2 Spliceosome Proteasome Core Complex Assembly Induction Of Negative Chemotaxis Corticospinal Neuron Axon Guidance Through Spinal Cord Protein Localization To Vacuolar Membrane MCM Complex Binding
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