CSDE1 and DOK1

		CSDE1	DOK1
Description		cold shock domain containing E1	docking protein 1
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GO Annotations	Cellular Component	P-body Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Cytoplasmic Stress Granule CRD-mediated MRNA Stability Complex MCRD-mediated MRNA Stability Complex	Nucleus Cytoplasm Cytosol Perinuclear Region Of Cytoplasm
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding RNA Stem-loop Binding LncRNA Binding RISC Complex Binding	Protein Binding
	Biological Process	Regulation Of Translational Initiation Male Gonad Development Stress Granule Assembly Positive Regulation Of Translation ERK1 And ERK2 Cascade CRD-mediated MRNA Stabilization Nuclear-transcribed MRNA Catabolic Process, No-go Decay IRES-dependent Viral Translational Initiation Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of Cytoplasmic Translation	Signal Transduction Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Ras Protein Signal Transduction Intracellular Signal Transduction Macrophage Colony-stimulating Factor Signaling Pathway
Pathways			PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 RET signaling
Drugs
Diseases
GWAS		Autism ( 24189344)	Bell's palsy ( 33602968) Height ( 31562340)
Interacting Genes		31 interacting genes: ARHGAP5 C11orf68 CDC7 CEBPA CTBS DOK1 DPYD ERBB2 FAM9B FOXP1 GCKR GCNT1 GFI1 HID1 HNRNPD IGFBP5 KCNMB4 NEIL3 PABPC1 PCSK7 PSMG1 RNF10 SH3GLB1 SLIT2 SNRPB2 SNW1 STT3A SYNCRIP WBP4 WFS1 WNK1	42 interacting genes: ABL1 ABL2 BCR CRK CRKL CSDE1 CSK DOK3 ERBB2 FES FGR FYN GRB10 HCK INPP5D INSR ITGB1 ITGB2 ITGB3 ITGB5 ITGB7 ITK KIT LCK LYN MAP4K4 NCK1 NCK2 PIK3R1 PLCG1 PTK6 PTPN6 PTPRH RASA1 RET SH2D1A SHC1 SRC TEC TLN1 VAV1 YES1
Entrez ID		7812	1796
HPRD ID		15949	04228
Ensembl ID		ENSG00000009307	ENSG00000115325
Uniprot IDs		O75534	B3KP83 B4DJN1 Q14CB2 Q2TA81 Q99704
PDB IDs		1WFQ 1X65 2YTV 2YTX 2YTY	2V76
Enriched GO Terms of Interacting Partners?		MCRD-mediated MRNA Stability Complex CRD-mediated MRNA Stabilization Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of Cytoplasmic Translation Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Spliceosomal Complex Catalytic Step 2 Spliceosome Macromolecule Metabolic Process MRNA Splicing, Via Spliceosome Regulation Of Cytoplasmic Translation RNA Splicing, Via Transesterification Reactions Regulation Of Translation Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Positive Regulation Of Translation MRNA Stabilization Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Carbohydrate Homeostasis Glucose Homeostasis Negative Regulation Of MRNA Catabolic Process RNA Stabilization Nucleic Acid Binding RNA Splicing Proteasome Binding Response To Ketone Post-transcriptional Regulation Of Gene Expression Negative Regulation Of RNA Catabolic Process Negative Regulation Of MRNA Metabolic Process Motor Neuron Axon Guidance Nuclear Androgen Receptor Binding MRNA Processing Regulation Of Protein Metabolic Process Regulation Of Biological Quality Nuclear Matrix Cellular Response To Stress RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Uracil Binding Beta-alanine Metabolic Process Thymidine Catabolic Process Beta-alanine Biosynthetic Process Dihydropyrimidine Dehydrogenase (NADP+) Activity Hepatocyte Dedifferentiation Cellular Response To Putrescine Negative Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Skeletal Muscle Hypertrophy U2-type Catalytic Step 2 Spliceosome Proteasome Core Complex Assembly Induction Of Negative Chemotaxis Corticospinal Neuron Axon Guidance Through Spinal Cord Protein Localization To Vacuolar Membrane MCM Complex Binding	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Protein Tyrosine Kinase Activity Cell Surface Receptor Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Phosphotyrosine Residue Binding Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Immune System Process Cell Migration Regulation Of Cell Adhesion Regulation Of Immune System Process Peptidyl-tyrosine Phosphorylation Fc Receptor Signaling Pathway Cell Motility Positive Regulation Of Cell Adhesion Immune Response-regulating Signaling Pathway Protein Kinase Activity Regulation Of Immune Response Protein Phosphorylation Kinase Activity Immune Response-activating Signaling Pathway Plasma Membrane Leukocyte Migration Integrin-mediated Signaling Pathway Phosphorylation Immune System Process Activation Of Immune Response Fc-gamma Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Immune Response Fc Receptor Mediated Stimulatory Signaling Pathway Antigen Receptor-mediated Signaling Pathway T Cell Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Intracellular Signal Transduction Regulation Of Multicellular Organismal Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Multicellular Organismal Process Negative Regulation Of Immune System Process Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Leukocyte Activation Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction T Cell Costimulation Regulation Of Leukocyte Cell-cell Adhesion Immune Effector Process Regulation Of Signal Transduction
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