GGT1 and KCNMA1

Number of citations of the paper that reports this interaction (PubMedID 15528406)
0

Data Source:
HPRD (in vitro)

		GGT1	KCNMA1
Description		gamma-glutamyltransferase 1	potassium calcium-activated channel subfamily M alpha 1
Image
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Membrane Extracellular Exosome	Plasma Membrane Caveola Voltage-gated Potassium Channel Complex Membrane Apical Plasma Membrane Monoatomic Ion Channel Complex Postsynaptic Membrane
	Molecular Function	Peptidyltransferase Activity Leukotriene-C(4) Hydrolase Protein Binding Peptidase Activity Transferase Activity Acyltransferase Activity Hydrolase Activity Glutathione Hydrolase Activity Leukotriene C4 Gamma-glutamyl Transferase Activity	Actin Binding Monoatomic Ion Channel Activity Voltage-gated Potassium Channel Activity Potassium Channel Activity Protein Binding Calcium-activated Potassium Channel Activity Identical Protein Binding Metal Ion Binding Large Conductance Calcium-activated Potassium Channel Activity
	Biological Process	Regulation Of Immune System Process Proteolysis Amino Acid Metabolic Process Glutamate Metabolic Process Lipid Metabolic Process Fatty Acid Metabolic Process Leukotriene Metabolic Process Glutathione Metabolic Process Glutathione Biosynthetic Process Glutathione Catabolic Process Spermatogenesis Cysteine Biosynthetic Process Peptide Modification Zymogen Activation Regulation Of Inflammatory Response Leukotriene D4 Biosynthetic Process	Response To Hypoxia Monoatomic Ion Transport Potassium Ion Transport Response To Osmotic Stress Intracellular Potassium Ion Homeostasis Monoatomic Ion Transmembrane Transport Response To Carbon Monoxide Vasodilation Regulation Of Membrane Potential Positive Regulation Of Apoptotic Process Negative Regulation Of Cell Volume Response To Calcium Ion Transmembrane Transport Micturition Smooth Muscle Contraction Involved In Micturition Potassium Ion Transmembrane Transport
Pathways		Glutathione synthesis and recycling Synthesis of Leukotrienes (LT) and Eoxins (EX) Aflatoxin activation and detoxification Defective GGT1 causes GLUTH Defective GGT1 in aflatoxin detoxification causes GLUTH LTC4-CYSLTR mediated IL4 production Paracetamol ADME	Ca2+ activated K+ channels cGMP effects Sensory processing of sound by inner hair cells of the cochlea Acetylcholine inhibits contraction of outer hair cells
Drugs		Glutathione	Chlorzoxazone Bendroflumethiazide Procaine Hydroflumethiazide Ritodrine Hydrochlorothiazide Nitrendipine Miconazole Diazoxide Halothane Colforsin Dequalinium Trimebutine
Diseases
GWAS		Acne (severe) ( 24927181) Blood protein levels ( 23696881) Gamma glutamyl transferase levels ( 29403010 32084209 33339817) Gamma glutamyl transpeptidase ( 21909109) Hematological and biochemical traits ( 20139978) Liver enzyme levels ( 18940312) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757 33972514) Protein quantitative trait loci ( 18464913) Serum metabolite levels ( 23093944 33031748) Urinary metabolite levels in chronic kidney disease ( 31959995) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995)	3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Bell's palsy ( 33602968) Blood pressure ( 24954895) Bone mineral density (spine) ( 26911590) Educational attainment ( 25201988) Estimated glomerular filtration rate ( 31015462 31152163) Femur bone mineral density x serum urate levels interaction ( 34046847) Glucocorticoid-induced osteonecrosis ( 26265699) Gut microbiota relative abundance (Faecalibacterium) ( 33208821) Heel bone mineral density ( 28869591 30598549) Hypospadias ( 25108383) Initial pursuit acceleration ( 29064472) Intraocular pressure ( 31959993) Lean body mass ( 28552196) Lumbar spine bone mineral density ( 29499414 22504420) Male-pattern baldness ( 28196072) Mortality in heart failure ( 20400778) Myopia ( 27182965) Obesity ( 21708048) Refractive error ( 32231278) Response to ranibizumab in age-related macular degeneration (exudative) ( 30054556) Schizophrenia ( 33169155) Smoking cessation in chronic obstructive pulmonary disease ( 29631575) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		4 interacting genes: ADORA2A CD53 KCNMA1 NAMPT	7 interacting genes: CACNA1H GGT1 HMOX2 KCNMB1 MAP1A PTK2 SFTPD
Entrez ID		2678	3778
HPRD ID		01980	15967
Ensembl ID		ENSG00000100031	ENSG00000156113
Uniprot IDs		A0A140VJJ9 P19440	A0A087WZL8 A0A1W2PNQ3 A0A1W2PNW6 A0A1W2PP94 A0A1W2PPY5 A0A1W2PQ61 A0A1W2PQA0 A0A1W2PQK5 A0A1W2PQU4 A0A1W2PR56 A0A1W2PR62 A0A1W2PRB0 A0A1W2PRN5 A0A1W2PSD3 B7ZMF5 D5MRH1 Q12791 Q59FH2 Q5SVJ7 Q5SVJ8 Q5SVJ9 S4R453
PDB IDs		4GDX 4GG2 4Z9O 4ZBK 4ZC6 4ZCG 5V4Q	2K44 3MT5 3NAF 6ND0 6V22 6V35 6V38 6V3G 6V5A 7YNZ 7YO0 7YO1 7YO2 7YO3 7YO4 7YO5 8GH9 8GHF 8GHG 8V60 8V63 8V64 8VAV 8VAZ 8Z3S 9CZH 9CZJ 9CZK 9CZM 9CZO 9CZQ 9D18 9D19 9JO3 9JO4
Enriched GO Terms of Interacting Partners?		Blood Vessel Diameter Maintenance Vasodilation Regulation Of Tube Size Identical Protein Binding Renal System Process Large Conductance Calcium-activated Potassium Channel Activity Micturition Nicotinamide Phosphoribosyltransferase Activity Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Acetylcholine Secretion, Neurotransmission Response To Carbon Monoxide Smooth Muscle Contraction Involved In Micturition Regulation Of Acetylcholine Secretion, Neurotransmission Type 5 Metabotropic Glutamate Receptor Binding Nicotinamide Metabolic Process G Protein-coupled Adenosine Receptor Activity Postsynaptic Membrane Negative Regulation Of Cell Volume Positive Regulation Of Circadian Sleep/wake Cycle, Sleep Vascular Process In Circulatory System NADP+ Biosynthetic Process Positive Regulation Of Synaptic Transmission, Cholinergic Regulation Of ERK1 And ERK2 Cascade Circulatory System Process G Protein-coupled Adenosine Receptor Signaling Pathway Urinary Bladder Smooth Muscle Contraction Alkaloid Metabolic Process Inhibitory Postsynaptic Potential Positive Regulation Of Urine Volume Positive Regulation Of Glutamate Secretion Regulation Of Norepinephrine Secretion Calcium-activated Potassium Channel Activity Synaptic Transmission, Dopaminergic Prepulse Inhibition Asymmetric Synapse Axolemma Alpha-actinin Binding Response To Caffeine NAD+ Biosynthetic Process Via The Salvage Pathway Regulation Of Membrane Potential Positive Regulation Of Synaptic Transmission, GABAergic Positive Regulation Of Myoblast Fusion Positive Regulation Of MAPK Cascade Astrocyte Activation Negative Regulation Of Vascular Permeability Intracellular Potassium Ion Homeostasis Positive Regulation Of Neurotransmitter Secretion Positive Regulation Of Circadian Rhythm Regulation Of Urine Volume Regulation Of Glutamate Secretion
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