GGT1

Description		gamma-glutamyltransferase 1
Image
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	Peptidyltransferase Activity Leukotriene-C(4) Hydrolase Protein Binding Peptidase Activity Transferase Activity Acyltransferase Activity Hydrolase Activity Glutathione Hydrolase Activity Leukotriene C4 Gamma-glutamyl Transferase Activity
	Biological Process	Regulation Of Immune System Process Proteolysis Amino Acid Metabolic Process Glutamate Metabolic Process Lipid Metabolic Process Fatty Acid Metabolic Process Leukotriene Metabolic Process Glutathione Metabolic Process Glutathione Biosynthetic Process Glutathione Catabolic Process Spermatogenesis Cysteine Biosynthetic Process Peptide Modification Zymogen Activation Regulation Of Inflammatory Response Leukotriene D4 Biosynthetic Process
Pathways		Glutathione synthesis and recycling Synthesis of Leukotrienes (LT) and Eoxins (EX) Aflatoxin activation and detoxification Defective GGT1 causes GLUTH Defective GGT1 in aflatoxin detoxification causes GLUTH LTC4-CYSLTR mediated IL4 production Paracetamol ADME
Drugs		Glutathione
Diseases
GWAS		Acne (severe) ( 24927181) Blood protein levels ( 23696881) Gamma glutamyl transferase levels ( 29403010 32084209 33339817) Gamma glutamyl transpeptidase ( 21909109) Hematological and biochemical traits ( 20139978) Liver enzyme levels ( 18940312) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757 33972514) Protein quantitative trait loci ( 18464913) Serum metabolite levels ( 23093944 33031748) Urinary metabolite levels in chronic kidney disease ( 31959995) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995)
Novel Interacting Genes		4 novel interacting genes: ADORA2A CD53 KCNMA1 NAMPT
Interacting Genes		4 interacting genes: ADORA2A CD53 KCNMA1 NAMPT
Entrez ID		2678
HPRD ID		01980
Ensembl ID		ENSG00000100031
Uniprot IDs		A0A140VJJ9 P19440
PDB IDs		4GDX 4GG2 4Z9O 4ZBK 4ZC6 4ZCG 5V4Q
Enriched GO Terms of Interacting Partners?		Blood Vessel Diameter Maintenance Vasodilation Regulation Of Tube Size Identical Protein Binding Renal System Process Large Conductance Calcium-activated Potassium Channel Activity Micturition Nicotinamide Phosphoribosyltransferase Activity Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Acetylcholine Secretion, Neurotransmission Response To Carbon Monoxide Smooth Muscle Contraction Involved In Micturition Regulation Of Acetylcholine Secretion, Neurotransmission Type 5 Metabotropic Glutamate Receptor Binding Nicotinamide Metabolic Process G Protein-coupled Adenosine Receptor Activity Postsynaptic Membrane Negative Regulation Of Cell Volume Positive Regulation Of Circadian Sleep/wake Cycle, Sleep Vascular Process In Circulatory System NADP+ Biosynthetic Process Positive Regulation Of Synaptic Transmission, Cholinergic Regulation Of ERK1 And ERK2 Cascade Circulatory System Process G Protein-coupled Adenosine Receptor Signaling Pathway Urinary Bladder Smooth Muscle Contraction Alkaloid Metabolic Process Inhibitory Postsynaptic Potential Positive Regulation Of Urine Volume Positive Regulation Of Glutamate Secretion Regulation Of Norepinephrine Secretion Calcium-activated Potassium Channel Activity Synaptic Transmission, Dopaminergic Prepulse Inhibition Asymmetric Synapse Axolemma Alpha-actinin Binding Response To Caffeine NAD+ Biosynthetic Process Via The Salvage Pathway Regulation Of Membrane Potential Positive Regulation Of Synaptic Transmission, GABAergic Positive Regulation Of Myoblast Fusion Positive Regulation Of MAPK Cascade Astrocyte Activation Negative Regulation Of Vascular Permeability Intracellular Potassium Ion Homeostasis Positive Regulation Of Neurotransmitter Secretion Positive Regulation Of Circadian Rhythm Regulation Of Urine Volume Regulation Of Glutamate Secretion
Tagcloud ?