GGCX and ST3GAL4

		GGCX	ST3GAL4
Description		gamma-glutamyl carboxylase	ST3 beta-galactoside alpha-2,3-sialyltransferase 4
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Membrane	Golgi Membrane Extracellular Region Golgi Apparatus Membrane Golgi Cisterna Membrane
	Molecular Function	Gamma-glutamyl Carboxylase Activity Lyase Activity Vitamin Binding	Beta-galactoside (CMP) Alpha-2,3-sialyltransferase Activity N-acetyllactosaminide Alpha-2,3-sialyltransferase Activity Sialyltransferase Activity Transferase Activity Glycosyltransferase Activity Beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide Alpha-2,3- Sialyltransferase
	Biological Process	Blood Coagulation Protein Modification Process Vitamin K Metabolic Process Negative Regulation Of Neurotransmitter Secretion Protein Maturation Negative Regulation Of Bone Development Negative Regulation Of Testosterone Biosynthetic Process	Protein Glycosylation Lipid Metabolic Process Glycoprotein Biosynthetic Process Glycolipid Biosynthetic Process Oligosaccharide Biosynthetic Process Protein O-linked Glycosylation Via N-acetyl-galactosamine Keratan Sulfate Proteoglycan Biosynthetic Process Viral Protein Processing Positive Regulation Of Blood Coagulation Cognition Sialylation Positive Regulation Of Leukocyte Tethering Or Rolling
Pathways		Gamma-carboxylation of protein precursors Gamma-carboxylation of protein precursors Defective gamma-carboxylation of F9	Pre-NOTCH Processing in Golgi Keratan sulfate biosynthesis Sialic acid metabolism Lewis blood group biosynthesis Maturation of protein 3a Maturation of spike protein Maturation of protein 3a N-Glycan antennae elongation Termination of O-glycan biosynthesis
Drugs		IIa Recombinant Human Coagulation Factor IX (Recombinant) Glutamic acid Menadione Phylloquinone Anisindione Kappadione Coagulation Factor IX Human
Diseases		Pseudoxanthoma elasticum, including: Pseudoxanthoma elasticum (PXE); Pseudoxanthoma elasticum-like disorder with multiple coagulation factor deficiency Combined deficiency of vitamin K-dependent clotting factors (VKCFD)
GWAS		Coronary artery disease ( 26343387 29212778) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) High light scatter reticulocyte count ( 32888494) Myocardial infarction ( 26343387) Prostate cancer ( 21743467) Triglyceride levels ( 32203549)	Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Aspartate aminotransferase levels ( 33547301) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809) Cholesterol, total ( 20686565 24097068 25961943) Coronary artery disease ( 29212778) Factor VIII levels ( 30586737) HDL cholesterol levels ( 32203549) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Height ( 31562340) High light scatter reticulocyte count ( 32888494) LDL cholesterol ( 25961943 24097068 30275531 20686565) LDL cholesterol levels ( 32203549 28334899 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Liver enzyme levels (alkaline phosphatase) ( 33972514 22001757) Low density lipoprotein cholesterol levels ( 33339817 32154731) Mean platelet volume ( 27863252 32888494) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolite levels ( 23823483) Monocyte count ( 32888494) Mumps ( 28928442) N-glycan levels ( 31163085) Platelet count ( 27863252 32888494) Platelet distribution width ( 27863252 32888494) Plateletcrit ( 32888494) Refractive error ( 32231278) Serum alkaline phosphatase levels ( 31666285 33547301 29403010 33339817) Soluble E-selectin levels ( 31217265) Total cholesterol levels ( 33339817 28334899 30275531) vWF levels ( 30586737)
Interacting Genes		14 interacting genes: ARFGAP1 ATP2C1 BGLAP CD8A F10 F2 F7 F9 FXN PDCD5 PPM1G PROC SRPK2 ST3GAL4	3 interacting genes: ARHGDIA CD8B GGCX
Entrez ID		2677	6484
HPRD ID		00665	00084
Ensembl ID		ENSG00000115486	ENSG00000110080
Uniprot IDs		A0A8I5QJA4 P38435	A0A7I2V5F3 A0A7P0RGI5 Q11206 Q6IBE6
PDB IDs		9BUM 9BUR 9BUX 9BVK 9BVL 9BVM 9BVO 9BVP 9BVQ 9BVR
Enriched GO Terms of Interacting Partners?		Golgi Lumen Coagulation Blood Coagulation Hemostasis Serine-type Peptidase Activity Regulation Of Body Fluid Levels Endoplasmic Reticulum Lumen Serine-type Endopeptidase Activity Calcium Ion Binding Regulation Of Blood Coagulation Regulation Of Hemostasis Endopeptidase Activity Positive Regulation Of Blood Coagulation Positive Regulation Of Coagulation Regulation Of Wound Healing Response To Vitamin K Response To Hydroxyisoflavone Regulation Of Response To Wounding Response To Phenylpropanoid Positive Regulation Of Wound Healing Peptidase Activity Extracellular Region Protein Metabolic Process Proteolysis Protein Processing Extracellular Space Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Cytotoxic T Cell Differentiation Negative Regulation Of Coagulation Response To Astaxanthin Hydrolase Activity Response To Estrogen Golgi Cisterna Membrane Negative Regulation Of Bone Development Structural Constituent Of Bone Negative Regulation Of Wound Healing Serine-type Peptidase Complex Response To Thyrotropin-releasing Hormone Golgi Calcium Ion Transport Golgi Calcium Ion Homeostasis P-type Manganese Transporter Activity Trans-Golgi Network Membrane Organization Response To Vitamin Protein Maturation Positive Regulation Of TOR Signaling Response To Carbon Dioxide Response To Thyroid Stimulating Hormone Iron Chaperone Activity Ferroxidase Activity	Rho GDP-dissociation Inhibitor Activity Vitamin Binding Gamma-glutamyl Carboxylase Activity Negative Regulation Of Bone Development Negative Regulation Of Testosterone Biosynthetic Process Regulation Of Testosterone Biosynthetic Process Negative Regulation Of Neurotransmitter Secretion Regulation Of Bone Development Vitamin K Metabolic Process Regulation Of Synaptic Vesicle Cycle MHC Class I Protein Binding T Cell Receptor Complex Regulation Of Ketone Biosynthetic Process Negative Regulation Of Steroid Biosynthetic Process Negative Regulation Of Steroid Metabolic Process
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