GGCX and ATP2C1

		GGCX	ATP2C1
Description		gamma-glutamyl carboxylase	ATPase secretory pathway Ca2+ transporting 1
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GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Membrane	Golgi Membrane Cytoplasm Endoplasmic Reticulum Golgi Apparatus Trans-Golgi Network Plasma Membrane Endomembrane System Membrane Golgi Cisterna Membrane Cis-Golgi Network Membrane
	Molecular Function	Gamma-glutamyl Carboxylase Activity Lyase Activity Vitamin Binding	Nucleotide Binding P-type Calcium Transporter Activity Calcium Ion Binding ATP Binding ATP Hydrolysis Activity Manganese Ion Binding Metal Ion Binding P-type Manganese Transporter Activity
	Biological Process	Blood Coagulation Protein Modification Process Vitamin K Metabolic Process Negative Regulation Of Neurotransmitter Secretion Protein Maturation Negative Regulation Of Bone Development Negative Regulation Of Testosterone Biosynthetic Process	Monoatomic Ion Transport Calcium Ion Transport Manganese Ion Transport Intracellular Calcium Ion Homeostasis Epidermis Development Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Intracellular Manganese Ion Homeostasis Actin Cytoskeleton Organization Golgi Calcium Ion Homeostasis Golgi Calcium Ion Transport Positive Regulation Of Golgi To Plasma Membrane Protein Transport Positive Regulation Of Canonical NF-kappaB Signal Transduction Calcium Ion Transmembrane Transport Manganese Ion Transmembrane Transport Trans-Golgi Network Membrane Organization
Pathways		Gamma-carboxylation of protein precursors Gamma-carboxylation of protein precursors Defective gamma-carboxylation of F9	Ion transport by P-type ATPases
Drugs		IIa Recombinant Human Coagulation Factor IX (Recombinant) Glutamic acid Menadione Phylloquinone Anisindione Kappadione Coagulation Factor IX Human	Enflurane Isoflurane Ritodrine Methoxyflurane Desflurane Sevoflurane Calcium
Diseases		Pseudoxanthoma elasticum, including: Pseudoxanthoma elasticum (PXE); Pseudoxanthoma elasticum-like disorder with multiple coagulation factor deficiency Combined deficiency of vitamin K-dependent clotting factors (VKCFD)	Hailey-Hailey disease; Benign familial pemphigus
GWAS		Coronary artery disease ( 26343387 29212778) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) High light scatter reticulocyte count ( 32888494) Myocardial infarction ( 26343387) Prostate cancer ( 21743467) Triglyceride levels ( 32203549)	Refractive error ( 32231278) Restless legs syndrome ( 29029846) Waist circumference ( 28552196)
Interacting Genes		14 interacting genes: ARFGAP1 ATP2C1 BGLAP CD8A F10 F2 F7 F9 FXN PDCD5 PPM1G PROC SRPK2 ST3GAL4	4 interacting genes: F2RL1 GGCX GPR35 GTF2IRD1
Entrez ID		2677	27032
HPRD ID		00665	05089
Ensembl ID		ENSG00000115486	ENSG00000017260
Uniprot IDs		A0A8I5QJA4 P38435	B4E295 B4E2Q0 P98194
PDB IDs		9BUM 9BUR 9BUX 9BVK 9BVL 9BVM 9BVO 9BVP 9BVQ 9BVR	7YAG 7YAH 7YAI 7YAJ 7YAM 8IWP 8IWR 8IWS 8IWT 8IWU 8IWW
Enriched GO Terms of Interacting Partners?		Golgi Lumen Coagulation Blood Coagulation Hemostasis Serine-type Peptidase Activity Regulation Of Body Fluid Levels Endoplasmic Reticulum Lumen Serine-type Endopeptidase Activity Calcium Ion Binding Regulation Of Blood Coagulation Regulation Of Hemostasis Endopeptidase Activity Positive Regulation Of Blood Coagulation Positive Regulation Of Coagulation Regulation Of Wound Healing Response To Vitamin K Response To Hydroxyisoflavone Regulation Of Response To Wounding Response To Phenylpropanoid Positive Regulation Of Wound Healing Peptidase Activity Extracellular Region Protein Metabolic Process Proteolysis Protein Processing Extracellular Space Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Cytotoxic T Cell Differentiation Negative Regulation Of Coagulation Response To Astaxanthin Hydrolase Activity Response To Estrogen Golgi Cisterna Membrane Negative Regulation Of Bone Development Structural Constituent Of Bone Negative Regulation Of Wound Healing Serine-type Peptidase Complex Response To Thyrotropin-releasing Hormone Golgi Calcium Ion Transport Golgi Calcium Ion Homeostasis P-type Manganese Transporter Activity Trans-Golgi Network Membrane Organization Response To Vitamin Protein Maturation Positive Regulation Of TOR Signaling Response To Carbon Dioxide Response To Thyroid Stimulating Hormone Iron Chaperone Activity Ferroxidase Activity	Coagulation Blood Coagulation Hemostasis Positive Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Negative Regulation Of Transport Positive Regulation Of Renin Secretion Into Blood Stream Gamma-glutamyl Carboxylase Activity Transition Between Slow And Fast Fiber Proteinase-activated Receptor Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Secretion By Cell Positive Regulation Of Eosinophil Degranulation Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Vitamin Binding Negative Regulation Of Bone Development Positive Regulation Of Glomerular Filtration Negative Regulation Of Secretion Regulation Of Renin Secretion Into Blood Stream Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Negative Regulation Of Testosterone Biosynthetic Process Positive Regulation Of Killing Of Cells Of Another Organism Mature Conventional Dendritic Cell Differentiation Thrombin-activated Receptor Activity Positive Regulation Of Toll-like Receptor 3 Signaling Pathway Regulation Of Neutrophil Mediated Cytotoxicity Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Regulation Of Body Fluid Levels Regulation Of Testosterone Biosynthetic Process Negative Regulation Of Neurotransmitter Secretion C-X-C Chemokine Receptor Activity Negative Regulation Of Voltage-gated Calcium Channel Activity Regulation Of Toll-like Receptor 3 Signaling Pathway Thrombin-activated Receptor Signaling Pathway Positive Regulation Of Defense Response To Bacterium Positive Regulation Of Actin Filament Depolymerization Positive Regulation Of Pseudopodium Assembly G Protein-coupled Receptor Activity Positive Regulation Of Phagocytosis, Engulfment Regulation Of Transport Regulation Of Glomerular Filtration Regulation Of Bone Development Vitamin K Metabolic Process Regulation Of Skeletal Muscle Adaptation Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Regulation Of Voltage-gated Calcium Channel Activity Regulation Of Defense Response To Bacterium Pseudopodium Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Positive Regulation Of Protein Depolymerization Renal System Process Involved In Regulation Of Systemic Arterial Blood Pressure
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