GFI1 and CSDE1

		GFI1	CSDE1
Description		growth factor independent 1 transcriptional repressor	cold shock domain containing E1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Matrix Nuclear Body Transcription Repressor Complex	P-body Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Cytoplasmic Stress Granule CRD-mediated MRNA Stability Complex MCRD-mediated MRNA Stability Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Metal Ion Binding Enzyme-substrate Adaptor Activity Sequence-specific Double-stranded DNA Binding	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding RNA Stem-loop Binding LncRNA Binding RISC Complex Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Double-strand Break Repair Via Homologous Recombination Regulation Of Transcription By RNA Polymerase II DNA Damage Response Negative Regulation Of Vitamin D Biosynthetic Process Negative Regulation Of Neuron Projection Development Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Toll-like Receptor Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of Interleukin-6-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Negative Regulation Of Double-strand Break Repair Via Homologous Recombination	Regulation Of Translational Initiation Male Gonad Development Stress Granule Assembly Positive Regulation Of Translation ERK1 And ERK2 Cascade CRD-mediated MRNA Stabilization Nuclear-transcribed MRNA Catabolic Process, No-go Decay IRES-dependent Viral Translational Initiation Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of Cytoplasmic Translation
Pathways		Transcriptional regulation of granulopoiesis
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011) Multiple sclerosis ( 31604244) Multiple sclerosis and type 2 diabetes (pleiotropy) ( 26920376) Systemic lupus erythematosus ( 28714469) Total cholesterol levels ( 33339817)	Autism ( 24189344)
Interacting Genes		8 interacting genes: CSDE1 FBXW7 GSK3B NHERF1 PIAS3 PICK1 RUNX1T1 SPI1	31 interacting genes: ARHGAP5 C11orf68 CDC7 CEBPA CTBS DOK1 DPYD ERBB2 FAM9B FOXP1 GCKR GCNT1 GFI1 HID1 HNRNPD IGFBP5 KCNMB4 NEIL3 PABPC1 PCSK7 PSMG1 RNF10 SH3GLB1 SLIT2 SNRPB2 SNW1 STT3A SYNCRIP WBP4 WFS1 WNK1
Entrez ID		2672	7812
HPRD ID		07527	15949
Ensembl ID		ENSG00000162676	ENSG00000009307
Uniprot IDs		Q99684	O75534
PDB IDs			1WFQ 1X65 2YTV 2YTX 2YTY
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Developmental Process Positive Regulation Of Post-translational Protein Modification Maintenance Of Cell Polarity Negative Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Protein Modification Process Regulation Of Myeloid Cell Differentiation Negative Regulation Of Osteoclast Differentiation Negative Regulation Of Cell Differentiation Negative Regulation Of Macromolecule Metabolic Process Regulation Of Developmental Process Neuron Projection Organization Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Signaling Negative Regulation Of Cell Development Negative Regulation Of Cell Communication Regulation Of Post-translational Protein Modification Negative Regulation Of Myeloid Leukocyte Differentiation Regulation Of Cell Differentiation Positive Regulation Of Protein Metabolic Process Vasculature Development Regulation Of Cell Development SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Neuron Apoptotic Process Regulation Of Protein Localization Regulation Of Microtubule Anchoring At Centrosome Renal Phosphate Ion Absorption Regulation Of Osteoclast Differentiation Negative Regulation Of Catabolic Process Positive Regulation Of Protein Modification Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Apoptotic Signaling Pathway G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Regulation Of Primary Metabolic Process Superior Temporal Gyrus Development Negative Regulation Of Type B Pancreatic Cell Development Establishment Of Cell Polarity Negative Regulation Of Mesenchymal Stem Cell Differentiation Negative Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of Myeloid Dendritic Cell Chemotaxis Pro-T Cell Differentiation Negative Regulation Of Neutrophil Degranulation	MCRD-mediated MRNA Stability Complex CRD-mediated MRNA Stabilization Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of Cytoplasmic Translation Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Spliceosomal Complex Catalytic Step 2 Spliceosome Macromolecule Metabolic Process MRNA Splicing, Via Spliceosome Regulation Of Cytoplasmic Translation RNA Splicing, Via Transesterification Reactions Regulation Of Translation Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Positive Regulation Of Translation MRNA Stabilization Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Carbohydrate Homeostasis Glucose Homeostasis Negative Regulation Of MRNA Catabolic Process RNA Stabilization Nucleic Acid Binding RNA Splicing Proteasome Binding Response To Ketone Post-transcriptional Regulation Of Gene Expression Negative Regulation Of RNA Catabolic Process Negative Regulation Of MRNA Metabolic Process Motor Neuron Axon Guidance Nuclear Androgen Receptor Binding MRNA Processing Regulation Of Protein Metabolic Process Regulation Of Biological Quality Nuclear Matrix Cellular Response To Stress RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Uracil Binding Beta-alanine Metabolic Process Thymidine Catabolic Process Beta-alanine Biosynthetic Process Dihydropyrimidine Dehydrogenase (NADP+) Activity Hepatocyte Dedifferentiation Cellular Response To Putrescine Negative Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Skeletal Muscle Hypertrophy U2-type Catalytic Step 2 Spliceosome Proteasome Core Complex Assembly Induction Of Negative Chemotaxis Corticospinal Neuron Axon Guidance Through Spinal Cord Protein Localization To Vacuolar Membrane MCM Complex Binding
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