MSTN and FSTL3

Number of citations of the paper that reports this interaction (PubMedID 12194980)
0

Data Source:
HPRD (in vitro, in vivo)

		MSTN	FSTL3
Description		myostatin	follistatin like 3
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Extracellular Space Nucleus Nucleoplasm Endoplasmic Reticulum Lumen
	Molecular Function	Signaling Receptor Binding Cytokine Activity Protein Binding Growth Factor Activity Heparin Binding Identical Protein Binding Protein Homodimerization Activity Protein Serine/threonine Kinase Activator Activity	Fibronectin Binding Protein Binding Activin Binding
	Biological Process	Transforming Growth Factor Beta Receptor Signaling Pathway Muscle Organ Development Skeletal Muscle Tissue Development Response To Gravity Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Macrophage Chemotaxis Skeletal Muscle Atrophy Negative Regulation Of Muscle Hypertrophy Skeletal Muscle Satellite Cell Differentiation Myoblast Migration Involved In Skeletal Muscle Regeneration Response To Muscle Activity Ovulation Cycle Process Response To Testosterone Skeletal Muscle Tissue Regeneration Response To Estrogen Response To Ethanol Negative Regulation Of Myoblast Differentiation Positive Regulation Of DNA-templated Transcription Negative Regulation Of Insulin Receptor Signaling Pathway Muscle Cell Cellular Homeostasis Negative Regulation Of Skeletal Muscle Tissue Growth Response To Glucocorticoid Response To Electrical Stimulus Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Trophoblast Cell Migration Cellular Response To Hypoxia Cellular Response To Dexamethasone Stimulus Negative Regulation Of Skeletal Muscle Satellite Cell Proliferation Negative Regulation Of Satellite Cell Differentiation Negative Regulation Of Myoblast Proliferation	Ossification Hematopoietic Progenitor Cell Differentiation Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell-cell Adhesion Cell Differentiation Regulation Of BMP Signaling Pathway Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Activin Receptor Signaling Pathway Negative Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Pathways		FOXO-mediated transcription of cell cycle genes	Antagonism of Activin by Follistatin Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs		Stamulumab
Diseases
GWAS		Daytime sleep phenotypes ( 27126917) Schizophrenia ( 34099189)	Nickel levels ( 26025379)
Interacting Genes		7 interacting genes: ACVR2B APP FSTL3 MFSD6 SGTA TCAP WFIKKN2	5 interacting genes: ADAM12 FN1 INHBA MSTN SMAD4
Entrez ID		2660	10272
HPRD ID		03474	05632
Ensembl ID		ENSG00000138379	ENSG00000070404
Uniprot IDs		O14793 Q53S46	O95633
PDB IDs		5F3B 5F3H 5NTU 5NXS 6UMX	2KCX 3B4V 3SEK
Enriched GO Terms of Interacting Partners?		Activin Binding Regulation Of Activin Receptor Signaling Pathway Roof Of Mouth Development Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Activin Receptor Activity, Type II Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Response To Calcium Ion Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Response To Endoplasmic Reticulum Stress Lipoprotein Particle Peptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization TRC Complex Titin-telethonin Complex Titin Z Domain Binding Muscle Cell Development Skeletal Muscle Myosin Thick Filament Assembly Sarcomerogenesis Anterior/posterior Pattern Specification Venous Blood Vessel Development Activin Receptor Activity Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling BAT3 Complex Binding Myosin Filament Assembly FATZ Binding Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Activin Receptor Signaling Pathway	Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of Follicle-stimulating Hormone Secretion Ameboidal-type Cell Migration Regulation Of Growth Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Growth SMAD Protein Signal Transduction Anatomical Structure Formation Involved In Morphogenesis Response To Muscle Activity Activin Receptor Signaling Pathway Regulation Of ERK1 And ERK2 Cascade Endodermal Cell Differentiation Regulation Of Developmental Process Ovulation Cycle Process Negative Regulation Of Muscle Hypertrophy Response To Hypoxia Response To Decreased Oxygen Levels Positive Regulation Of SMAD Protein Signal Transduction Response To Oxygen Levels Ovarian Follicle Development Negative Regulation Of Multicellular Organismal Process Regulation Of Cell Growth Signaling Receptor Binding Collagen Binding Regulation Of Multicellular Organismal Process Positive Regulation Of Developmental Process Regulation Of SMAD Protein Signal Transduction Regulation Of Multicellular Organismal Development Response To Activity Animal Organ Development Roof Of Mouth Development Activin A Complex Androst-4-ene-3,17-dione Biosynthetic Process Negative Regulation Of Cardiac Myofibril Assembly Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Female Gonad Morphogenesis Regulation Of Cell Differentiation Regulation Of System Process Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Cell Population Proliferation Positive Regulation Of Multicellular Organismal Process Male Gonad Development Extrinsic Apoptotic Signaling Pathway Regulation Of MAPK Cascade Identical Protein Binding Enzyme-linked Receptor Protein Signaling Pathway Negative Regulation Of Cell Differentiation Negative Regulation Of Skeletal Muscle Tissue Growth
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