FSTL3

Description		follistatin like 3
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Nucleoplasm Endoplasmic Reticulum Lumen
	Molecular Function	Fibronectin Binding Protein Binding Activin Binding
	Biological Process	Ossification Hematopoietic Progenitor Cell Differentiation Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell-cell Adhesion Cell Differentiation Regulation Of BMP Signaling Pathway Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Activin Receptor Signaling Pathway Negative Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Pathways		Antagonism of Activin by Follistatin Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs
Diseases
GWAS		Nickel levels ( 26025379)
Novel Interacting Genes		5 novel interacting genes: ADAM12 FN1 INHBA MSTN SMAD4
Interacting Genes		5 interacting genes: ADAM12 FN1 INHBA MSTN SMAD4
Entrez ID		10272
HPRD ID		05632
Ensembl ID		ENSG00000070404
Uniprot IDs		O95633
PDB IDs		2KCX 3B4V 3SEK
Enriched GO Terms of Interacting Partners?		Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of Follicle-stimulating Hormone Secretion Ameboidal-type Cell Migration Regulation Of Growth Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Growth SMAD Protein Signal Transduction Anatomical Structure Formation Involved In Morphogenesis Response To Muscle Activity Activin Receptor Signaling Pathway Regulation Of ERK1 And ERK2 Cascade Endodermal Cell Differentiation Regulation Of Developmental Process Ovulation Cycle Process Negative Regulation Of Muscle Hypertrophy Response To Hypoxia Response To Decreased Oxygen Levels Positive Regulation Of SMAD Protein Signal Transduction Response To Oxygen Levels Ovarian Follicle Development Negative Regulation Of Multicellular Organismal Process Regulation Of Cell Growth Signaling Receptor Binding Collagen Binding Regulation Of Multicellular Organismal Process Positive Regulation Of Developmental Process Regulation Of SMAD Protein Signal Transduction Regulation Of Multicellular Organismal Development Response To Activity Animal Organ Development Roof Of Mouth Development Activin A Complex Androst-4-ene-3,17-dione Biosynthetic Process Negative Regulation Of Cardiac Myofibril Assembly Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Female Gonad Morphogenesis Regulation Of Cell Differentiation Regulation Of System Process Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Cell Population Proliferation Positive Regulation Of Multicellular Organismal Process Male Gonad Development Extrinsic Apoptotic Signaling Pathway Regulation Of MAPK Cascade Identical Protein Binding Enzyme-linked Receptor Protein Signaling Pathway Negative Regulation Of Cell Differentiation Negative Regulation Of Skeletal Muscle Tissue Growth
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