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LATS2 and PDGFRA
Number of citations of the paper that reports this interaction (PubMedID
28205554
)
55
Data Source:
BioGRID
(fluorescent resonance energy transfer)
LATS2
PDGFRA
Description
large tumor suppressor kinase 2
platelet derived growth factor receptor alpha
Image
GO Annotations
Cellular Component
Spindle Pole
Nucleus
Cytoplasm
Centrosome
Cytosol
Cytoskeleton
Centriolar Satellite
Nucleus
Nucleoplasm
Cytoplasm
Endoplasmic Reticulum Membrane
Golgi Apparatus
Cytosol
Plasma Membrane
Microvillus
Cilium
External Side Of Plasma Membrane
Cell Surface
Membrane
Nuclear Body
Cell Junction
Protein-containing Complex
Cell Projection
Receptor Complex
Platelet-derived Growth Factor Receptor-ligand Complex
Molecular Function
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Metal Ion Binding
Protein Serine Kinase Activity
Nucleotide Binding
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Platelet-derived Growth Factor Alpha-receptor Activity
Vascular Endothelial Growth Factor Receptor Activity
Platelet-derived Growth Factor Receptor Binding
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Vascular Endothelial Growth Factor Binding
Protein Homodimerization Activity
Protein-containing Complex Binding
Platelet-derived Growth Factor Binding
Phospholipase C Activator Activity
Biological Process
G1/S Transition Of Mitotic Cell Cycle
Inner Cell Mass Cell Fate Commitment
Inner Cell Mass Cellular Morphogenesis
Protein Phosphorylation
Intracellular Protein Localization
Hormone-mediated Signaling Pathway
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Keratinocyte Differentiation
Hippo Signaling
Positive Regulation Of Hippo Signaling
Intracellular Signal Transduction
Positive Regulation Of Apoptotic Process
Mitotic Cell Cycle Phase Transition
Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Regulation Of Organ Growth
Cell Division
Canonical Wnt Signaling Pathway
Negative Regulation Of Canonical Wnt Signaling Pathway
Negative Regulation Of Protein Localization To Nucleus
Positive Regulation Of NLRP3 Inflammasome Complex Assembly
Luteinization
In Utero Embryonic Development
Cell Activation
Hematopoietic Progenitor Cell Differentiation
Chemotaxis
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Estrogen Metabolic Process
Positive Regulation Of Cell Population Proliferation
Female Gonad Development
Anatomical Structure Morphogenesis
Animal Organ Morphogenesis
Negative Regulation Of Platelet Activation
Cell Migration
Peptidyl-tyrosine Phosphorylation
Signal Transduction Involved In Regulation Of Gene Expression
Extracellular Matrix Organization
Lung Development
Adrenal Gland Development
Positive Regulation Of Cell Migration
Male Genitalia Development
Regulation Of Actin Cytoskeleton Organization
Leydig Cell Differentiation
Cellular Response To Reactive Oxygen Species
Platelet-derived Growth Factor Receptor-alpha Signaling Pathway
Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway
Wound Healing
Odontogenesis Of Dentin-containing Tooth
Protein Autophosphorylation
Platelet-derived Growth Factor Receptor Signaling Pathway
Positive Regulation Of Fibroblast Proliferation
Embryonic Digestive Tract Morphogenesis
Embryonic Cranial Skeleton Morphogenesis
Embryonic Skeletal System Morphogenesis
Skeletal System Morphogenesis
Positive Regulation Of Calcium-mediated Signaling
White Fat Cell Differentiation
Positive Regulation Of Chemotaxis
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Cardiac Myofibril Assembly
Roof Of Mouth Development
Face Morphogenesis
Cell Chemotaxis
Retina Vasculature Development In Camera-type Eye
Positive Regulation Of ERK1 And ERK2 Cascade
Platelet Aggregation
Cellular Response To Amino Acid Stimulus
Metanephric Glomerular Capillary Formation
Regulation Of Mesenchymal Stem Cell Differentiation
Pathways
Signaling by Hippo
PIP3 activates AKT signaling
Downstream signal transduction
Signaling by PDGF
Constitutive Signaling by Aberrant PI3K in Cancer
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants
Signaling by PDGFRA extracellular domain mutants
Imatinib-resistant PDGFR mutants
Sunitinib-resistant PDGFR mutants
Regorafenib-resistant PDGFR mutants
Sorafenib-resistant PDGFR mutants
PDGFR mutants bind TKIs
Drugs
Becaplermin
Imatinib
Sunitinib
XL820
Olaratumab
Pazopanib
Midostaurin
Regorafenib
Ponatinib
Lenvatinib
Nintedanib
Foreskin keratinocyte (neonatal)
Tivozanib
Fostamatinib
Erdafitinib
Amuvatinib
Ripretinib
Diseases
Glioma
GWAS
3-month functional outcome in ischaemic stroke (modified Rankin score) (
30796134
)
Femur bone mineral density x serum urate levels interaction (
34046847
)
Hip circumference adjusted for BMI (
34021172
)
Refractive error (
32231278
)
Adult asthma (
27611488
)
Asthma (
27611488
)
Blood protein levels (
30072576
)
Cadmium levels (
26025379
)
Core binding factor acute myeloid leukemia (
27903959
)
Corneal astigmatism (
29422769
22144915
)
Corneal curvature (
24963161
23401653
21665993
)
Height (
18193045
)
Hematocrit (
29403010
)
Hemoglobin (
29403010
)
Lupus nephritis in systemic lupus erythematosus (
24925725
)
Macular thickness (
30535121
)
Mean corpuscular hemoglobin (
20139978
29403010
)
Mean corpuscular volume (
29403010
20139978
)
Platelet count (
29403010
)
Post bronchodilator FEV1/FVC ratio (
26634245
)
Pulse pressure (
30578418
)
Red blood cell count (
28453575
29403010
20139978
)
Serum VEGFR2 concentration (
25411163
)
Systolic blood pressure (
30578418
)
Uterine fibroids (
30194396
31649266
)
Vertical cup-disc ratio (adjusted for vertical disc diameter) (
31959993
)
Vertical cup-disc ratio (multi-trait analysis) (
31959993
)
Interacting Genes
71 interacting genes:
ABL1
AJUBA
AKT1
ARAF
ARNT
AURKA
AURKB
BECN1
BRAF
CBLC
CCND2
CCNE1
CD44
CDK2
CDK4
CDK6
CDKN1A
CDKN2A
CDKN2B
CDKN2C
CHEK1
CHEK2
CTNNB1
DCAF1
DYRK1A
EPHA2
ERBB2
EZH2
FGFR4
FHL3
FLT1
FZR1
GLIS1
GLIS2
GRAP2
GRM1
HGF
HIF1A
KAT2A
KDELR2
KIF23
MAP2K3
MAP2K5
MAPK14
MDM4
MET
MOB3A
MOB3B
MOB3C
MOB4
MYC
NFIC
PDGFRA
RAF1
RASSF1
RELA
SIAH2
SMAD2
SNAI1
SRC
STK11
STK3
SUZ12
TAFAZZIN
TEAD2
TP53
TSC1
WWTR1
YAP1
YWHAG
YWHAZ
66 interacting genes:
AKT1
ALB
ARNT
AURKA
BECN1
CAV1
CAV3
CBL
CCND2
CD244
CD44
CDK4
CDK6
CDKN2A
CDKN2B
CDKN2C
CRK
CRKL
EGFR
ERBB2
ERBB3
FBXO25
FZR1
GRB14
GRM1
HGF
ITGAV
ITGB3
JAK1
KASH5
KDELR2
LATS2
MAP2K5
MYC
NF2
NHERF1
PDGFA
PDGFB
PDGFC
PDGFRB
PIK3CA
PIK3R1
PLCG1
PLPP6
PRMT5
PTPN11
RAF1
RAPGEF1
SHB
SHF
SMURF1
SNX2
SNX4
SNX6
SPOCK1
SRPK1
STAT1
STAT3
STAT5A
STAT5B
STK11
TERT
TGFBR2
TP53
TTYH2
ULBP2
Entrez ID
26524
5156
HPRD ID
07277
01429
Ensembl ID
ENSG00000150457
ENSG00000134853
Uniprot IDs
Q9NRM7
P16234
PDB IDs
4ZRI
1GQ5
5GRN
5K5X
6A32
6JOI
6JOJ
6JOK
6JOL
7LBF
7RAM
8PQH
8PQI
8PQJ
8PQK
9GZH
Enriched GO Terms of Interacting Partners
?
Regulation Of Intracellular Signal Transduction
Regulation Of Signal Transduction
Kinase Activity
Protein Kinase Activity
Regulation Of Cell Communication
Regulation Of Signaling
Intracellular Signal Transduction
Signal Transduction
Regulation Of Cell Population Proliferation
Animal Organ Development
Negative Regulation Of Signal Transduction
Positive Regulation Of Metabolic Process
Regulation Of Cell Cycle
Response To Growth Factor
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Negative Regulation Of Programmed Cell Death
Regulation Of Cell Cycle Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Metabolic Process
Protein Serine/threonine Kinase Activity
Negative Regulation Of Intracellular Signal Transduction
Positive Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Apoptotic Process
Protein Serine Kinase Activity
Regulation Of Protein Metabolic Process
Negative Regulation Of RNA Metabolic Process
Regulation Of Primary Metabolic Process
Regulation Of Cell Cycle Phase Transition
Nucleus
Regulation Of Programmed Cell Death
Intracellular Signaling Cassette
Positive Regulation Of Signal Transduction
Regulation Of Metabolic Process
Protein Phosphorylation
Protein Modification Process
Regulation Of Protein Modification Process
Regulation Of Signal Transduction By P53 Class Mediator
Negative Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Cell Population Proliferation
Cell Differentiation
Regulation Of Mitotic Cell Cycle
Cellular Response To Stress
Regulation Of Macromolecule Metabolic Process
Transferase Activity
Phosphorylation
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Biosynthetic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Cell Population Proliferation
Enzyme-linked Receptor Protein Signaling Pathway
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Cell Surface Receptor Signaling Pathway
Response To Growth Factor
Cellular Response To Growth Factor Stimulus
Positive Regulation Of Signal Transduction
Signal Transduction
Positive Regulation Of Cell Population Proliferation
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Developmental Process
Regulation Of Intracellular Signal Transduction
Regulation Of Multicellular Organismal Process
Regulation Of Signal Transduction
Regulation Of Epithelial Cell Proliferation
Developmental Process
Cellular Developmental Process
Regulation Of Mitotic Cell Cycle
Regulation Of Signaling
Regulation Of Cell Communication
Regulation Of Cell Cycle
Regulation Of Apoptotic Process
Cell Population Proliferation
Regulation Of Programmed Cell Death
Regulation Of MAPK Cascade
Regulation Of Cellular Component Organization
Negative Regulation Of Apoptotic Process
Regulation Of Cell Differentiation
Negative Regulation Of Programmed Cell Death
Regulation Of Cell Adhesion
Cell Differentiation
Animal Organ Development
Negative Regulation Of Cell Differentiation
Regulation Of Fibroblast Proliferation
Positive Regulation Of Cell Migration
Intracellular Signal Transduction
Intracellular Signaling Cassette
Positive Regulation Of Cell Motility
Positive Regulation Of Locomotion
Regulation Of Growth
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Cellular Response To Epidermal Growth Factor Stimulus
Positive Regulation Of Epithelial Cell Proliferation
Regulation Of Cell Motility
Regulation Of Cell Development
Response To Epidermal Growth Factor
Positive Regulation Of Multicellular Organismal Process
Negative Regulation Of Developmental Process
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Tagcloud (Difference)
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Tagcloud (Intersection)
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