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PDGFRA and KASH5
Number of citations of the paper that reports this interaction (PubMedID
25416956
)
56
Data Source:
BioGRID
(two hybrid)
PDGFRA
KASH5
Description
platelet derived growth factor receptor alpha
KASH domain containing 5
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Endoplasmic Reticulum Membrane
Golgi Apparatus
Cytosol
Plasma Membrane
Microvillus
Cilium
External Side Of Plasma Membrane
Cell Surface
Membrane
Nuclear Body
Cell Junction
Protein-containing Complex
Cell Projection
Receptor Complex
Platelet-derived Growth Factor Receptor-ligand Complex
Chromosome, Telomeric Region
Lateral Element
Nucleus
Nuclear Envelope
Nuclear Outer Membrane
Chromosome
Membrane
Meiotic Nuclear Membrane Microtubule Tethering Complex
Meiotic Spindle Pole
Molecular Function
Nucleotide Binding
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Platelet-derived Growth Factor Alpha-receptor Activity
Vascular Endothelial Growth Factor Receptor Activity
Platelet-derived Growth Factor Receptor Binding
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Vascular Endothelial Growth Factor Binding
Protein Homodimerization Activity
Protein-containing Complex Binding
Platelet-derived Growth Factor Binding
Phospholipase C Activator Activity
Protein Binding
Identical Protein Binding
Dynein Complex Binding
Biological Process
Luteinization
In Utero Embryonic Development
Cell Activation
Hematopoietic Progenitor Cell Differentiation
Chemotaxis
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Estrogen Metabolic Process
Positive Regulation Of Cell Population Proliferation
Female Gonad Development
Anatomical Structure Morphogenesis
Animal Organ Morphogenesis
Negative Regulation Of Platelet Activation
Cell Migration
Peptidyl-tyrosine Phosphorylation
Signal Transduction Involved In Regulation Of Gene Expression
Extracellular Matrix Organization
Lung Development
Adrenal Gland Development
Positive Regulation Of Cell Migration
Male Genitalia Development
Regulation Of Actin Cytoskeleton Organization
Leydig Cell Differentiation
Cellular Response To Reactive Oxygen Species
Platelet-derived Growth Factor Receptor-alpha Signaling Pathway
Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway
Wound Healing
Odontogenesis Of Dentin-containing Tooth
Protein Autophosphorylation
Platelet-derived Growth Factor Receptor Signaling Pathway
Positive Regulation Of Fibroblast Proliferation
Embryonic Digestive Tract Morphogenesis
Embryonic Cranial Skeleton Morphogenesis
Embryonic Skeletal System Morphogenesis
Skeletal System Morphogenesis
Positive Regulation Of Calcium-mediated Signaling
White Fat Cell Differentiation
Positive Regulation Of Chemotaxis
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Cardiac Myofibril Assembly
Roof Of Mouth Development
Face Morphogenesis
Cell Chemotaxis
Retina Vasculature Development In Camera-type Eye
Positive Regulation Of ERK1 And ERK2 Cascade
Platelet Aggregation
Cellular Response To Amino Acid Stimulus
Metanephric Glomerular Capillary Formation
Regulation Of Mesenchymal Stem Cell Differentiation
Double-strand Break Repair Via Homologous Recombination
Actin Filament Organization
Homologous Chromosome Pairing At Meiosis
Spermatogenesis
Telomere Localization
Meiotic Telomere Clustering
Oogenesis
Spindle Assembly
Meiotic Cell Cycle
Spindle Localization
Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation
Pathways
PIP3 activates AKT signaling
Downstream signal transduction
Signaling by PDGF
Constitutive Signaling by Aberrant PI3K in Cancer
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants
Signaling by PDGFRA extracellular domain mutants
Imatinib-resistant PDGFR mutants
Sunitinib-resistant PDGFR mutants
Regorafenib-resistant PDGFR mutants
Sorafenib-resistant PDGFR mutants
PDGFR mutants bind TKIs
Drugs
Becaplermin
Imatinib
Sunitinib
XL820
Olaratumab
Pazopanib
Midostaurin
Regorafenib
Ponatinib
Lenvatinib
Nintedanib
Foreskin keratinocyte (neonatal)
Tivozanib
Fostamatinib
Erdafitinib
Amuvatinib
Ripretinib
Diseases
Glioma
GWAS
Adult asthma (
27611488
)
Asthma (
27611488
)
Blood protein levels (
30072576
)
Cadmium levels (
26025379
)
Core binding factor acute myeloid leukemia (
27903959
)
Corneal astigmatism (
29422769
22144915
)
Corneal curvature (
24963161
23401653
21665993
)
Height (
18193045
)
Hematocrit (
29403010
)
Hemoglobin (
29403010
)
Lupus nephritis in systemic lupus erythematosus (
24925725
)
Macular thickness (
30535121
)
Mean corpuscular hemoglobin (
20139978
29403010
)
Mean corpuscular volume (
29403010
20139978
)
Platelet count (
29403010
)
Post bronchodilator FEV1/FVC ratio (
26634245
)
Pulse pressure (
30578418
)
Red blood cell count (
28453575
29403010
20139978
)
Serum VEGFR2 concentration (
25411163
)
Systolic blood pressure (
30578418
)
Uterine fibroids (
30194396
31649266
)
Vertical cup-disc ratio (adjusted for vertical disc diameter) (
31959993
)
Vertical cup-disc ratio (multi-trait analysis) (
31959993
)
Interacting Genes
66 interacting genes:
AKT1
ALB
ARNT
AURKA
BECN1
CAV1
CAV3
CBL
CCND2
CD244
CD44
CDK4
CDK6
CDKN2A
CDKN2B
CDKN2C
CRK
CRKL
EGFR
ERBB2
ERBB3
FBXO25
FZR1
GRB14
GRM1
HGF
ITGAV
ITGB3
JAK1
KASH5
KDELR2
LATS2
MAP2K5
MYC
NF2
NHERF1
PDGFA
PDGFB
PDGFC
PDGFRB
PIK3CA
PIK3R1
PLCG1
PLPP6
PRMT5
PTPN11
RAF1
RAPGEF1
SHB
SHF
SMURF1
SNX2
SNX4
SNX6
SPOCK1
SRPK1
STAT1
STAT3
STAT5A
STAT5B
STK11
TERT
TGFBR2
TP53
TTYH2
ULBP2
112 interacting genes:
ABHD1
ADIPOQ
ANKRD46
ATF7
BAG5
BCL2L2
BET1
C14orf180
CCDC120
CCDC87
CDC73
CDKL3
CIB3
CLDN8
CMTM5
CRABP2
CTXN3
CWF19L2
CXCL16
CXCL9
CYBC1
DERL1
DNAJC30
EFNA5
EMD
FAM161A
FAM241B
FAM50B
FAM90A1
FATE1
FIS1
FRA10AC1
FTCD
FXYD3
GABARAPL2
GALNT2
GIMAP5
GOSR2
GPATCH4
GPR25
HMOX1
ITGAM
ITM2B
JAGN1
KDM1A
LARP1
LAT
LENG1
LHFPL5
LMNA
LRCH4
MALL
MARCHF2
MMP14
MOSPD3
MS4A1
MTX2
NRIP3
NSG1
NTAQ1
OLFM4
PDGFRA
PGAP2
PGRMC1
PIGU
PLP2
PLPP6
PPP1R18
RIPPLY2
RNF146
RSPH14
RSRC2
RTP2
SENP2
SERP2
SGTA
SHMT2
SLC30A2
SLC35B4
SLC41A1
SLC41A2
SLC5A4
SLC61A1
SLN
SMCO4
SNAP47
STBD1
STX12
STX5
TCF25
TMEM11
TMEM147
TMEM14C
TMEM19
TMEM41A
TMEM86A
TMPRSS4
TNF
TRAF3IP3
TRARG1
TSHZ3
TTC23
UPK1B
UPK2
VAMP1
VAMP2
VAMP4
VMA12
VTI1B
ZC2HC1C
ZFPL1
ZNF250
Entrez ID
5156
147872
HPRD ID
01429
08134
Ensembl ID
ENSG00000134853
ENSG00000161609
Uniprot IDs
P16234
Q8N6L0
PDB IDs
1GQ5
5GRN
5K5X
6A32
6JOI
6JOJ
6JOK
6JOL
7LBF
7RAM
8PQH
8PQI
8PQJ
8PQK
9GZH
6R2I
6WMF
Enriched GO Terms of Interacting Partners
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Regulation Of Cell Population Proliferation
Enzyme-linked Receptor Protein Signaling Pathway
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Cell Surface Receptor Signaling Pathway
Response To Growth Factor
Cellular Response To Growth Factor Stimulus
Positive Regulation Of Signal Transduction
Signal Transduction
Positive Regulation Of Cell Population Proliferation
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Developmental Process
Regulation Of Intracellular Signal Transduction
Regulation Of Multicellular Organismal Process
Regulation Of Signal Transduction
Regulation Of Epithelial Cell Proliferation
Developmental Process
Cellular Developmental Process
Regulation Of Mitotic Cell Cycle
Regulation Of Signaling
Regulation Of Cell Communication
Regulation Of Cell Cycle
Regulation Of Apoptotic Process
Cell Population Proliferation
Regulation Of Programmed Cell Death
Regulation Of MAPK Cascade
Regulation Of Cellular Component Organization
Negative Regulation Of Apoptotic Process
Regulation Of Cell Differentiation
Negative Regulation Of Programmed Cell Death
Regulation Of Cell Adhesion
Cell Differentiation
Animal Organ Development
Negative Regulation Of Cell Differentiation
Regulation Of Fibroblast Proliferation
Positive Regulation Of Cell Migration
Intracellular Signal Transduction
Intracellular Signaling Cassette
Positive Regulation Of Cell Motility
Positive Regulation Of Locomotion
Regulation Of Growth
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Cellular Response To Epidermal Growth Factor Stimulus
Positive Regulation Of Epithelial Cell Proliferation
Regulation Of Cell Motility
Regulation Of Cell Development
Response To Epidermal Growth Factor
Positive Regulation Of Multicellular Organismal Process
Negative Regulation Of Developmental Process
Membrane
SNARE Complex
SNAP Receptor Activity
Protein Binding
Endoplasmic Reticulum Membrane
Vesicle Fusion
Organelle Fusion
Organelle Membrane Fusion
Membrane Fusion
Endoplasmic Reticulum
SNARE Binding
Membrane Organization
Localization Within Membrane
Vesicle Organization
Presynaptic Endosome Membrane
SNARE Complex Assembly
Mitochondrial Outer Membrane
Establishment Of Protein Localization To Membrane
Golgi Membrane
Endosome To Plasma Membrane Protein Transport
Positive Regulation Of Neutrophil Activation
Regulation Of Cellular Localization
Monoatomic Cation Transmembrane Transporter Activity
Vesicle-mediated Transport
Endomembrane System
Establishment Of Protein Localization To Plasma Membrane
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Tagcloud (Intersection)
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