PTPN18 and TEC

Number of citations of the paper that reports this interaction (PubMedID 14679216)
0

Data Source:
HPRD (in vitro)

		PTPN18	TEC
Description		protein tyrosine phosphatase non-receptor type 18	tec protein tyrosine kinase
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Membrane
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Non-membrane Spanning Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Phospholipid Binding Zinc Ion Binding Lipid Binding Kinase Activity Transferase Activity Metal Ion Binding
	Biological Process	Blastocyst Formation Protein Dephosphorylation Negative Regulation Of ERBB Signaling Pathway	Adaptive Immune Response Immune System Process Protein Phosphorylation Integrin-mediated Signaling Pathway Regulation Of Platelet Activation Intracellular Signal Transduction Tissue Regeneration T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway
Pathways		Downregulation of ERBB2 signaling Interleukin-37 signaling	Signaling by SCF-KIT FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization Interleukin-3, Interleukin-5 and GM-CSF signaling
Drugs			Fostamatinib Zanubrutinib
Diseases
GWAS			Crohn's disease ( 23128233) Metabolite levels ( 23823483) Pulse pressure ( 27841878) Rheumatoid arthritis ( 24390342 30423114) Systolic blood pressure ( 27841878)
Interacting Genes		14 interacting genes: AATK ABL1 ARHGAP5 CDK2 CNKSR1 CSK EGFR ERBB2 GAB1 PSTPIP1 PSTPIP2 SNCA SRC TEC	42 interacting genes: ARHGAP6 ARHGEF12 BMX BTK COMMD8 DOK1 EGFR ERBB2 ERBB3 ERBB4 FASLG FBXO7 GAB1 GABRB1 GNA12 IKBKG JAK1 JAK2 KIT LRRK1 LYN MET OTUD4 PIK3R1 PIK3R2 PIK3R3 PIP4K2A PIP5K1A PLCG1 PLCG2 PLK4 PRLR PRRG4 PTPN18 PTPN21 SHC1 SOCS1 STAP1 TP53 TXK VAV1 WAS
Entrez ID		26469	7006
HPRD ID		05961	02786
Ensembl ID		ENSG00000072135	ENSG00000135605
Uniprot IDs		Q99952	P42680
PDB IDs		2OC3 4GFU 4GFV 4NND	2LUL
Enriched GO Terms of Interacting Partners?		Protein Tyrosine Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway Protein Kinase Activity ERBB Signaling Pathway Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Perinuclear Region Of Cytoplasm Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway ERBB2 Signaling Pathway Intracellular Signal Transduction Cellular Response To Growth Factor Stimulus Regulation Of ERK1 And ERK2 Cascade ATP Binding Response To Growth Factor Cytoplasm SH2 Domain Binding Protein Phosphorylation Regulation Of Cell Activation Enzyme-linked Receptor Protein Signaling Pathway Phosphorylation Transferase Activity Nucleotide Binding Cell-cell Junction ERBB2-EGFR Signaling Pathway Protein Domain Specific Binding Immune Response-activating Cell Surface Receptor Signaling Pathway Signal Transduction Cytosol Cell Surface Receptor Signaling Pathway Cytoskeleton Plasma Membrane Integrin-mediated Signaling Pathway Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Response To Epinephrine Immune Response-regulating Cell Surface Receptor Signaling Pathway Ruffle Membrane Protein Tyrosine Kinase Activator Activity Positive Regulation Of Locomotion Neuron Apoptotic Process Negative Regulation Of Cell Adhesion T Cell Receptor Signaling Pathway Glial Cell Differentiation Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Endocytosis Proline-rich Region Binding Positive Regulation Of Phosphate Metabolic Process Regulation Of Locomotion Regulation Of Multicellular Organismal Process Regulation Of MAPK Cascade	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Tyrosine Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction Signal Transduction Regulation Of Signal Transduction Kinase Activity Regulation Of Cell Communication Regulation Of Signaling Regulation Of Intracellular Signal Transduction Intracellular Signaling Cassette Protein Kinase Activity Phosphotyrosine Residue Binding Positive Regulation Of Intracellular Signal Transduction Lymphocyte Activation Cellular Developmental Process Phosphate-containing Compound Metabolic Process Positive Regulation Of Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Mononuclear Cell Differentiation Regulation Of Programmed Cell Death Cytosol Protein Phosphorylation Leukocyte Activation ERBB Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Receptor Complex Positive Regulation Of Cell Communication Positive Regulation Of Signaling Leukocyte Differentiation Phosphorylation Negative Regulation Of Programmed Cell Death Peptidyl-tyrosine Phosphorylation Fc-epsilon Receptor Signaling Pathway Cell Activation Developmental Process Fc Receptor Signaling Pathway Lymphocyte Differentiation Regulation Of Immune System Process Regulation Of Locomotion Immune System Process B Cell Activation Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Differentiation Regulation Of Immune Response Phosphatidylinositol Metabolic Process T Cell Activation ATP Binding Positive Regulation Of Immune System Process
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