HSPB8 and HSPB3

Number of citations of the paper that reports this interaction (PubMedID 16225851)
0

Data Source:
BioGRID (two hybrid)

		HSPB8	HSPB3
Description		heat shock protein family B (small) member 8	heat shock protein family B (small) member 3
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Protein Folding Chaperone Complex	Nucleus Cytoplasm Nuclear Speck
	Molecular Function	Protein Kinase Activity Protein Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Cellular Response To Unfolded Protein Positive Regulation Of Aggrephagy	Response To Unfolded Protein
Pathways		HSF1-dependent transactivation
Drugs
Diseases		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy Distal hereditary motor neuropathies (dHMN)
GWAS		Metabolite levels ( 23823483) PR interval in Tripanosoma cruzi seropositivity ( 24324551)	Age-related cognitive decline (language) (slope of z-scores) ( 30954325) Systolic blood pressure (dietary potassium intake interaction) ( 29212900)
Interacting Genes		21 interacting genes: ATOSB ATXN7L2 BAG3 CATSPERT CRYAB CSNK2A1 DUSP12 HSPB1 HSPB2 HSPB3 HSPB6 HSPB7 MAPK3 MISP PRKCA QRICH1 RPIA SLC16A5 SNCA SOCS7 TRAPPC6A	19 interacting genes: ANP32A BBOX1 HSPB2 HSPB8 LRIF1 LSM14B MED31 MED8 MRPL38 NSMF OLFML3 PRP4K RAMP3 RBM48 RTL8A SETDB1 TCAP UNC119 ZZEF1
Entrez ID		26353	8988
HPRD ID		06420	06861
Ensembl ID		ENSG00000152137	ENSG00000169271
Uniprot IDs		Q9UJY1	Q12988 Q6ICS9
PDB IDs		8S7A	6F2R
Enriched GO Terms of Interacting Partners?		Response To Unfolded Protein Protein Refolding Response To Heat Protein Folding Response To Temperature Stimulus Structural Constituent Of Eye Lens Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Unfolded Protein Binding Positive Regulation Of Aggrephagy Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Regulation Of Protein Stability Regulation Of Autophagy Response To Stress Contractile Muscle Fiber Protein Transport Along Microtubule Protein Stabilization Positive Regulation Of Macroautophagy Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Negative Regulation Of Protein Catabolic Process Apoptotic Process Z Disc Negative Regulation Of Protein Metabolic Process Cell Death Programmed Cell Death Aggresome Negative Regulation Of Striated Muscle Cell Apoptotic Process Cytoplasm Positive Regulation Of Autophagy Positive Regulation Of Angiogenesis Negative Regulation Of Protein Kinase C Signaling Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Ribose-5-phosphate Isomerase Activity Positive Regulation Of Vasculature Development Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Nucleus Regulation Of Macroautophagy Response To Mechanical Stimulus
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