TTLL3 and CDCA5

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		TTLL3	CDCA5
Description		tubulin tyrosine ligase like 3	cell division cycle associated 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Microtubule Cilium Axoneme Microtubule Cytoskeleton Motile Cilium Sperm Flagellum Cell Projection	Chromosome, Centromeric Region Chromatin Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol
	Molecular Function	Nucleotide Binding ATP Binding Ligase Activity Metal Ion Binding Protein-glycine Ligase Activity Protein-glycine Ligase Activity, Initiating	Chromatin Binding Protein Binding Protein-containing Complex Binding
	Biological Process	Spermatogenesis Protein Polyglycylation Flagellated Sperm Motility Axoneme Assembly Cilium Assembly	Double-strand Break Repair Mitotic Sister Chromatid Cohesion Cell Division
Pathways		Carboxyterminal post-translational modifications of tubulin	Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion Resolution of Sister Chromatid Cohesion
Drugs		Theophylline
Diseases
GWAS
Interacting Genes		1 interacting genes: CDCA5	9 interacting genes: CDK1 IRAK3 KDM1A NAA11 RPAIN SENP2 TTLL3 WAPL XRCC6
Entrez ID		26140	113130
HPRD ID		15585	13016
Ensembl ID		ENSG00000214021	ENSG00000146670
Uniprot IDs		A0A8I5KXU2 J3KQB2 Q9Y4R7	Q96FF9
PDB IDs
Enriched GO Terms of Interacting Partners?		Mitotic Sister Chromatid Cohesion Sister Chromatid Cohesion	Protein Modification Process Regulation Of DNA Metabolic Process Regulation Of DNA Replication Chromosome, Telomeric Region Telomeric DNA Binding Cellular Response To Gamma Radiation Cyclin Binding Nucleoplasm Negative Regulation Of Metabolic Process Pronuclear Fusion Mitotic DNA-templated DNA Replication Cyclin B1-CDK1 Complex Chromosome Organization Negative Regulation Of Macromolecule Metabolic Process Cyclin A1-CDK1 Complex Cyclin A2-CDK1 Complex Response To Gamma Radiation Positive Regulation Of Protein Modification Process Cellular Response To Ionizing Radiation Positive Regulation Of Macrophage Tolerance Induction Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity ATP-dependent Protein-DNA Unloader Activity Negative Regulation Of Chromatin Binding Protein-glycine Ligase Activity, Initiating Protein Polyglycylation Protein-glycine Ligase Activity Protein-N-terminal-alanine Acetyltransferase Activity Protein-N-terminal-glutamate Acetyltransferase Activity Protein Localization To Chromosome Protein Metabolic Process Mitotic DNA Replication Muscle Cell Development DNA Synthesis Involved In Mitotic DNA Replication Cyclin-dependent Protein Kinase Activity Response To Toxic Substance DNA End Binding Response To Radiation Ku70:Ku80 Complex Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Positive Regulation Of Protein Ubiquitination PML Body Protein N-terminal-serine Acetyltransferase Activity Protein Modification By Small Protein Removal Regulation Of Schwann Cell Differentiation Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport Positive Regulation Of Post-translational Protein Modification Protein Demethylase Activity Regulation Of DNA Endoreduplication Nucleus
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