CDCA5 and WAPL

Number of citations of the paper that reports this interaction (PubMedID 31010829)
40

Data Source:
BioGRID (affinity chromatography technology, pull down)

		CDCA5	WAPL
Description		cell division cycle associated 5	WAPL cohesin release factor
Image		No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Chromatin Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol	Chromosome, Centromeric Region Chromatin Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Intercellular Bridge Mitotic Spindle
	Molecular Function	Chromatin Binding Protein Binding Protein-containing Complex Binding	Protein Binding ATP-dependent Protein-DNA Unloader Activity
	Biological Process	Double-strand Break Repair Mitotic Sister Chromatid Cohesion Cell Division	Mitotic Sister Chromatid Segregation Negative Regulation Of DNA Replication Negative Regulation Of Chromatin Binding Negative Regulation Of Sister Chromatid Cohesion Cell Division Protein Localization To Chromatin
Pathways		Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion Resolution of Sister Chromatid Cohesion	Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion Cohesin Loading onto Chromatin Resolution of Sister Chromatid Cohesion
Drugs
Diseases
GWAS			Parental longevity (father's age at death) ( 31484785)
Interacting Genes		9 interacting genes: CDK1 IRAK3 KDM1A NAA11 RPAIN SENP2 TTLL3 WAPL XRCC6	7 interacting genes: ARAP1 BTG3 CDCA5 MTNR1A RAD21 SUMO2 XRN1
Entrez ID		113130	23063
HPRD ID		13016	11072
Ensembl ID		ENSG00000146670	ENSG00000062650
Uniprot IDs		Q96FF9	A8K273 B2RTX8 Q7Z5K2
PDB IDs			4K6J 5HDT
Enriched GO Terms of Interacting Partners?		Protein Modification Process Regulation Of DNA Metabolic Process Regulation Of DNA Replication Chromosome, Telomeric Region Telomeric DNA Binding Cellular Response To Gamma Radiation Cyclin Binding Nucleoplasm Negative Regulation Of Metabolic Process Pronuclear Fusion Mitotic DNA-templated DNA Replication Cyclin B1-CDK1 Complex Chromosome Organization Negative Regulation Of Macromolecule Metabolic Process Cyclin A1-CDK1 Complex Cyclin A2-CDK1 Complex Response To Gamma Radiation Positive Regulation Of Protein Modification Process Cellular Response To Ionizing Radiation Positive Regulation Of Macrophage Tolerance Induction Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity ATP-dependent Protein-DNA Unloader Activity Negative Regulation Of Chromatin Binding Protein-glycine Ligase Activity, Initiating Protein Polyglycylation Protein-glycine Ligase Activity Protein-N-terminal-alanine Acetyltransferase Activity Protein-N-terminal-glutamate Acetyltransferase Activity Protein Localization To Chromosome Protein Metabolic Process Mitotic DNA Replication Muscle Cell Development DNA Synthesis Involved In Mitotic DNA Replication Cyclin-dependent Protein Kinase Activity Response To Toxic Substance DNA End Binding Response To Radiation Ku70:Ku80 Complex Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Positive Regulation Of Protein Ubiquitination PML Body Protein N-terminal-serine Acetyltransferase Activity Protein Modification By Small Protein Removal Regulation Of Schwann Cell Differentiation Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport Positive Regulation Of Post-translational Protein Modification Protein Demethylase Activity Regulation Of DNA Endoreduplication Nucleus	Sister Chromatid Cohesion Negative Regulation Of Chromosome Organization Cellular Response To Puromycin Cellular Response To Cycloheximide
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