LTN1 and IRF7

Number of citations of the paper that reports this interaction (PubMedID 21903422)
55

Data Source:
BioGRID (affinity chromatography technology, pull down)

		LTN1	IRF7
Description		listerin E3 ubiquitin protein ligase 1	interferon regulatory factor 7
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GO Annotations	Cellular Component	Cytoplasm Cytosol Cytosolic Ribosome RQC Complex	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Endosome Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ribosomal Large Subunit Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Protein Ubiquitination Protein Autoubiquitination Rescue Of Stalled Ribosome Ribosome-associated Ubiquitin-dependent Protein Catabolic Process	Negative Regulation Of Transcription By RNA Polymerase II Immune System Process Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of Adaptive Immune Response Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II DNA Damage Response Signal Transduction Response To Virus Regulation Of Gene Expression Immunoglobulin Mediated Immune Response Establishment Of Viral Latency Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Regulation Of MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway MDA-5 Signaling Pathway Innate Immune Response Positive Regulation Of Innate Immune Response Regulation Of Monocyte Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Immune Response Defense Response To Virus Type I Interferon-mediated Signaling Pathway Positive Regulation Of Type I Interferon-mediated Signaling Pathway Negative Regulation Of Macrophage Apoptotic Process
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	DEx/H-box helicases activate type I IFN and inflammatory cytokines production Interferon gamma signaling TICAM1-dependent activation of IRF3/IRF7 Interferon alpha/beta signaling TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) SARS-CoV-2 activates/modulates innate and adaptive immune responses TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
Drugs
Diseases
GWAS		High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Hip circumference ( 28552196) Immature fraction of reticulocytes ( 32888494) Initial pursuit acceleration in psychotic disorders ( 29064472) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 27863252 32888494)	Systemic lupus erythematosus ( 26502338 27399966 28714469) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic sclerosis ( 31672989)
Interacting Genes		10 interacting genes: AGO1 HES4 IRF7 STING1 TIRAP UBC UBE2D1 UBE2D2 UBE2L3 USP16	28 interacting genes: ACADS AIP ARAF CCDC47 CDK4 CREBBP EP300 GCLM INSR IRAK1 IRF3 KAT2A KAT2B LTN1 MAVS MYD88 PALD1 PIAS4 SOCS1 SOCS3 TBK1 TICAM1 TICAM2 TLK2 TP53 TRAF6 TRIM28 TRMT61B
Entrez ID		26046	3665
HPRD ID		10327	05441
Ensembl ID		ENSG00000198862	ENSG00000185507
Uniprot IDs		O94822	B4E1B1 M9RSF4 Q92985
PDB IDs		3J92	2O61
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Regulation Of Interferon-beta Production Positive Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Type I Interferon Production Post-translational Protein Modification Regulation Of RNA Metabolic Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signaling Pathway Regulation Of Nucleobase-containing Compound Metabolic Process Macromolecule Catabolic Process Nucleoplasm Regulation Of Type I Interferon-mediated Signaling Pathway Positive Regulation Of Interferon-beta Production Activation Of Innate Immune Response Catabolic Process Protein Ubiquitination Proteolysis Modification-dependent Protein Catabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Positive Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Gene Expression Positive Regulation Of Innate Immune Response Regulation Of RNA Biosynthetic Process Proteolysis Involved In Protein Catabolic Process Ubiquitin Protein Ligase Binding Protein Modification By Small Protein Conjugation Protein Polyubiquitination Ubiquitin-protein Transferase Activity Transcription Coactivator Activity Positive Regulation Of Ribosome Biogenesis Positive Regulation Of Pattern Recognition Receptor Signaling Pathway TIRAP-dependent Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Interleukin-15 Production Cyclic-di-GMP Binding STING Complex Positive Regulation Of Response To Cytokine Stimulus Regulation Of Gene Expression Positive Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Immune Response-activating Signaling Pathway Signaling Adaptor Activity Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway Regulation Of Primary Metabolic Process Establishment Of Viral Latency Regulation Of Transcription By RNA Polymerase II Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway 2',3'-cyclic GMP-AMP Binding Positive Regulation Of Type I Interferon Production Protein Modification Process	Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Innate Immune Response-activating Signaling Pathway Toll-like Receptor 4 Signaling Pathway Activation Of Innate Immune Response Cell Surface Toll-like Receptor Signaling Pathway Positive Regulation Of Type I Interferon Production Cell Surface Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Innate Immune Response Regulation Of Type I Interferon Production Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Immune Response-activating Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Cytoplasmic Pattern Recognition Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Activation Of Immune Response Regulation Of Innate Immune Response Interferon-mediated Signaling Pathway Positive Regulation Of Defense Response TRIF-dependent Toll-like Receptor Signaling Pathway Cellular Response To Oxygen-containing Compound Peptidyl-lysine Acetylation Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Lipopolysaccharide-mediated Signaling Pathway Protein Modification Process MyD88-independent Toll-like Receptor Signaling Pathway Cellular Response To Lipopolysaccharide Transferase Activity Cytokine-mediated Signaling Pathway Intracellular Signal Transduction Cellular Response To Molecule Of Bacterial Origin Acetyltransferase Activity Type I Interferon-mediated Signaling Pathway Regulation Of Defense Response Canonical NF-kappaB Signal Transduction MRNA Transcription Macromolecule Metabolic Process Transcription Coregulator Activity Positive Regulation Of Immune Response Histone Acetyltransferase Complex Intracellular Receptor Signaling Pathway Protein-lysine-acetyltransferase Activity Positive Regulation Of Cytokine Production Cell Surface Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Endolysosomal Toll-like Receptor Signaling Pathway
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