LTN1 and TIRAP

Number of citations of the paper that reports this interaction (PubMedID 21903422)
55

Data Source:
BioGRID (pull down)

		LTN1	TIRAP
Description		listerin E3 ubiquitin protein ligase 1	TIR domain containing adaptor protein
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GO Annotations	Cellular Component	Cytoplasm Cytosol Cytosolic Ribosome RQC Complex	Cytoplasm Cytosol Plasma Membrane Cell Surface Membrane Endocytic Vesicle Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Ruffle Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ribosomal Large Subunit Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Kinase C Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Protein-macromolecule Adaptor Activity Signaling Adaptor Activity Toll-like Receptor 4 Binding Toll-like Receptor 2 Binding Identical Protein Binding Molecular Adaptor Activity
	Biological Process	Protein Ubiquitination Protein Autoubiquitination Rescue Of Stalled Ribosome Ribosome-associated Ubiquitin-dependent Protein Catabolic Process	Immune System Process MyD88-dependent Toll-like Receptor Signaling Pathway Inflammatory Response Signal Transduction Cell Surface Receptor Signaling Pathway Myeloid Cell Differentiation Positive Regulation Of B Cell Proliferation Positive Regulation Of Protein-containing Complex Assembly Response To Lipopolysaccharide Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-15 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Positive Regulation Of Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Toll-like Receptor 4 Signaling Pathway TIRAP-dependent Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Regulation Of Innate Immune Response Positive Regulation Of JNK Cascade Defense Response To Gram-positive Bacterium Positive Regulation Of ERK1 And ERK2 Cascade 3'-UTR-mediated MRNA Stabilization Cellular Response To Bacterial Lipopeptide Cellular Response To Lipoteichoic Acid Positive Regulation Of Neutrophil Chemotaxis Positive Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	ER-Phagosome pathway MyD88:MAL(TIRAP) cascade initiated on plasma membrane MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4)
Drugs
Diseases
GWAS		High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Hip circumference ( 28552196) Immature fraction of reticulocytes ( 32888494) Initial pursuit acceleration in psychotic disorders ( 29064472) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 27863252 32888494)	Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Eosinophil percentage of granulocytes ( 27863252) Neutrophil percentage of granulocytes ( 27863252)
Interacting Genes		10 interacting genes: AGO1 HES4 IRF7 STING1 TIRAP UBC UBE2D1 UBE2D2 UBE2L3 USP16	25 interacting genes: APP ARAF BTK CASP1 CCDC47 CD247 DNAJC3 EIF2AK2 IL1RL1 IRAK2 IRAK4 LRRK1 LTN1 MPP3 MYD88 PCNA PRKRA SAMHD1 SOCS1 TICAM1 TICAM2 TLR2 TLR4 TRAF6 TRAM1
Entrez ID		26046	114609
HPRD ID		10327	05878
Ensembl ID		ENSG00000198862	ENSG00000150455
Uniprot IDs		O94822	P58753
PDB IDs		3J92	2NDH 2Y92 3UB2 3UB3 3UB4 4FZ5 4LQD 5T7Q 5UZB 8JZM
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Regulation Of Interferon-beta Production Positive Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Type I Interferon Production Post-translational Protein Modification Regulation Of RNA Metabolic Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signaling Pathway Regulation Of Nucleobase-containing Compound Metabolic Process Macromolecule Catabolic Process Nucleoplasm Regulation Of Type I Interferon-mediated Signaling Pathway Positive Regulation Of Interferon-beta Production Activation Of Innate Immune Response Catabolic Process Protein Ubiquitination Proteolysis Modification-dependent Protein Catabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Positive Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Gene Expression Positive Regulation Of Innate Immune Response Regulation Of RNA Biosynthetic Process Proteolysis Involved In Protein Catabolic Process Ubiquitin Protein Ligase Binding Protein Modification By Small Protein Conjugation Protein Polyubiquitination Ubiquitin-protein Transferase Activity Transcription Coactivator Activity Positive Regulation Of Ribosome Biogenesis Positive Regulation Of Pattern Recognition Receptor Signaling Pathway TIRAP-dependent Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Interleukin-15 Production Cyclic-di-GMP Binding STING Complex Positive Regulation Of Response To Cytokine Stimulus Regulation Of Gene Expression Positive Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Immune Response-activating Signaling Pathway Signaling Adaptor Activity Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway Regulation Of Primary Metabolic Process Establishment Of Viral Latency Regulation Of Transcription By RNA Polymerase II Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway 2',3'-cyclic GMP-AMP Binding Positive Regulation Of Type I Interferon Production Protein Modification Process	Toll-like Receptor Signaling Pathway Cell Surface Toll-like Receptor Signaling Pathway Cell Surface Pattern Recognition Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Innate Immune Response-activating Signaling Pathway Positive Regulation Of Chemokine Production Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Activation Of Innate Immune Response Toll-like Receptor 4 Signaling Pathway Regulation Of Innate Immune Response Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Defense Response Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-activating Signaling Pathway Regulation Of Chemokine Production Defense Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Activation Of Immune Response Regulation Of Immune Response Positive Regulation Of Innate Immune Response Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Immune System Process Regulation Of Defense Response Innate Immune Response Positive Regulation Of Type I Interferon Production Positive Regulation Of Cytokine Production Response To Other Organism Positive Regulation Of Interleukin-6 Production Positive Regulation Of Intracellular Signal Transduction Immune Response Defense Response To Symbiont Defense Response To Virus Defense Response To Other Organism Interleukin-33-mediated Signaling Pathway Immune System Process Interleukin-1-mediated Signaling Pathway Regulation Of Cytokine Production Regulation Of Immune System Process Response To External Biotic Stimulus Response To Stress Regulation Of Type I Interferon Production Positive Regulation Of Immune Response TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Interleukin-6 Production Response To Virus MyD88-independent Toll-like Receptor Signaling Pathway
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