UBXN7 and ATP13A3

		UBXN7	ATP13A3
Description		UBX domain protein 7	ATPase 13A3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol VCP-NPL4-UFD1 AAA ATPase Complex	Endosome Membrane Early Endosome Membrane Late Endosome Membrane Recycling Endosome Membrane
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding Ubiquitin Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	Nucleotide Binding ATP Binding Polyamine Transmembrane Transporter Activity ABC-type Putrescine Transporter Activity P-type Ion Transporter Activity ATP Hydrolysis Activity ATPase-coupled Monoatomic Cation Transmembrane Transporter Activity Metal Ion Binding P-type Transmembrane Transporter Activity
	Biological Process	Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Intracellular Calcium Ion Homeostasis Putrescine Transport Transmembrane Transport Monoatomic Cation Transmembrane Transport Polyamine Transmembrane Transport
Pathways		Neddylation KEAP1-NFE2L2 pathway
Drugs
Diseases
GWAS		Adult body size ( 32376654) Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) IgM levels ( 28628107)	Red blood cell count ( 32888494) White blood cell count (basophil) ( 29403010)
Interacting Genes		35 interacting genes: APP ATP13A3 CLEC19A CRX CYSRT1 DAZAP2 FAM120A FAM168A FLG IGF2BP1 IGF2BP2 IGF2BP3 LARP1 MAP3K1 MEOX1 MTDH MUL1 NEDD8 NFYC PABPC4 PAX5 PAX6 REL RNF111 RPS3 RPS3A SMURF1 TRAF6 TRIM39 TRIM62 TRIM8 UBC UBQLN1 UBQLN2 ZNRF1	2 interacting genes: PIGX UBXN7
Entrez ID		26043	79572
HPRD ID		19396	10636
Ensembl ID		ENSG00000163960	ENSG00000133657
Uniprot IDs		O94888	A0A2R8Y635 Q9H7F0
PDB IDs		1WJ4 2DAL 2DLX 5X3P 5X4L
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Macromolecule Metabolic Process MRNA 5'-UTR Binding Positive Regulation Of Metabolic Process Protein Metabolic Process Regulation Of Primary Metabolic Process Cytoplasmic Stress Granule Protein Ubiquitination Regulation Of Macromolecule Metabolic Process Ubiquitin Protein Ligase Activity Regulation Of Protein Metabolic Process Protein Modification By Small Protein Conjugation Protein Polyubiquitination CRD-mediated MRNA Stabilization N6-methyladenosine-containing RNA Reader Activity Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Base-excision Repair Macromolecule Metabolic Process Post-translational Protein Modification Positive Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction MRNA 3'-UTR Binding Translation Regulator Activity Cytosol Regulation Of RNA Metabolic Process Regulation Of Proteolysis MRNA Stabilization Positive Regulation Of Catabolic Process Modification-dependent Protein Catabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of MRNA Catabolic Process RNA Stabilization NF-kappaB Complex Regulation Of Base-excision Repair Positive Regulation Of Protein Metabolic Process Negative Regulation Of Translation Nucleus Regulation Of MRNA Stability Negative Regulation Of RNA Catabolic Process Regulation Of Gene Expression Protein Modification Process Proteolysis Involved In Protein Catabolic Process Negative Regulation Of MRNA Metabolic Process Cytoplasm Regulation Of RNA Stability Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process
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