UBXN7 and FLG

Number of citations of the paper that reports this interaction (PubMedID 37744330)
51

Data Source:
BioGRID (unspecified method)

		UBXN7	FLG
Description		UBX domain protein 7	filaggrin
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol VCP-NPL4-UFD1 AAA ATPase Complex	Cornified Envelope Nucleus Cytosol Extracellular Matrix Keratohyalin Granule Cytoplasmic Ribonucleoprotein Granule
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding Ubiquitin Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	Structural Molecule Activity Calcium Ion Binding Protein Binding Structural Constituent Of Skin Epidermis Metal Ion Binding Transition Metal Ion Binding
	Biological Process	Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Peptide Cross-linking Keratinocyte Differentiation Establishment Of Skin Barrier
Pathways		Neddylation KEAP1-NFE2L2 pathway	Formation of the cornified envelope Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin
Drugs
Diseases			Ichthyosis vulgaris
GWAS		Adult body size ( 32376654) Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) IgM levels ( 28628107)	Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Asthma ( 30929738 34103634 32296059 31959851 31619474 31361310) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Asthma (moderate or severe) ( 30552067) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 21666691 26482879 25574825 23886662) Atopic march ( 26542096) Eating disorders ( 23568457) Eczema ( 31361310) Male-pattern baldness ( 28196072)
Interacting Genes		35 interacting genes: APP ATP13A3 CLEC19A CRX CYSRT1 DAZAP2 FAM120A FAM168A FLG IGF2BP1 IGF2BP2 IGF2BP3 LARP1 MAP3K1 MEOX1 MTDH MUL1 NEDD8 NFYC PABPC4 PAX5 PAX6 REL RNF111 RPS3 RPS3A SMURF1 TRAF6 TRIM39 TRIM62 TRIM8 UBC UBQLN1 UBQLN2 ZNRF1	5 interacting genes: CSNK2A1 PCSK6 UBXN7 UCHL5 WEE2-AS1
Entrez ID		26043	2312
HPRD ID		19396	15920
Ensembl ID		ENSG00000163960	ENSG00000143631
Uniprot IDs		O94888	P20930
PDB IDs		1WJ4 2DAL 2DLX 5X3P 5X4L	4PCW
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Macromolecule Metabolic Process MRNA 5'-UTR Binding Positive Regulation Of Metabolic Process Protein Metabolic Process Regulation Of Primary Metabolic Process Cytoplasmic Stress Granule Protein Ubiquitination Regulation Of Macromolecule Metabolic Process Ubiquitin Protein Ligase Activity Regulation Of Protein Metabolic Process Protein Modification By Small Protein Conjugation Protein Polyubiquitination CRD-mediated MRNA Stabilization N6-methyladenosine-containing RNA Reader Activity Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Base-excision Repair Macromolecule Metabolic Process Post-translational Protein Modification Positive Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction MRNA 3'-UTR Binding Translation Regulator Activity Cytosol Regulation Of RNA Metabolic Process Regulation Of Proteolysis MRNA Stabilization Positive Regulation Of Catabolic Process Modification-dependent Protein Catabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of MRNA Catabolic Process RNA Stabilization NF-kappaB Complex Regulation Of Base-excision Repair Positive Regulation Of Protein Metabolic Process Negative Regulation Of Translation Nucleus Regulation Of MRNA Stability Negative Regulation Of RNA Catabolic Process Regulation Of Gene Expression Protein Modification Process Proteolysis Involved In Protein Catabolic Process Negative Regulation Of MRNA Metabolic Process Cytoplasm Regulation Of RNA Stability Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process	Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Negative Regulation Of Protein Catabolic Process Nerve Growth Factor Production Zygotic Determination Of Anterior/posterior Axis, Embryo Protein Kinase CK2 Complex Regulation Of Ubiquitin-dependent Protein Catabolic Process Symbiont-mediated Disruption Of Host Cell PML Body Pre-mRNA 5'-splice Site Binding Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Aggrephagy Nerve Growth Factor Binding Macromolecule Catabolic Process Regulation Of DNA Repair DNA Recombination MRNA 5'-splice Site Recognition VCP-NPL4-UFD1 AAA ATPase Complex Forebrain Morphogenesis Proteolysis Anterior/posterior Axis Specification, Embryo Double-strand Break Repair Via Classical Nonhomologous End Joining Aggrephagy Protein Targeting To Vacuole Involved In Autophagy Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Protein Metabolic Process Positive Regulation Of Telomere Maintenance In Response To DNA Damage Lateral Ventricle Development Regulation Of Protein Catabolic Process Negative Regulation Of Catabolic Process Regulation Of Proteolysis Regulation Of DNA Strand Elongation Ino80 Complex MRNA Methylguanosine-cap Decapping Proteasome Binding U1 SnRNP RNA Decapping Sin3-type Complex Peptidase Activity
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