MAGI3 and DSCAML1

Number of citations of the paper that reports this interaction (PubMedID 12421765)
39

Data Source:
HPRD (two hybrid)

		MAGI3	DSCAML1
Description		membrane associated guanylate kinase, WW and PDZ domain containing 3	DS cell adhesion molecule like 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Cell-cell Junction Bicellular Tight Junction Membrane Cell Junction Anchoring Junction	Extracellular Space Plasma Membrane Cell Surface Membrane Axon Synapse
	Molecular Function	Nucleotide Binding GMP Kinase Activity Frizzled Binding Protein Binding ATP Binding	Protein Homodimerization Activity Cell-cell Adhesion Mediator Activity
	Biological Process	Apoptotic Process Signal Transduction Intracellular Signal Transduction GMP Metabolic Process GDP Metabolic Process	Cell Fate Determination Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Nervous System Development Axonogenesis Axon Guidance Central Nervous System Development Brain Development Dorsal/ventral Pattern Formation Embryonic Skeletal System Morphogenesis Dendrite Self-avoidance
Pathways			DSCAM interactions
Drugs
Diseases
GWAS		Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081) Alopecia areata ( 25608926) Autoimmune thyroid disease ( 32581359) Bacteremia ( 27236921) Bulimia nervosa ( 23568457) Cerebrospinal fluid clusterin levels ( 26545630) Cognitive decline rate in late mild cognitive impairment ( 26252872) Crohn's disease ( 28067908) Femur bone mineral density x serum urate levels interaction ( 34046847) Gut microbiota (bacterial taxa) ( 27694959) Leukocyte telomere length ( 32109421) Lung cancer ( 31577861) Myocardial infarction ( 33532862) Neuroblastoma or malignant cutaneous melanoma ( 31605138) Obesity-related traits ( 23251661) Parental lifespan ( 30642433) Type 1 diabetes and autoimmune thyroid diseases ( 25936594)	Hippocampal volume in Alzheimer's disease dementia ( 29274321) Lipoprotein (a) - cholesterol levels ( 25575512) Menarche (age at onset) ( 23599027) Myopia ( 27182965) Putamen volume ( 29147026) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Triglyceride levels ( 28548082) Triglycerides ( 19074352 30275531) Very low density lipoprotein cholesterol levels ( 28548082)
Interacting Genes		24 interacting genes: ADGRB1 ADRB1 BRSK2 CDK16 CRHR1 DSCAM DSCAML1 ERBB4 FMR1 FZD4 FZD7 GRIN2B LATS1 MECOM NRCAM PLXNB3 PRRG4 PTEN PTPRB RPS6KA1 RUNX1 TGFA TNK2 VANGL2	4 interacting genes: DYRK1A MAGI2 MAGI3 PLCL2
Entrez ID		260425	57453
HPRD ID		11290	10921
Ensembl ID		ENSG00000081026	ENSG00000177103
Uniprot IDs		Q5TCQ9	A0A384DVL8 Q8TD84
PDB IDs		3SOE	1VA9
Enriched GO Terms of Interacting Partners?		Developmental Process Regulation Of Developmental Process Plasma Membrane PDZ Domain Binding Regulation Of Cellular Component Organization Regulation Of Developmental Growth Synapse Cell-cell Adhesion Mediator Activity Synapse Assembly Postsynaptic Density Membrane System Development Nervous System Development Regulation Of Cell Communication Regulation Of Growth Regulation Of Signaling Regulation Of Biological Quality Neuron Projection Morphogenesis Cell Projection Morphogenesis Regulation Of Plasma Membrane Bounded Cell Projection Organization Axonogenesis Regulation Of Cell Projection Organization Signal Transduction Negative Regulation Of Cell Adhesion Cell Surface Receptor Signaling Pathway Cellular Developmental Process Neuron Projection Regulation Of Multicellular Organismal Process Neuron Differentiation Regulation Of Organ Growth Cardiac Muscle Tissue Regeneration Phosphorylation Anatomical Structure Morphogenesis Regulation Of Anatomical Structure Morphogenesis Epidermal Growth Factor Receptor Binding Regulation Of Phosphorylation Regulation Of Cell Differentiation Cell Differentiation Cell Recognition Regulation Of Nervous System Development Regulation Of Neuron Projection Development Synapse Organization Cell Junction Assembly Regulation Of Synaptic Vesicle Clustering Positive Regulation Of Nervous System Development Neuron Recognition Hepatocyte Proliferation Neuron Projection Development Positive Regulation Of Developmental Process Regulation Of Axonogenesis Non-canonical Wnt Signaling Pathway	Negative Regulation Of Signal Transduction RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Phosphate-containing Compound Metabolic Process Negative Regulation Of Cell Communication Negative Regulation Of Heterochromatin Formation Regulation Of Neurofibrillary Tangle Assembly Neurofilament Negative Regulation Of Signaling Splicing Factor Binding Regulation Of Heterochromatin Formation Histone H3T45 Kinase Activity Podocyte Development Cell-cell Junction Beta-1 Adrenergic Receptor Binding Slit Diaphragm Type II Activin Receptor Binding Bicellular Tight Junction B Cell Proliferation Involved In Immune Response B-1a B Cell Differentiation Negative Regulation Of B Cell Receptor Signaling Pathway B-1 B Cell Differentiation GMP Kinase Activity GDP Metabolic Process Inositol 1,4,5 Trisphosphate Binding Negative Regulation Of Microtubule Polymerization Nerve Growth Factor Signaling Pathway Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Activin Receptor Signaling Pathway GABA Receptor Binding Dendrite Intracellular Signal Transduction Tau-protein Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Negative Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Chromatin Organization Nervous System Development Negative Regulation Of RNA Splicing Regulation Of Inclusion Body Assembly Neurotrophin Signaling Pathway Positive Regulation Of Receptor Internalization SMAD Protein Signal Transduction Regulation Of Activin Receptor Signaling Pathway Regulation Of B Cell Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Gamma-aminobutyric Acid Signaling Pathway Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity GMP Metabolic Process Clathrin-dependent Endocytosis Signaling Receptor Complex Adaptor Activity Wnt Signaling Pathway, Planar Cell Polarity Pathway
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