RNF167 and PTN

Number of citations of the paper that reports this interaction (PubMedID 36178190)
90

Data Source:
BioGRID (pull down)

		RNF167	PTN
Description		ring finger protein 167	pleiotrophin
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Lysosome Lysosomal Membrane Endosome Cytosol Plasma Membrane Endosome Membrane Endomembrane System Membrane Organelle Membrane Endolysosome Membrane	Extracellular Region Extracellular Space Endoplasmic Reticulum Plasma Membrane Protein-containing Complex Schaffer Collateral - CA1 Synapse
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Phosphatase Inhibitor Activity Integrin Binding Protein Binding Growth Factor Activity Heparin Binding Protein Kinase Binding Carbohydrate Binding Chondroitin Sulfate Binding Molecular Function Activator Activity
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Cellular Response To Nutrient Levels Lysosome Localization Cellular Response To Amino Acid Starvation Protein K29-linked Ubiquitination Negative Regulation Of Cell Cycle Organelle Localization Regulation Of Synaptic Transmission, Glutamatergic Protein K63-linked Ubiquitination Protein K6-linked Ubiquitination Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Cellular Response To Leucine Starvation	Ossification Leukocyte Chemotaxis Involved In Inflammatory Response Positive Regulation Of Leukocyte Chemotaxis Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Integrin-mediated Signaling Pathway Nervous System Development Negative Regulation Of Neuroblast Proliferation Learning Memory Positive Regulation Of Cell Population Proliferation Regulation Of Endothelial Cell Migration Positive Regulation Of Neuron Projection Development Response To Auditory Stimulus Bone Mineralization Positive Regulation Of Bone Mineralization Dendrite Regeneration Regulation Of Myelination Tissue Regeneration Receptor Clustering Ossification Involved In Bone Remodeling Estrous Cycle Positive Regulation Of Cell Differentiation Positive Regulation Of Ossification Decidualization Regulation Of Synaptic Plasticity Oogenesis Positive Regulation Of Axon Regeneration Positive Regulation Of Oligodendrocyte Differentiation Modulation Of Chemical Synaptic Transmission Positive Regulation Of Cell Division Dendrite Arborization Positive Regulation Of Dendrite Development Negative Regulation Of Long-term Synaptic Potentiation Regulation Of Hemopoiesis Regulation Of Stem Cell Population Maintenance Positive Regulation Of Hepatocyte Proliferation Positive Regulation Of Stem Cell Differentiation
Pathways			Signaling by ALK Signaling by ALK MDK and PTN in ALK signaling MDK and PTN in ALK signaling
Drugs
Diseases
GWAS		Keratoconus ( 33649486) Platelet count ( 32888494) Plateletcrit ( 32888494)	Aluminium levels ( 26025379) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Blood protein levels ( 30072576) Metabolite levels ( 23823483) Neurociticism ( 29500382) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Schizophrenia ( 25056061 29483656)
Interacting Genes		34 interacting genes: ACTA1 AFG3L2 ATP2A1 CAPN3 CDC34 EGFR GRIA2 MDK MYH7 PDCD1 PTN RAB7A SESN2 SLC67A1 SUMO1 TAFA2 TAFA5 TMEM97 TOLLIP TTN UBE2A UBE2B UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E3 UBE2G2 UBE2K UBE2N UBE2T UBE2W	101 interacting genes: ACTB ALK APOBEC3G ARIH2 ARL15 ASPH ATP5F1C ATRX BAG6 BARD1 BCCIP BCL2L1 BLOC1S1 BMI1 BTBD2 C11orf58 C7orf25 CAAP1 CACNB4 CAPZB CDH10 CDK5RAP2 CGA CHD3 COX6C CRCT1 CRELD1 CSTA CYP2E1 DNAJB11 DUSP12 EIF3F EVA1A FEZ1 FTL GADD45A GADD45G GIPC2 GLYAT GPD1 GPRASP2 GSDME GSK3B GSTP1 GTF2F1 HGH1 HSPBAP1 ITSN2 KPNB1 LAMA4 LUC7L2 MAD2L1BP MFRP MKKS MLLT3 MRPL44 MYCBP NAP1L5 NCAN NEK6 NUDT21 P4HB PFDN1 PIAS4 PLXNB2 PMF1 PPP2CA PSMB10 PSMD11 PSMD2 PTPRS PTPRZ1 RACK1 RBM23 RIT1 RNF167 ROR1 RPLP1 SAT1 SDC1 SDC3 SGSM2 SGTA SLC25A36 SNCAIP SPIN1 SSR1 STC2 SUPT7L TAC3 TAF1D TBRG4 TOMM20 TP53BP2 TSC22D1 TXNDC9 UBQLN1 UBQLN4 UTP3 WASHC3 WFDC2
Entrez ID		26001	5764
HPRD ID		15261	01199
Ensembl ID		ENSG00000108523	ENSG00000105894
Uniprot IDs		Q9H6Y7	A0A8V8TNI1 P21246
PDB IDs			2N6F 8VOH 8VOI
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein K48-linked Ubiquitination Protein Polyubiquitination Ubiquitin-protein Transferase Activity Protein Modification By Small Protein Conjugation ATP Binding Protein Ubiquitination Protein K11-linked Ubiquitination Nucleotide Binding Post-translational Protein Modification Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Macromolecule Catabolic Process Proteolysis Ubiquitin Protein Ligase Binding Protein Monoubiquitination Protein Catabolic Process Protein Modification Process Catabolic Process Transferase Activity Protein Metabolic Process Protein K63-linked Ubiquitination Ubiquitin-like Protein Transferase Activity Protein K6-linked Ubiquitination Proteasomal Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Modification Process Regulation Of Post-translational Protein Modification Negative Regulation Of TORC1 Signaling DNA Metabolic Process Protein Autoubiquitination Cellular Response To Interferon-beta Positive Regulation Of Protein Metabolic Process Cellular Response To Stress Negative Regulation Of TOR Signaling HULC Complex Response To Interferon-beta Regulation Of TORC1 Signaling Macromolecule Metabolic Process Postreplication Repair Skeletal Muscle Thin Filament Assembly DNA Repair Free Ubiquitin Chain Polymerization Positive Regulation Of Protein Modification Process Protein-containing Complex Regulation Of Protein Metabolic Process Leukocyte Chemotaxis Involved In Inflammatory Response DNA Damage Response Positive Regulation Of Post-translational Protein Modification	Regulation Of Cellular Response To Stress
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