GAMT and RAB24

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GAMT	RAB24
Description		guanidinoacetate N-methyltransferase	RAB24, member RAS oncogene family
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Autophagosome Membrane Cytoplasm Mitochondrion Endosome Autophagosome Spindle Cytosol Cytoskeleton Plasma Membrane Endomembrane System Membrane Endocytic Vesicle Secretory Granule Membrane Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Methyltransferase Activity Transferase Activity Guanidinoacetate N-methyltransferase Activity	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Creatine Metabolic Process Creatine Biosynthetic Process Muscle Contraction Spermatogenesis Animal Organ Morphogenesis Methylation Regulation Of Multicellular Organism Growth	Oocyte Maturation Intracellular Protein Transport Autophagy Attachment Of Spindle Microtubules To Kinetochore Protein Transport Meiotic Nuclear Division
Pathways		Creatine metabolism Transcriptional Regulation by MECP2	Neutrophil degranulation RAB geranylgeranylation
Drugs		Creatine Guanidine S-adenosyl-L-homocysteine Glycocyamine Phosphocreatine
Diseases		Guanidinoacetate methyltransferase (GAMT) deficiency Creatine deficiency syndrome, including: Arginine:glycine amidinotransferase deficiency (AGAT deficiency); Guanidinoacetate methyltransferase deficiency (GAMT deficiency); X-linked creatine deficiency syndrome (XL-CDS)
GWAS			Anthropometric traits ( 30166351) Anthropometric traits (multi-trait analysis) ( 30166351) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Narrowest width of the femoral neck ( 30888730) Waist circumference adjusted for body mass index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		10 interacting genes: CSNK2B FOS GPX4 LCOR POT1 RAB24 RSPH1 TERF1 TERF2IP TRIM39	4 interacting genes: CRYAA GAMT MTDH RBSN
Entrez ID		2593	53917
HPRD ID		03142	06697
Ensembl ID		ENSG00000130005	ENSG00000169228
Uniprot IDs		Q14353 V9HWB2	Q969Q5
PDB IDs		3ORH
Enriched GO Terms of Interacting Partners?		Shelterin Complex Nuclear Telomere Cap Complex G-rich Strand Telomeric DNA Binding Telomere Capping Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Telomeric DNA Binding Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance Positive Regulation Of Telomere Maintenance Negative Regulation Of Chromosome Organization Telomeric D-loop Disassembly DNA Biosynthetic Process Telomeric Loop Disassembly Telomere Maintenance Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Telomere Organization Negative Regulation Of DNA Metabolic Process Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Chromosome, Telomeric Region Negative Regulation Of DNA Biosynthetic Process Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Chromosome Organization Negative Regulation Of Proteasomal Protein Catabolic Process Reproductive Process Medium-term Memory Cellular Response To Prolactin Negative Regulation Of Establishment Of Protein Localization To Telomere Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of DNA Metabolic Process Chromosome Positive Regulation Of Shelterin Complex Assembly Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Chromosome Organization Nucleus Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Nucleobase-containing Compound Biosynthetic Process Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Regulation Of DNA Biosynthetic Process Positive Regulation Of Telomeric Loop Disassembly Negative Regulation Of DNA Recombination At Telomere
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