GAMT

Description		guanidinoacetate N-methyltransferase
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol
	Molecular Function	Protein Binding Methyltransferase Activity Transferase Activity Guanidinoacetate N-methyltransferase Activity
	Biological Process	Creatine Metabolic Process Creatine Biosynthetic Process Muscle Contraction Spermatogenesis Animal Organ Morphogenesis Methylation Regulation Of Multicellular Organism Growth
Pathways		Creatine metabolism Transcriptional Regulation by MECP2
Drugs		Creatine Guanidine S-adenosyl-L-homocysteine Glycocyamine Phosphocreatine
Diseases		Guanidinoacetate methyltransferase (GAMT) deficiency Creatine deficiency syndrome, including: Arginine:glycine amidinotransferase deficiency (AGAT deficiency); Guanidinoacetate methyltransferase deficiency (GAMT deficiency); X-linked creatine deficiency syndrome (XL-CDS)
GWAS
Novel Interacting Genes		10 novel interacting genes: CSNK2B FOS GPX4 LCOR POT1 RAB24 RSPH1 TERF1 TERF2IP TRIM39
Interacting Genes		10 interacting genes: CSNK2B FOS GPX4 LCOR POT1 RAB24 RSPH1 TERF1 TERF2IP TRIM39
Entrez ID		2593
HPRD ID		03142
Ensembl ID		ENSG00000130005
Uniprot IDs		Q14353 V9HWB2
PDB IDs		3ORH
Enriched GO Terms of Interacting Partners?		Shelterin Complex Nuclear Telomere Cap Complex G-rich Strand Telomeric DNA Binding Telomere Capping Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Telomeric DNA Binding Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance Positive Regulation Of Telomere Maintenance Negative Regulation Of Chromosome Organization Telomeric D-loop Disassembly DNA Biosynthetic Process Telomeric Loop Disassembly Telomere Maintenance Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Telomere Organization Negative Regulation Of DNA Metabolic Process Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Chromosome, Telomeric Region Negative Regulation Of DNA Biosynthetic Process Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Chromosome Organization Negative Regulation Of Proteasomal Protein Catabolic Process Reproductive Process Medium-term Memory Cellular Response To Prolactin Negative Regulation Of Establishment Of Protein Localization To Telomere Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of DNA Metabolic Process Chromosome Positive Regulation Of Shelterin Complex Assembly Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Chromosome Organization Nucleus Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Nucleobase-containing Compound Biosynthetic Process Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Regulation Of DNA Biosynthetic Process Positive Regulation Of Telomeric Loop Disassembly Negative Regulation Of DNA Recombination At Telomere
Tagcloud ?