GAMT and GPX4

		GAMT	GPX4
Description		guanidinoacetate N-methyltransferase	glutathione peroxidase 4
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Nucleus Nuclear Envelope Cytoplasm Mitochondrion Cytosol Protein-containing Complex Extracellular Exosome
	Molecular Function	Protein Binding Methyltransferase Activity Transferase Activity Guanidinoacetate N-methyltransferase Activity	Peroxidase Activity Glutathione Peroxidase Activity Protein Binding Selenium Binding Oxidoreductase Activity Identical Protein Binding Phospholipid-hydroperoxide Glutathione Peroxidase Activity
	Biological Process	Creatine Metabolic Process Creatine Biosynthetic Process Muscle Contraction Spermatogenesis Animal Organ Morphogenesis Methylation Regulation Of Multicellular Organism Growth	Chromatin Organization Lipid Metabolic Process Phospholipid Metabolic Process Apoptotic Process Response To Oxidative Stress Spermatogenesis Dendrite Development Arachidonate Metabolic Process Lipoxygenase Pathway Cerebellum Development Response To Estradiol Response To Lipopolysaccharide Multicellular Organism Growth Long-chain Fatty Acid Biosynthetic Process Protein Polymerization Cellular Oxidant Detoxification Negative Regulation Of Ferroptosis
Pathways		Creatine metabolism Transcriptional Regulation by MECP2	Synthesis of 5-eicosatetraenoic acids Synthesis of 12-eicosatetraenoic acid derivatives Synthesis of 15-eicosatetraenoic acid derivatives
Drugs		Creatine Guanidine S-adenosyl-L-homocysteine Glycocyamine Phosphocreatine	Glutathione Glutathione Glutathione disulfide Benzoyl peroxide
Diseases		Guanidinoacetate methyltransferase (GAMT) deficiency Creatine deficiency syndrome, including: Arginine:glycine amidinotransferase deficiency (AGAT deficiency); Guanidinoacetate methyltransferase deficiency (GAMT deficiency); X-linked creatine deficiency syndrome (XL-CDS)
GWAS			Advanced age-related macular degeneration ( 26691988) Asthma (childhood onset) ( 31036433) Basal cell carcinoma ( 31174203) Crohn's disease ( 23128233 21102463 28067908) Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) hemolysis of donated blood (oxidative) ( 34014839) Inflammatory bowel disease ( 28067908) Keratinocyte cancer (MTAG) ( 31174203) Liver enzyme levels (alkaline phosphatase) ( 33972514) Nasal polyps ( 30643255) Neutrophil percentage of granulocytes ( 27863252) Sum eosinophil basophil counts ( 27863252) White blood cell count ( 32888494)
Interacting Genes		10 interacting genes: CSNK2B FOS GPX4 LCOR POT1 RAB24 RSPH1 TERF1 TERF2IP TRIM39	12 interacting genes: APBA3 EGR4 FUT5 GAMT GTF2F1 MAPK13 MATK PARK7 PRDX6 RNF31 SNRNP48 ZNF197
Entrez ID		2593	2879
HPRD ID		03142	11819
Ensembl ID		ENSG00000130005	ENSG00000167468
Uniprot IDs		Q14353 V9HWB2	P36969 Q6PI42
PDB IDs		3ORH	2GS3 2OBI 5H5Q 5H5R 5H5S 6ELW 6HKQ 6HN3 7L8K 7L8L 7L8M 7L8Q 7L8R 7U4I 7U4J 7U4K 7U4L 7U4M 7U4N 8Q8J 8Q8N
Enriched GO Terms of Interacting Partners?		Shelterin Complex Nuclear Telomere Cap Complex G-rich Strand Telomeric DNA Binding Telomere Capping Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Telomeric DNA Binding Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance Positive Regulation Of Telomere Maintenance Negative Regulation Of Chromosome Organization Telomeric D-loop Disassembly DNA Biosynthetic Process Telomeric Loop Disassembly Telomere Maintenance Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Telomere Organization Negative Regulation Of DNA Metabolic Process Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Chromosome, Telomeric Region Negative Regulation Of DNA Biosynthetic Process Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Chromosome Organization Negative Regulation Of Proteasomal Protein Catabolic Process Reproductive Process Medium-term Memory Cellular Response To Prolactin Negative Regulation Of Establishment Of Protein Localization To Telomere Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of DNA Metabolic Process Chromosome Positive Regulation Of Shelterin Complex Assembly Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Chromosome Organization Nucleus Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Nucleobase-containing Compound Biosynthetic Process Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Regulation Of DNA Biosynthetic Process Positive Regulation Of Telomeric Loop Disassembly Negative Regulation Of DNA Recombination At Telomere	Peroxiredoxin Activity Transferase Activity Guanidinoacetate N-methyltransferase Activity Hydrogen Peroxide Metabolic Process Glyoxal Catabolic Process L-dopa Decarboxylase Activator Activity Guanine Deglycation Protein Deglycase Activity Glyoxalase (glycolic Acid-forming) Activity Glycolate Biosynthetic Process Guanine Deglycation, Methylglyoxal Removal Guanine Deglycation, Glyoxal Removal Detoxification Of Mercury Ion Negative Regulation Of Death-inducing Signaling Complex Assembly Cellular Response To Glyoxal Glyoxal Metabolic Process Positive Regulation Of L-dopa Biosynthetic Process Tyrosine 3-monooxygenase Activator Activity 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase Activity Creatine Biosynthetic Process TFIIF-class Transcription Factor Complex Binding Transcription Factor TFIIF Complex Cellular Response To Sorbitol Cellular Response To Hydrogen Peroxide Cellular Oxidant Detoxification Negative Regulation Of Protein K48-linked Deubiquitination Detection Of Oxidative Stress Negative Regulation Of Nitrosative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Dopamine Biosynthetic Process Creatine Metabolic Process Cellular Response To Anisomycin Response To Oxidative Stress Reactive Oxygen Species Metabolic Process Negative Regulation Of TRAIL-activated Apoptotic Signaling Pathway Superoxide Dismutase Copper Chaperone Activity Positive Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Glycolate Metabolic Process Detoxification Of Hydrogen Peroxide Regulation Of Protein K48-linked Deubiquitination Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of TRAIL Production Mercury Ion Binding Linear Polyubiquitin Binding Response To Hydrogen Peroxide Response To Anisomycin Cellular Response To Reactive Oxygen Species Response To Sorbitol Cellular Detoxification Cellular Detoxification Of Methylglyoxal Methylglyoxal Catabolic Process To Lactate
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