NELFB and DENR

Number of citations of the paper that reports this interaction (PubMedID 20195357)
57

Data Source:
BioGRID (pull down)

		NELFB	DENR
Description		negative elongation factor complex member B	density regulated re-initiation and release factor
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm NELF Complex	Cytoplasm
	Molecular Function	RNA Binding Protein Binding	Translation Initiation Factor Activity Protein Binding
	Biological Process	Cell Population Proliferation Negative Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Stem Cell Differentiation Negative Regulation Of Stem Cell Differentiation	Formation Of Translation Preinitiation Complex Cytoplasmic Translational Initiation Translation Reinitiation Translation Translational Initiation Ribosome Disassembly IRES-dependent Viral Translational Initiation
Pathways		Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA Polymerase II Transcription Elongation NTRK3 as a dependence receptor
Drugs
Diseases
GWAS			Apolipoprotein A1 levels ( 32203549) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Thrombin-activatable fibrinolysis inhibitor levels ( 29378355)
Interacting Genes		18 interacting genes: BRCA1 CEBPA CEBPE DENR ESR1 EXOSC2 FOS HSPA9 JUN KHDRBS3 MAPK6 MGST1 NELFE NTRK3 RAD51 TPRX1 TUBB4B WDR5	4 interacting genes: MCTS1 NELFB SCARB1 UBC
Entrez ID		25920	8562
HPRD ID		10845	05182
Ensembl ID		ENSG00000188986	ENSG00000139726
Uniprot IDs		Q8WX92	O43583
PDB IDs		6GML 7PKS 7YCX 8JJ6 8RBX 8UHA 8UHD 8UHG 8UI0 8W8E 9J0N 9J0O 9J0P	5ONS 5VYC 6MS4 6VPQ 6VPR
Enriched GO Terms of Interacting Partners?		Integrated Stress Response Signaling Chromatin Binding Chromatin Myeloid Cell Differentiation Response To Lipid RNA Polymerase II Transcription Regulator Complex Nucleoplasm Nuclear Ubiquitin Ligase Complex Myeloid Leukocyte Differentiation Transcription Factor AP-1 Complex Cellular Response To Oxygen-containing Compound Enzyme Binding DNA-templated Transcription DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Response To Steroid Hormone Regulation Of MiRNA Transcription Nucleic Acid Metabolic Process Nucleus Protein-containing Complex Cellular Response To Lipid Lateral Element Transcription Regulator Complex Regulation Of MiRNA Metabolic Process Transcription Cis-regulatory Region Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Cellular Response To Tumor Necrosis Factor Response To Alcohol Response To Corticosterone Positive Regulation Of Transcription By RNA Polymerase II Identical Protein Binding Response To Xenobiotic Stimulus Positive Regulation Of RNA Metabolic Process Response To Tumor Necrosis Factor Regulation Of DNA Damage Checkpoint Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II RNA Metabolic Process Mononuclear Cell Differentiation Response To Glucocorticoid Response To Hormone Double-stranded DNA Binding Response To Muscle Stretch SMAD Protein Signal Transduction R-SMAD Binding Granulocyte Differentiation Nuclear Chromosome Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process	Endocytic Vesicle Membrane Positive Regulation Of Sphingolipid Mediated Signaling Pathway High-density Lipoprotein Particle Receptor Activity High Density Lipoprotein Particle Mediated Signaling Regulation Of Sphingolipid Mediated Signaling Pathway Lipopolysaccharide Transport Cholesterol Catabolic Process Recognition Of Apoptotic Cell Lipopolysaccharide Immune Receptor Activity Positive Regulation Of Cholesterol Storage Positive Regulation Of Nitric Oxide Mediated Signal Transduction Cholesterol Import Detection Of Lipopolysaccharide Regulation Of Phospholipid Catabolic Process Apolipoprotein A-I Binding High-density Lipoprotein Particle Clearance Regulation Of Phosphatidylcholine Catabolic Process NELF Complex Translation Reinitiation Formation Of Translation Preinitiation Complex Detection Of Molecule Of Bacterial Origin Regulation Of Phosphatidylcholine Metabolic Process Positive Regulation Of Triglyceride Biosynthetic Process Regulation Of Nitric Oxide Mediated Signal Transduction High-density Lipoprotein Particle Binding Intestinal Lipid Absorption Phagocytosis, Recognition RNA Binding RNA Cap Binding IRES-dependent Viral Translational Initiation Adhesion Of Symbiont To Host 1-phosphatidylinositol Binding Low-density Lipoprotein Particle Binding Apolipoprotein Binding Low-density Lipoprotein Particle Clearance Reverse Cholesterol Transport Vitamin Transmembrane Transport Protein Tag Activity Regulation Of Triglyceride Biosynthetic Process High-density Lipoprotein Particle Remodeling Ribosomal Small Subunit Binding Positive Regulation Of Lipid Storage Positive Regulation Of Triglyceride Metabolic Process Steroid Catabolic Process Negative Regulation Of Transcription Elongation By RNA Polymerase II Scavenger Receptor Activity Negative Regulation Of Stem Cell Differentiation Negative Regulation Of DNA-templated Transcription, Elongation Plasma Lipoprotein Particle Clearance Intestinal Absorption
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