GALT and CCL19

		GALT	CCL19
Description		galactose-1-phosphate uridylyltransferase	C-C motif chemokine ligand 19
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GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytosol	Extracellular Region Extracellular Space
	Molecular Function	Protein Binding UDP-glucose:hexose-1-phosphate Uridylyltransferase Activity Zinc Ion Binding Transferase Activity Nucleotidyltransferase Activity Metal Ion Binding	Cytokine Activity Protein Binding Chemokine Activity CCR7 Chemokine Receptor Binding CCR10 Chemokine Receptor Binding Chemokine Receptor Binding CCR Chemokine Receptor Binding
	Biological Process	UDP-alpha-D-glucose Metabolic Process Galactose Metabolic Process Phosphate-containing Compound Metabolic Process Organophosphate Metabolic Process Galactose Catabolic Process Via UDP-galactose, Leloir Pathway Carbohydrate Derivative Metabolic Process	Establishment Of T Cell Polarity Immunological Synapse Formation Dendritic Cell Chemotaxis Myeloid Dendritic Cell Chemotaxis Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Intracellular Calcium Ion Homeostasis Chemotaxis Inflammatory Response Immune Response Cell Communication Response To Virus Positive Regulation Of Glycoprotein Biosynthetic Process Positive Regulation Of Cell Migration T Cell Costimulation Killing Of Cells Of Another Organism Regulation Of Cdc42 Protein Signal Transduction Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Rac Protein Signal Transduction CCL19-activated CCR7 Signaling Pathway Positive Regulation Of T Cell Proliferation Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of Endocytosis Positive Regulation Of JNK Cascade Eosinophil Chemotaxis Positive Regulation Of Receptor-mediated Endocytosis Cell Maturation Positive Regulation Of Chemotaxis Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell Projection Assembly Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Prostaglandin E Stimulus Response To Nitric Oxide Positive Regulation Of Neutrophil Chemotaxis Mature Conventional Dendritic Cell Differentiation Cellular Response To Virus Positive Regulation Of Phospholipase C/protein Kinase C Signal Transduction Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Cell Motility Positive Regulation Of Dendritic Cell Dendrite Assembly Negative Regulation Of Dendritic Cell Apoptotic Process
Pathways		Defective GALT can cause GALCT Galactose catabolism	Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling
Drugs
Diseases		Galactosemia
GWAS			Metabolite levels ( 23823483) Rheumatoid arthritis ( 24390342 30423114)
Interacting Genes		8 interacting genes: CCL19 CCL21 GRPEL1 KRTAP6-2 NQO1 TNK2 TRIP13 VAC14	18 interacting genes: ACKR2 ACKR4 ATP6V0B B4GALT1 CCL22 CCR10 CCR7 CNTFR CXCL13 DCTN3 FZD7 GALT MEOX2 PAX5 PF4V1 PPM1E RPS4X TLN1
Entrez ID		2592	6363
HPRD ID		06106	03750
Ensembl ID		ENSG00000213930	ENSG00000172724
Uniprot IDs		A0A0S2Z3Y7 B2RAT6 P07902	Q6IBD6 Q99731
PDB IDs		5IN3 6GQD	2MP1 7STA
Enriched GO Terms of Interacting Partners?		Regulation Of Receptor-mediated Endocytosis CCR7 Chemokine Receptor Binding Regulation Of Dendritic Cell Dendrite Assembly Positive Regulation Of Phospholipase C/protein Kinase C Signal Transduction Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Establishment Of T Cell Polarity Negative Regulation Of Dendritic Cell Apoptotic Process Regulation Of Endocytosis Chemokine Receptor Binding Immunological Synapse Formation Identical Protein Binding Dendritic Cell Chemotaxis Positive Regulation Of Glycoprotein Biosynthetic Process Cellular Response To Prostaglandin E Stimulus Eosinophil Chemotaxis Positive Regulation Of Glycoprotein Metabolic Process Cell Maturation Eosinophil Migration Regulation Of Antigen Processing And Presentation Dendritic Cell Migration Positive Regulation Of Neutrophil Chemotaxis Response To Prostaglandin E Positive Regulation Of Granulocyte Chemotaxis Cellular Response To Prostaglandin Stimulus CCR Chemokine Receptor Binding Regulation Of Vesicle-mediated Transport Positive Regulation Of Neutrophil Migration Developmental Maturation Regulation Of Neutrophil Chemotaxis Regulation Of Glycoprotein Biosynthetic Process Regulation Of Neutrophil Migration T Cell Costimulation Chemokine Activity Regulation Of Granulocyte Chemotaxis Positive Regulation Of Receptor-mediated Endocytosis Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Leukocyte Apoptotic Process Cell-cell Recognition Negative Regulation Of Sequestering Of Calcium Ion NADH Dehydrogenase (quinone) (non-electrogenic) Activity Positive Regulation Of Dendritic Cell Dendrite Assembly Dendritic Cell Dendrite Assembly Negative Regulation Of Dendritic Cell Dendrite Assembly PAS Complex Granulocyte Chemotaxis Chemokine-mediated Signaling Pathway Calcium Ion Transmembrane Import Into Cytosol Granulocyte Migration Establishment Of Cell Polarity Positive Regulation Of Leukocyte Chemotaxis	Chemokine-mediated Signaling Pathway Cell Chemotaxis C-C Chemokine Receptor Activity Chemokine Receptor Activity Chemotaxis Locomotion Cytokine-mediated Signaling Pathway Myeloid Leukocyte Migration Positive Regulation Of Cytosolic Calcium Ion Concentration External Side Of Plasma Membrane Cell Migration C-C Chemokine Binding Leukocyte Migration Immune System Process Cell Motility G Protein-coupled Receptor Signaling Pathway Leukocyte Chemotaxis Inflammatory Response Chemokine Activity Calcium-mediated Signaling G Protein-coupled Receptor Activity Galactose Metabolic Process Positive Regulation Of Epithelial Cell Proliferation Involved In Wound Healing Granulocyte Chemotaxis Cell Surface Receptor Signaling Pathway CXCR Chemokine Receptor Binding Cellular Response To Lipid Granulocyte Migration Immune Response Mononuclear Cell Migration Response To Lipopolysaccharide Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Response To Molecule Of Bacterial Origin Antimicrobial Humoral Response C-C Motif Chemokine 19 Receptor Activity Chemokine (C-C Motif) Ligand 19 Binding Positive Regulation Of Glycoprotein Biosynthetic Process Involved In Immunological Synapse Formation Chemokine (C-C Motif) Ligand 21 Binding C-C Motif Chemokine 21 Receptor Activity UDP-glucose:hexose-1-phosphate Uridylyltransferase Activity Positive Regulation Of Circulating Fibrinogen Levels Cellular Response To Molecule Of Bacterial Origin Cellular Response To Lipopolysaccharide Negative Regulation Of Ectodermal Cell Fate Specification CXCR5 Chemokine Receptor Binding Lymphocyte Chemotaxis Across High Endothelial Venule Endothelial Cell Chemotaxis To Fibroblast Growth Factor Response To Lipid Regulation Of Humoral Immune Response Signal Transduction
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