CCL19 and B4GALT1

		CCL19	B4GALT1
Description		C-C motif chemokine ligand 19	beta-1,4-galactosyltransferase 1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Golgi Trans Cisterna Golgi Membrane Extracellular Region Extracellular Space Golgi Apparatus Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Basolateral Plasma Membrane Desmosome Filopodium Secretory Granule Membrane Brush Border Membrane Golgi Cisterna Membrane Protein-containing Complex Azurophil Granule Membrane Cell Projection Extracellular Exosome
	Molecular Function	Cytokine Activity Protein Binding Chemokine Activity CCR7 Chemokine Receptor Binding CCR10 Chemokine Receptor Binding Chemokine Receptor Binding CCR Chemokine Receptor Binding	Beta-N-acetylglucosaminylglycopeptide Beta-1,4-galactosyltransferase Activity N-acetyllactosamine Synthase Activity Lactose Synthase Activity Galactosyltransferase Activity Transferase Activity Glycosyltransferase Activity Manganese Ion Binding UDP-galactosyltransferase Activity Identical Protein Binding Alpha-tubulin Binding Metal Ion Binding Beta-tubulin Binding
	Biological Process	Establishment Of T Cell Polarity Immunological Synapse Formation Dendritic Cell Chemotaxis Myeloid Dendritic Cell Chemotaxis Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Intracellular Calcium Ion Homeostasis Chemotaxis Inflammatory Response Immune Response Cell Communication Response To Virus Positive Regulation Of Glycoprotein Biosynthetic Process Positive Regulation Of Cell Migration T Cell Costimulation Killing Of Cells Of Another Organism Regulation Of Cdc42 Protein Signal Transduction Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Rac Protein Signal Transduction CCL19-activated CCR7 Signaling Pathway Positive Regulation Of T Cell Proliferation Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of Endocytosis Positive Regulation Of JNK Cascade Eosinophil Chemotaxis Positive Regulation Of Receptor-mediated Endocytosis Cell Maturation Positive Regulation Of Chemotaxis Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell Projection Assembly Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Prostaglandin E Stimulus Response To Nitric Oxide Positive Regulation Of Neutrophil Chemotaxis Mature Conventional Dendritic Cell Differentiation Cellular Response To Virus Positive Regulation Of Phospholipase C/protein Kinase C Signal Transduction Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Cell Motility Positive Regulation Of Dendritic Cell Dendrite Assembly Negative Regulation Of Dendritic Cell Apoptotic Process	Epithelial Cell Development Acute Inflammatory Response Carbohydrate Metabolic Process Lactose Biosynthetic Process Galactose Metabolic Process Protein Glycosylation Protein N-linked Glycosylation Lipid Metabolic Process Cell Adhesion Binding Of Sperm To Zona Pellucida Penetration Of Zona Pellucida Cell Population Proliferation Glycoprotein Biosynthetic Process Oligosaccharide Biosynthetic Process Extracellular Matrix Organization Wound Healing Positive Regulation Of Apoptotic Process Development Of Secondary Sexual Characteristics Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Regulation Of Acrosome Reaction Positive Regulation Of Epithelial Cell Proliferation Involved In Wound Healing Angiogenesis Involved In Wound Healing Positive Regulation Of Circulating Fibrinogen Levels Macrophage Migration
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling	Pre-NOTCH Processing in Golgi Keratan sulfate biosynthesis Interaction With Cumulus Cells And The Zona Pellucida Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective B4GALT1 causes CDG-2d Lactose synthesis Neutrophil degranulation N-Glycan antennae elongation
Drugs			N-Acetylglucosamine 6-Aminohexyl-uridine-C1,5'-diphosphate 4)-N-acetyl-beta-D-glucosamine Galactose-uridine-5'-diphosphate Uridine monophosphate 2-(N-morpholino)ethanesulfonic acid
Diseases			Congenital disorders of glycosylation (CDG) type II
GWAS		Metabolite levels ( 23823483) Rheumatoid arthritis ( 24390342 30423114)	Aspartate aminotransferase levels ( 33547301 33339817 29403010) Blood protein levels ( 30072576) Hematocrit ( 32888494) Hemoglobin ( 32888494) IgG fucosylation phenotypes (multivariate analysis) ( 28878392) IgG galactosylation phenotypes (multivariate analysis) ( 28878392) IgG glycosylation ( 23382691) IgG N-glycosylation phenotypes (multivariate analysis) ( 28878392 32128391) Influenza A (H1N1) infection ( 26379185) Iron status biomarkers (ferritin levels) ( 33536631) Mild influenza (H1N1) infection ( 26379185) N-glycan levels ( 31163085) Red blood cell count ( 32888494) Serum uric acid levels ( 30993211) Severe influenza A (H1N1) infection ( 26379185) Urate levels ( 31578528 31985003 23263486)
Interacting Genes		18 interacting genes: ACKR2 ACKR4 ATP6V0B B4GALT1 CCL22 CCR10 CCR7 CNTFR CXCL13 DCTN3 FZD7 GALT MEOX2 PAX5 PF4V1 PPM1E RPS4X TLN1	10 interacting genes: CCL19 CDK11A EGFR LALBA OR10G4 SNCA TFRC TUBA1A TUBA4A TUBB
Entrez ID		6363	2683
HPRD ID		03750	00659
Ensembl ID		ENSG00000172724	ENSG00000086062
Uniprot IDs		Q6IBD6 Q99731	B7ZAH9 P15291 Q86XA6 W6MEN3
PDB IDs		2MP1 7STA	2AE7 2AEC 2AES 2AGD 2AH9 2FY7 2FYA 2FYB 3EE5 4EE3 4EE4 4EE5 4EEA 4EEG 4EEM 4EEO 4L41 6FWT 6FWU
Enriched GO Terms of Interacting Partners?		Chemokine-mediated Signaling Pathway Cell Chemotaxis C-C Chemokine Receptor Activity Chemokine Receptor Activity Chemotaxis Locomotion Cytokine-mediated Signaling Pathway Myeloid Leukocyte Migration Positive Regulation Of Cytosolic Calcium Ion Concentration External Side Of Plasma Membrane Cell Migration C-C Chemokine Binding Leukocyte Migration Immune System Process Cell Motility G Protein-coupled Receptor Signaling Pathway Leukocyte Chemotaxis Inflammatory Response Chemokine Activity Calcium-mediated Signaling G Protein-coupled Receptor Activity Galactose Metabolic Process Positive Regulation Of Epithelial Cell Proliferation Involved In Wound Healing Granulocyte Chemotaxis Cell Surface Receptor Signaling Pathway CXCR Chemokine Receptor Binding Cellular Response To Lipid Granulocyte Migration Immune Response Mononuclear Cell Migration Response To Lipopolysaccharide Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Response To Molecule Of Bacterial Origin Antimicrobial Humoral Response C-C Motif Chemokine 19 Receptor Activity Chemokine (C-C Motif) Ligand 19 Binding Positive Regulation Of Glycoprotein Biosynthetic Process Involved In Immunological Synapse Formation Chemokine (C-C Motif) Ligand 21 Binding C-C Motif Chemokine 21 Receptor Activity UDP-glucose:hexose-1-phosphate Uridylyltransferase Activity Positive Regulation Of Circulating Fibrinogen Levels Cellular Response To Molecule Of Bacterial Origin Cellular Response To Lipopolysaccharide Negative Regulation Of Ectodermal Cell Fate Specification CXCR5 Chemokine Receptor Binding Lymphocyte Chemotaxis Across High Endothelial Venule Endothelial Cell Chemotaxis To Fibroblast Growth Factor Response To Lipid Regulation Of Humoral Immune Response Signal Transduction	Mitotic Cell Cycle Structural Constituent Of Cytoskeleton Extracellular Region Regulation Of Cellular Component Organization Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Clathrin-coated Endocytic Vesicle Membrane Positive Regulation Of Protein Localization To Cell Periphery Response To Lipid Protein-containing Complex Virus Receptor Activity Negative Regulation Of Apoptotic Process Shc-EGFR Complex Extracellular Space Multivesicular Body, Internal Vesicle Lumen Lactose Biosynthetic Process CCR7 Chemokine Receptor Binding CCL19-activated CCR7 Signaling Pathway Positive Regulation Of Dendritic Cell Dendrite Assembly Response To Desipramine Response To Iron Ion Adult Locomotory Behavior Negative Regulation Of Norepinephrine Uptake Response To Copper Ion Response To Metal Ion Regulation Of Synapse Organization Phospholipase D Inhibitor Activity Regulation Of Norepinephrine Uptake Positive Regulation Of SNARE Complex Assembly Receptor Internalization Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Hsp70 Protein Binding Transferrin Receptor Activity Protein-containing Complex Binding Microtubule Microtubule Cytoskeleton GTP Binding Cytoplasmic Ribonucleoprotein Granule Apoptotic Process Negative Regulation Of Programmed Cell Death Nucleotide Binding Enzyme Binding Regulation Of Cell Growth Positive Regulation Of Protein Kinase C Signaling Epidermal Growth Factor Receptor Activity Cell Death Programmed Cell Death Lactose Synthase Activity
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