DPCD and ACTR1A

		DPCD	ACTR1A
Description		deleted in primary ciliary dyskinesia homolog (mouse)	actin related protein 1A
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus	Cytoplasm Centrosome Microtubule Organizing Center Cytosol Cytoskeleton Dynactin Complex Microtubule Associated Complex Cell Cortex Extracellular Exosome
	Molecular Function	Protein Binding	Nucleotide Binding Protein Binding ATP Binding
	Biological Process	Epithelial Cilium Movement Involved In Extracellular Fluid Movement Spermatogenesis Determination Of Left/right Symmetry Ventricular System Development Lateral Ventricle Development Third Ventricle Development Flagellated Sperm Motility Establishment Of Localization In Cell Left/right Pattern Formation	Vesicle-mediated Transport
Pathways			MHC class II antigen presentation Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic AURKA Activation by TPX2
Drugs
Diseases
GWAS		Mean corpuscular volume ( 32888494)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (MOSTest) ( 32665545) Hip circumference adjusted for BMI ( 34021172) Insomnia symptoms (never/rarely vs. sometimes/usually) ( 30804566) Insomnia symptoms (never/rarely vs. usually) ( 30804566) Prostate cancer ( 23535732) Refractive error ( 32231278) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		13 interacting genes: ACTR1A APP BTRC CNNM2 CUEDC2 GUCA2B HACD3 MNDA NDUFS7 NOLC1 PPRC1 RUVBL2 WBP1L	9 interacting genes: CEBPA CNNM2 DCTN1 DCTN4 DPCD NUMA1 SNCA SPTBN1 SPTBN2
Entrez ID		25911	10121
HPRD ID		13247	05507
Ensembl ID		ENSG00000166171	ENSG00000138107
Uniprot IDs		Q5JQQ4 Q9BVM2	A0A384NQ21 B4DXP9 P61163
PDB IDs
Enriched GO Terms of Interacting Partners?			Cell Cortex Cell Cortex Region Regulation Of Supramolecular Fiber Organization Regulation Of Protein-containing Complex Assembly Regulation Of Cytoskeleton Organization Regulation Of Microtubule Polymerization Positive Regulation Of Protein Localization To Cell Periphery Spectrin Regulation Of Microtubule Polymerization Or Depolymerization Protein-containing Complex Neuronal Cell Body Cytoskeleton Phospholipid Binding Negative Regulation Of Protein-containing Complex Assembly Spindle Pole Regulation Of Protein Localization To Cell Periphery Dynein Complex Binding Negative Regulation Of Supramolecular Fiber Organization Negative Regulation Of Cytoskeleton Organization Regulation Of Microtubule Cytoskeleton Organization Microtubule Plus-end Positive Regulation Of Microtubule Polymerization Positive Regulation Of Protein-containing Complex Assembly Actin Filament Capping Regulation Of Organelle Organization Establishment Of Mitotic Spindle Orientation Protein Domain Specific Binding Negative Regulation Of Actin Filament Depolymerization Establishment Of Mitotic Spindle Localization Regulation Of Mitotic Spindle Organization Establishment Of Spindle Orientation Tau Protein Binding Microtubule Binding Synapse Organization Regulation Of Microtubule-based Process Negative Regulation Of Actin Filament Polymerization Establishment Of Organelle Localization Regulation Of Actin Filament Depolymerization RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Macrophage Activation Establishment Of Spindle Localization Tubulin Binding Spindle Localization Cortical Microtubule Anastral Spindle Assembly Cytoplasmic Microtubule Bundle Positive Regulation Of Protein Localization To Spindle Pole Body Positive Regulation Of Mitotic Spindle Elongation Response To Desipramine Negative Regulation Of Norepinephrine Uptake
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