KLK5 and DSG1

Number of citations of the paper that reports this interaction (PubMedID 15140227)
0

Data Source:
HPRD (in vitro)

		KLK5	DSG1
Description		kallikrein related peptidase 5	desmoglein 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol Secretory Granule Epidermal Lamellar Body	Cornified Envelope Nucleus Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Cytoplasmic Side Of Plasma Membrane Membrane Apical Plasma Membrane Lateral Plasma Membrane Desmosome Anchoring Junction Ficolin-1-rich Granule Membrane
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity	Calcium Ion Binding Protein Binding Toxic Substance Binding Gamma-catenin Binding Metal Ion Binding
	Biological Process	Positive Regulation Of Antibacterial Peptide Production Proteolysis Epidermis Development Extracellular Matrix Disassembly Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Protein Maturation Cornification Amelogenesis	Cell-cell Junction Assembly Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Response To Progesterone Protein Stabilization Maternal Process Involved In Female Pregnancy Cell-cell Adhesion
Pathways		Formation of the cornified envelope Formation of the cornified envelope Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	Apoptotic cleavage of cell adhesion proteins Neutrophil degranulation Keratinization Formation of the cornified envelope RND3 GTPase cycle RND2 GTPase cycle
Drugs
Diseases			Striate palmoplantar keratoderma
GWAS			Eosinophilic esophagitis (pediatric) ( 20208534) perceptual and visual search speed (trail making test A) (age interaction) ( 24629169) Yeast infection ( 28928442)
Interacting Genes		12 interacting genes: AURKA BAG4 CASP8 DSG1 ERBB2 ESR1 IGF1R MANBAL NOTCH2 SERPINA1 TGFB1 TSG101	8 interacting genes: CDC42 DSC1 DSC2 JUP KLK5 PKP1 PKP2 PKP3
Entrez ID		25818	1828
HPRD ID		05732	00515
Ensembl ID		ENSG00000167754	ENSG00000134760
Uniprot IDs		Q9Y337	Q02413
PDB IDs		2PSX 2PSY 6QFE 7U5B
Enriched GO Terms of Interacting Partners?		Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Intracellular Signal Transduction Positive Regulation Of Myeloid Leukocyte Differentiation Negative Regulation Of Apoptotic Process Response To Wounding Regulation Of MiRNA Transcription Regulation Of Signal Transduction Regulation Of MiRNA Metabolic Process Positive Regulation Of Macrophage Differentiation Response To Estradiol Regulation Of Cell Communication Positive Regulation Of Intracellular Signal Transduction Ubiquitin Protein Ligase Binding Positive Regulation Of Myeloid Cell Differentiation Regulation Of Signaling Plasma Membrane Branch Elongation Of An Epithelium Liver Development Positive Regulation Of Fibroblast Migration Axis Elongation Protein-containing Complex Binding Branching Involved In Mammary Gland Duct Morphogenesis Regulation Of Myeloid Leukocyte Differentiation Developmental Growth Developmental Growth Involved In Morphogenesis Myeloid Dendritic Cell Differentiation Positive Regulation Of Smooth Muscle Cell Differentiation Myeloid Leukocyte Differentiation Regulation Of Macrophage Differentiation Positive Regulation Of Cell Development Regulation Of Cell Development Regulation Of Hemopoiesis Animal Organ Development Negative Regulation Of MiRNA Transcription Myeloid Dendritic Cell Activation Gland Morphogenesis Liver Regeneration Lymphocyte Activation Positive Regulation Of MAPK Cascade Plasma Membrane Bounded Cell Projection Organization Maternal Process Involved In Female Pregnancy Epithelial Cell Proliferation Positive Regulation Of Cell Population Proliferation Response To Progesterone Positive Regulation Of Leukocyte Differentiation Receptor Complex Positive Regulation Of Epithelial Cell Proliferation Dendritic Cell Differentiation	Desmosome Desmosome Organization Cornified Envelope Desmosome Assembly Cell-cell Junction Organization Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Cardiac Muscle Cell-cardiac Muscle Cell Adhesion Anchoring Junction Adherens Junction Alpha-catenin Binding Cell Junction Organization Cell-cell Adhesion Regulation Of Ventricular Cardiac Muscle Cell Action Potential Cell Junction Assembly Cell-cell Junction Assembly Desmosome Maintenance Regulation Of Cardiac Muscle Cell Action Potential Regulation Of Cardiac Muscle Cell Contraction Cell Adhesion Heterotypic Cell-cell Adhesion Regulation Of Heart Rate By Cardiac Conduction Intercalated Disc Cardiac Conduction Cell Junction Cell-cell Junction Regulation Of Action Potential Homotypic Cell-cell Adhesion Intermediate Filament Binding Intermediate Filament Bundle Assembly Regulation Of Cardiac Muscle Contraction Cadherin Binding Regulation Of Striated Muscle Contraction Regulation Of Cell Adhesion Regulation Of Heart Rate Regulation Of Actin Filament-based Process Epithelial Cell-cell Adhesion Cell-cell Junction Maintenance Intermediate Filament Positive Regulation Of Cell Adhesion Regulation Of Muscle Contraction Protein Localization To Plasma Membrane Regulation Of Heart Contraction Regulation Of Cell-substrate Adhesion Protein Localization To Cell Periphery Regulation Of Muscle System Process Regulation Of Blood Circulation Cell Junction Maintenance Ficolin-1-rich Granule Membrane Protein Localization To Membrane
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