DSG1 and PKP3

Number of citations of the paper that reports this interaction (PubMedID 12707304)
49

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, two hybrid)

		DSG1	PKP3
Description		desmoglein 1	plakophilin 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Nucleus Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Cytoplasmic Side Of Plasma Membrane Membrane Apical Plasma Membrane Lateral Plasma Membrane Desmosome Anchoring Junction Ficolin-1-rich Granule Membrane	Cornified Envelope Nucleus Nucleoplasm Cytoplasm Plasma Membrane Cell-cell Junction Adherens Junction Membrane Cell Junction Desmosome Anchoring Junction
	Molecular Function	Calcium Ion Binding Protein Binding Toxic Substance Binding Gamma-catenin Binding Metal Ion Binding	RNA Binding Protein Binding Enzyme Binding Alpha-catenin Binding Cadherin Binding Cell Adhesion Molecule Binding Cadherin Binding Involved In Cell-cell Adhesion
	Biological Process	Cell-cell Junction Assembly Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Response To Progesterone Protein Stabilization Maternal Process Involved In Female Pregnancy Cell-cell Adhesion	Desmosome Assembly Regulation Of Cytokine Production Involved In Immune Response Desmosome Organization Regulation Of Translation Cell Adhesion Regulation Of Gene Expression Epithelial Structure Maintenance Positive Regulation Of Cell-cell Adhesion Actin Cytoskeleton Organization Positive Regulation Of Cell Adhesion Regulation Of Hair Follicle Development Protein Localization To Plasma Membrane Epithelial Cell-cell Adhesion Cell-cell Adhesion Negative Regulation Of MRNA Catabolic Process Positive Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Protein Localization
Pathways		Apoptotic cleavage of cell adhesion proteins Neutrophil degranulation Keratinization Formation of the cornified envelope RND3 GTPase cycle RND2 GTPase cycle	Keratinization Formation of the cornified envelope
Drugs
Diseases		Striate palmoplantar keratoderma
GWAS		Eosinophilic esophagitis (pediatric) ( 20208534) perceptual and visual search speed (trail making test A) (age interaction) ( 24629169) Yeast infection ( 28928442)	Anorectal malformation ( 31136621) Lymphocyte count ( 32888494)
Interacting Genes		8 interacting genes: CDC42 DSC1 DSC2 JUP KLK5 PKP1 PKP2 PKP3	10 interacting genes: DSC1 DSC2 DSC3 DSG1 DSG2 DSG3 DSP IQUB JUP KRT18
Entrez ID		1828	11187
HPRD ID		00515	05711
Ensembl ID		ENSG00000134760	ENSG00000184363
Uniprot IDs		Q02413	Q9Y446
PDB IDs
Enriched GO Terms of Interacting Partners?		Desmosome Desmosome Organization Cornified Envelope Desmosome Assembly Cell-cell Junction Organization Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Cardiac Muscle Cell-cardiac Muscle Cell Adhesion Anchoring Junction Adherens Junction Alpha-catenin Binding Cell Junction Organization Cell-cell Adhesion Regulation Of Ventricular Cardiac Muscle Cell Action Potential Cell Junction Assembly Cell-cell Junction Assembly Desmosome Maintenance Regulation Of Cardiac Muscle Cell Action Potential Regulation Of Cardiac Muscle Cell Contraction Cell Adhesion Heterotypic Cell-cell Adhesion Regulation Of Heart Rate By Cardiac Conduction Intercalated Disc Cardiac Conduction Cell Junction Cell-cell Junction Regulation Of Action Potential Homotypic Cell-cell Adhesion Intermediate Filament Binding Intermediate Filament Bundle Assembly Regulation Of Cardiac Muscle Contraction Cadherin Binding Regulation Of Striated Muscle Contraction Regulation Of Cell Adhesion Regulation Of Heart Rate Regulation Of Actin Filament-based Process Epithelial Cell-cell Adhesion Cell-cell Junction Maintenance Intermediate Filament Positive Regulation Of Cell Adhesion Regulation Of Muscle Contraction Protein Localization To Plasma Membrane Regulation Of Heart Contraction Regulation Of Cell-substrate Adhesion Protein Localization To Cell Periphery Regulation Of Muscle System Process Regulation Of Blood Circulation Cell Junction Maintenance Ficolin-1-rich Granule Membrane Protein Localization To Membrane	Desmosome Cornified Envelope Desmosome Organization Cell-cell Adhesion Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Cardiac Muscle Cell-cardiac Muscle Cell Adhesion Anchoring Junction Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Regulation Of Ventricular Cardiac Muscle Cell Action Potential Cell-cell Junction Organization Cell-cell Junction Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Regulation Of Cardiac Muscle Cell Action Potential Regulation Of Cardiac Muscle Cell Contraction Heterotypic Cell-cell Adhesion Regulation Of Heart Rate By Cardiac Conduction Intercalated Disc Cardiac Conduction Regulation Of Action Potential Homotypic Cell-cell Adhesion Cell Junction Cell Junction Organization Regulation Of Cardiac Muscle Contraction Regulation Of Striated Muscle Contraction Regulation Of Heart Rate Calcium Ion Binding Positive Regulation Of Protein Localization To Cell-cell Junction Regulation Of Muscle Contraction Adherens Junction Regulation Of Heart Contraction Ficolin-1-rich Granule Membrane Regulation Of Protein Localization To Cell-cell Junction Desmosome Assembly Regulation Of Muscle System Process Regulation Of Blood Circulation Gamma-catenin Binding Extracellular Exosome Cell-cell Junction Assembly Epithelial Cell-cell Adhesion Regulation Of Actin Filament-based Process Regulation Of Membrane Potential Intermediate Filament Structural Molecule Activity Regulation Of Biological Quality Maternal Process Involved In Female Pregnancy Response To Progesterone Regulation Of System Process Regulation Of P38MAPK Cascade
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