SUN2 and ALS2

		SUN2	ALS2
Description		Sad1 and UNC84 domain containing 2	alsin Rho guanine nucleotide exchange factor ALS2
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Condensed Nuclear Chromosome Nucleus Nuclear Envelope Nuclear Inner Membrane Endosome Endosome Membrane Membrane Nuclear Membrane Meiotic Nuclear Membrane Microtubule Tethering Complex	Ruffle Nucleus Cytoplasm Early Endosome Centrosome Cytosol Postsynaptic Density Lamellipodium Dendrite Growth Cone Vesicle Protein-containing Complex Dendritic Spine Intracellular Membrane-bounded Organelle Glutamatergic Synapse
	Molecular Function	Protein Binding Lamin Binding Microtubule Binding Identical Protein Binding Protein-membrane Adaptor Activity Cytoskeleton-nuclear Membrane Anchor Activity	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Small GTPase Binding Identical Protein Binding Protein Homodimerization Activity Protein Serine/threonine Kinase Activator Activity
	Biological Process	Mitotic Spindle Organization Nuclear Migration Nucleokinesis Involved In Cell Motility In Cerebral Cortex Radial Glia Guided Migration Positive Regulation Of Cell Migration Nuclear Migration Along Microfilament Meiotic Cell Cycle Centrosome Localization Nuclear Matrix Anchoring At Nuclear Membrane	Behavioral Fear Response Receptor Recycling Response To Oxidative Stress Endosome Organization Lysosomal Transport Neuromuscular Junction Development Locomotory Behavior Intracellular Protein Localization Vesicle Organization Endosomal Transport Positive Regulation Of Rac Protein Signal Transduction Synaptic Transmission, Glutamatergic Positive Regulation Of GTPase Activity Positive Regulation Of Protein Kinase Activity Neuron Projection Morphogenesis Regulation Of Endosome Size Protein Homooligomerization Regulation Of Biological Quality Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels
Pathways		Meiotic synapsis	RAB GEFs exchange GTP for GDP on RABs RAC1 GTPase cycle
Drugs
Diseases			Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease Juvenile primary lateral sclerosis
GWAS		Heel bone mineral density ( 28869591) Prostate cancer ( 31562322) Resting heart rate ( 27798624) Sleep duration ( 30846698)	Perceived intensity of neohesperidin dihydrochalcone ( 31005972) Perceived intensity of sweet substances ( 31005972)
Interacting Genes		16 interacting genes: ALS2 APOBEC3C HGS MAFF MUC16 NRM PAEP PRPF6 PSMC2 RAB5B RASD2 RGS2 RPS20 SH3BP1 SRSF10 TXN2	4 interacting genes: IMPDH2 PPIL3 SUN2 YWHAB
Entrez ID		25777	57679
HPRD ID		15611	05893
Ensembl ID		ENSG00000100242	ENSG00000003393
Uniprot IDs		B0QY60 B0QY64 B4E2A6 Q9UH99	A0A7P0T8F3 A0A7P0Z4I4 A8K4R4 Q96Q42
PDB IDs		3UNP 4DXR 4DXS 4DXT 4FI9 6WMD 6WME 6WMF 6WMG
Enriched GO Terms of Interacting Partners?		Endosome Organization Spliceosomal Tri-snRNP Complex Assembly	IMP Dehydrogenase Activity Nuclear Migration Along Microfilament Nuclear Migration Along Microtubule Nuclear Matrix Organization Nucleokinesis Involved In Cell Motility In Cerebral Cortex Radial Glia Guided Migration Nuclear Matrix Anchoring At Nuclear Membrane GTP Biosynthetic Process 'de Novo' XMP Biosynthetic Process Phosphoserine Residue Binding Cytoskeleton-nuclear Membrane Anchor Activity Meiotic Nuclear Membrane Microtubule Tethering Complex
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