ALS2

Description		alsin Rho guanine nucleotide exchange factor ALS2
Image		No pdb structure
GO Annotations	Cellular Component	Ruffle Nucleus Cytoplasm Early Endosome Centrosome Cytosol Postsynaptic Density Lamellipodium Dendrite Growth Cone Vesicle Protein-containing Complex Dendritic Spine Intracellular Membrane-bounded Organelle Glutamatergic Synapse
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Small GTPase Binding Identical Protein Binding Protein Homodimerization Activity Protein Serine/threonine Kinase Activator Activity
	Biological Process	Behavioral Fear Response Receptor Recycling Response To Oxidative Stress Endosome Organization Lysosomal Transport Neuromuscular Junction Development Locomotory Behavior Intracellular Protein Localization Vesicle Organization Endosomal Transport Positive Regulation Of Rac Protein Signal Transduction Synaptic Transmission, Glutamatergic Positive Regulation Of GTPase Activity Positive Regulation Of Protein Kinase Activity Neuron Projection Morphogenesis Regulation Of Endosome Size Protein Homooligomerization Regulation Of Biological Quality Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels
Pathways		RAB GEFs exchange GTP for GDP on RABs RAC1 GTPase cycle
Drugs
Diseases		Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease Juvenile primary lateral sclerosis
GWAS		Perceived intensity of neohesperidin dihydrochalcone ( 31005972) Perceived intensity of sweet substances ( 31005972)
Novel Interacting Genes		4 novel interacting genes: IMPDH2 PPIL3 SUN2 YWHAB
Interacting Genes		4 interacting genes: IMPDH2 PPIL3 SUN2 YWHAB
Entrez ID		57679
HPRD ID		05893
Ensembl ID		ENSG00000003393
Uniprot IDs		A0A7P0T8F3 A0A7P0Z4I4 A8K4R4 Q96Q42
PDB IDs
Enriched GO Terms of Interacting Partners?		IMP Dehydrogenase Activity Nuclear Migration Along Microfilament Nuclear Migration Along Microtubule Nuclear Matrix Organization Nucleokinesis Involved In Cell Motility In Cerebral Cortex Radial Glia Guided Migration Nuclear Matrix Anchoring At Nuclear Membrane GTP Biosynthetic Process 'de Novo' XMP Biosynthetic Process Phosphoserine Residue Binding Cytoskeleton-nuclear Membrane Anchor Activity Meiotic Nuclear Membrane Microtubule Tethering Complex
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