CBY1 and RALBP1

Number of citations of the paper that reports this interaction (PubMedID 28514442)
50

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		CBY1	RALBP1
Description		chibby 1, beta catenin antagonist	ralA binding protein 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Trans-Golgi Network Centrosome Centriole Cytosol Cytoskeleton Cilium Nuclear Speck Motile Cilium Ciliary Basal Body Sperm Flagellum Cell Projection	Spindle Pole Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Cytoskeleton Plasma Membrane Membrane Nuclear Body
	Molecular Function	Protein Binding Beta-catenin Binding Identical Protein Binding Protein Homodimerization Activity	Nucleotide Binding GTPase Activator Activity Protein Binding ATP Binding ABC-type Xenobiotic Transporter Activity ABC-type Glutathione S-conjugate Transporter Activity Transmembrane Transporter Activity Small GTPase Binding ATPase-coupled Transmembrane Transporter Activity Xenobiotic Transmembrane Transporter Activity
	Biological Process	Intracellular Protein Localization Cell Projection Organization Cell Differentiation Negative Regulation Of Wnt Signaling Pathway Floor Plate Development Fat Cell Differentiation Negative Regulation Of DNA-templated Transcription Protein Homotetramerization Cardiac Muscle Cell Differentiation Canonical Wnt Signaling Pathway Cilium Assembly Negative Regulation Of Canonical Wnt Signaling Pathway	Positive Regulation Of Protein Phosphorylation Receptor-mediated Endocytosis Chemotaxis Signal Transduction Small GTPase-mediated Signal Transduction Regulation Of Cdc42 Protein Signal Transduction Regulation Of GTPase Activity Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Transmembrane Transport Positive Regulation Of Mitochondrial Fission Doxorubicin Transport Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane
Pathways		Deactivation of the beta-catenin transactivating complex	CDC42 GTPase cycle RAC1 GTPase cycle
Drugs
Diseases
GWAS		Resting heart rate ( 27798624) Sleep duration ( 30846698)	LDL cholesterol ( 30275531)
Interacting Genes		18 interacting genes: AGTPBP1 CDK6 CFAP53 CIBAR1 CLU CTNNB1 DDIAS DZIP1L ENKD1 FAM161B GORASP2 LNX1 NBPF11 RALBP1 RASSF10 TNFAIP8L3 TSG101 TTC23L	47 interacting genes: AMOTL2 AP2M1 C1orf216 CASP8 CBY1 CCDC13 CCDC136 CCDC88B CCHCR1 CCNB1 CEP57 CREBZF DLG4 DRC4 FADD GSE1 HOOK2 HSF1 HSPA13 IKBKG ITSN1 KANK2 LDOC1 MSANTD4 PCM1 PLCG2 PPP1R13B PRKACA PRKCA RAC1 RALA RALB REPS1 REPS2 RHOU SAPCD2 SMARCE1 SYCE1 SYNJ2BP TBRG1 TCP10L TNIP1 TP53BP2 TRAF2 TSFM ZBTB38 ZNF707
Entrez ID		25776	10928
HPRD ID		09676	09013
Ensembl ID		ENSG00000100211	ENSG00000017797
Uniprot IDs		Q9Y3M2	Q15311
PDB IDs		4WRQ	2KWH 2KWI 2MBG 6ZQT 6ZRN
Enriched GO Terms of Interacting Partners?		Cytoskeleton Spindle Pole Ciliary Basal Body Cilium Cilium Organization Centriole Cytoplasm Centrosome Organelle Assembly Microtubule Cytoskeleton Cilium Assembly Establishment Of Organelle Localization Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Organelle Organization Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Plasma Membrane Bounded Cell Projection Assembly Cell Projection Assembly Ciliary Transition Zone Cell Projection Cyclin D3-CDK6 Complex T Cell Differentiation In Thymus Cyclin D1-CDK6 Complex Cyclin D2-CDK6 Complex Negative Regulation Of Myeloid Leukocyte Differentiation FBXO Family Protein Binding Establishment Of Protein Localization To Vacuole Perinuclear Endoplasmic Reticulum Lumen Positive Regulation Of Neurofibrillary Tangle Assembly Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Neuronal Signal Transduction Cellular Component Assembly Mesenchymal Stem Cell Differentiation Positive Regulation Of Determination Of Dorsal Identity Negative Regulation Of Mitotic Cell Cycle, Embryonic Beta-catenin-ICAT Complex Positive Regulation Of Neural Precursor Cell Proliferation Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Glial Cell Fate Determination Renal Inner Medulla Development Scrib-APC-beta-catenin Complex Organelle Localization Renal Outer Medulla Development Renal Vesicle Formation Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation Positive Regulation Of Branching Involved In Lung Morphogenesis Neural Plate Development Extracellular Transport Positive Regulation Of Ubiquitin-dependent Endocytosis Doxorubicin Transport	Positive Regulation Of Macrophage Differentiation Regulation Of Macrophage Differentiation Regulation Of Endocytosis Protein-macromolecule Adaptor Activity Intracellular Signaling Cassette Endocytosis Cellular Component Assembly Protein Binding Intracellular Signal Transduction Positive Regulation Of Immune System Process Regulation Of Vesicle-mediated Transport Cytosol Positive Regulation Of Execution Phase Of Apoptosis Positive Regulation Of Myeloid Leukocyte Differentiation Regulation Of Receptor-mediated Endocytosis Protein Kinase Binding Cytoplasmic Microtubule Organization Import Into Cell Death Effector Domain Binding Regulation Of Signal Transduction Centrosome Regulation Of Receptor Internalization Protein-containing Complex Organization Tumor Necrosis Factor Receptor Binding Ripoptosome CD95 Death-inducing Signaling Complex Protein-containing Complex Assembly Cell Death Response To Lipopolysaccharide Death-inducing Signaling Complex Positive Regulation Of Leukocyte Differentiation Ubiquitin Protein Ligase Binding Programmed Cell Death Identical Protein Binding Positive Regulation Of Cellular Component Organization Tumor Necrosis Factor Receptor Superfamily Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Myeloid Cell Differentiation Microtubule Cytoskeleton Organization Regulation Of Canonical NF-kappaB Signal Transduction Organelle Organization Apoptotic Signaling Pathway Positive Regulation Of Peptide Hormone Secretion TRAIL-activated Apoptotic Signaling Pathway Response To Molecule Of Bacterial Origin Positive Regulation Of Signal Transduction Positive Regulation Of Peptide Secretion Cytoskeleton Organization Regulation Of Cytokine Production
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