MAMDC2 and EFHC1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MAMDC2	EFHC1
Description		MAM domain containing 2	EF-hand domain containing 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Endoplasmic Reticulum Membrane	Spindle Pole Cytoplasm Centrosome Spindle Cytoskeleton Axonemal Microtubule Cilium Axoneme Motile Cilium Sperm Flagellum Cell Projection Neuronal Cell Body Mitotic Spindle Axonemal A Tubule Inner Sheath
	Molecular Function	Protein Binding	Calcium Ion Binding Protein Binding Alpha-tubulin Binding
	Biological Process		Mitotic Cytokinesis Mitotic Spindle Organization Cerebral Cortex Cell Migration Flagellated Sperm Motility Regulation Of Cell Division Cilium-dependent Cell Motility
Pathways
Drugs
Diseases			Idiopathic generalied epilepsies (IGEs), including: Childhood absence epilepsy (CAE); Juvenile absence epilepsy (JAE); Juvenile myoclonic epilepsy (JME); Epilepsy with generalized tonic-clonic seizures alone
GWAS		Corneal resistance factor ( 32716492) Intraocular pressure ( 29617998)	Atopic march ( 26542096) Clozapine-induced myocarditis in schizophrenia ( 32066683) Mean platelet volume ( 27863252) Perceived intensity of glucose ( 31005972) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) White blood cell count ( 32888494)
Interacting Genes		1 interacting genes: EFHC1	68 interacting genes: AKT1 CACNA1E CALCOCO2 CFAP161 CHCHD3 CIMIP1 DOK7 EFHC2 EIF4ENIF1 FMR1 GADD45B GAS2L2 GOLGA2 HOMER3 IHO1 IKZF3 IMP3 ITGB3BP KCNJ5-AS1 KCTD4 KRT15 KRT18 KRT75 LMO2 LRRC61 MAMDC2 MBD3L1 METTL27 MIIP MRNIP MTFR1L NQO2 NRIP3 NUP54 OIP5 PAX6 PBX1 PBX2 PMF1 PRR5L RCN1 REL RIMBP3 RNF125 SAPCD1 SELENOV SH3GLB2 SLAIN1 SNAI1 SORBS3 SPATA2 SYNGAP1 TCF4 TEKT1 TEX11 TLE5 TP53BP2 TRAF2 TRIP6 TRPM2 TSGA10IP TTC23L UBAP2 VBP1 WASF1 WHRN YJU2B ZBED1
Entrez ID		256691	114327
HPRD ID		14353	10583
Ensembl ID		ENSG00000165072	ENSG00000096093
Uniprot IDs		Q7Z304	B2CKC5 Q5JVL4
PDB IDs			7UNG 8J07
Enriched GO Terms of Interacting Partners?		Mitotic Cytokinesis Cytoskeleton-dependent Cytokinesis Alpha-tubulin Binding Sperm Flagellum Axonemal Microtubule Cerebral Cortex Cell Migration Microtubule Cytoskeleton Organization Involved In Mitosis Sperm Motility Forebrain Cell Migration Telencephalon Cell Migration Flagellated Sperm Motility Mitotic Spindle Organization Axoneme Cilium Movement Involved In Cell Motility Axonemal A Tubule Inner Sheath Cilium-dependent Cell Motility Mitotic Spindle Regulation Of Cell Division Spindle Organization Cilium Movement Spindle Pole Motile Cilium Spindle Neuronal Cell Body Microtubule-based Movement Microtubule Cytoskeleton Organization	Protein Binding
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