MBLAC1 and MYOZ2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MBLAC1	MYOZ2
Description		metallo-beta-lactamase domain containing 1	myozenin 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Cytoplasm Actin Cytoskeleton Sarcomere Z Disc
	Molecular Function	RNA Endonuclease Activity Protein Binding Hydrolase Activity Metal Ion Binding	Actin Binding Protein Binding Protein Phosphatase 2B Binding Telethonin Binding FATZ Binding
	Biological Process	Histone MRNA Metabolic Process MRNA 3'-end Processing Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle	Negative Regulation Of Transcription By RNA Polymerase II Skeletal Muscle Tissue Development Skeletal Muscle Fiber Adaptation Sarcomere Organization Negative Regulation Of Calcineurin-NFAT Signaling Cascade
Pathways
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Coronary artery disease ( 29212778) Hematocrit ( 32888494) Hemoglobin levels ( 32327693) Microalbuminuria in type 1 diabetes ( 31537649) Refractive error ( 32231278) Subcortical volume (MOSTest) ( 32665545)	HDL cholesterol levels ( 32203549) Immature fraction of reticulocytes ( 32888494) PR interval ( 32439900) Refractive error ( 32231278)
Interacting Genes		11 interacting genes: AGR2 C10orf55 FNDC8 INCA1 MYOZ2 NDUFAB1 POGZ RHOH TRAF2 TRIP13 VAC14	19 interacting genes: ACTN1 ACTN2 ACTN4 CRK DRICH1 ETF1 EWSR1 FLNC HSPB2 LDB3 MBLAC1 MKRN3 MYB PDLIM3 PPP3CA PPP3CB RBPMS WWOX ZDHHC17
Entrez ID		255374	51778
HPRD ID		18584	05724
Ensembl ID		ENSG00000214309	ENSG00000172399
Uniprot IDs		A4D2B0	Q9NPC6
PDB IDs		4V0H
Enriched GO Terms of Interacting Partners?			Z Disc Cytoskeletal Protein Binding Muscle Cell Development Pseudopodium Actin Cytoskeleton Organization Actin Filament-based Process Actin Binding Cell Development Stress Fiber Positive Regulation Of Cation Transmembrane Transport Positive Regulation Of Monoatomic Ion Transmembrane Transport Transcription Coactivator Activity Actin Cytoskeleton Sarcomere Organization Calmodulin-dependent Protein Phosphatase Activity Negative Regulation Of Calcium Ion Import Across Plasma Membrane Calcineurin Complex Cortical Actin Cytoskeleton Identical Protein Binding Positive Regulation Of Monoatomic Ion Transport Protein Serine/threonine Phosphatase Complex Platelet Alpha Granule Lumen Postsynaptic Actin Cytoskeleton Positive Regulation Of Calcium Ion Import Across Plasma Membrane Cytoskeleton Organization Enzyme Binding Actin Filament Binding Striated Muscle Cell Development Negative Regulation Of Calcium Ion Import Regulation Of Calcium Ion Import Across Plasma Membrane Muscle Alpha-actinin Binding Regulation Of Monoatomic Cation Transmembrane Transport Negative Regulation Of Monoatomic Ion Transport Positive Regulation Of Calcineurin-NFAT Signaling Cascade Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Calcineurin-NFAT Signaling Cascade Actomyosin Structure Organization Regulation Of Monoatomic Ion Transmembrane Transport Glutamatergic Synapse Positive Regulation Of Calcium Ion Import Positive Regulation Of RNA Metabolic Process Focal Adhesion Assembly Calcineurin-mediated Signaling Calcium Ion Binding Skeletal Muscle Fiber Development Filamentous Actin Transmembrane Transporter Binding Muscle Structure Development Regulation Of Metal Ion Transport
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