GAA and DYNC1LI2

Number of citations of the paper that reports this interaction (PubMedID 30217970)
38

Data Source:
BioGRID (two hybrid)

		GAA	DYNC1LI2
Description		alpha glucosidase	dynein cytoplasmic 1 light intermediate chain 2
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GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Plasma Membrane Membrane Azurophil Granule Membrane Lysosomal Lumen Extracellular Exosome Tertiary Granule Membrane Ficolin-1-rich Granule Membrane Autolysosome Lumen	Kinetochore Cytoplasm Late Endosome Centrosome Cytosol Cytoskeleton Cytoplasmic Dynein Complex Microtubule Membrane Dynein Complex
	Molecular Function	Catalytic Activity Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Alpha-1,4-glucosidase Activity Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Carbohydrate Binding Alpha-glucosidase Activity	Nucleotide Binding ATP Binding Identical Protein Binding Dynein Heavy Chain Binding
	Biological Process	Maltose Metabolic Process Regulation Of The Force Of Heart Contraction Diaphragm Contraction Heart Morphogenesis Carbohydrate Metabolic Process Glycogen Metabolic Process Glycogen Catabolic Process Disaccharide Metabolic Process Sucrose Metabolic Process Glucose Metabolic Process Striated Muscle Contraction Lysosome Organization Locomotory Behavior Tissue Development Aorta Development Vacuolar Sequestering Muscle Cell Cellular Homeostasis Neuromuscular Process Controlling Posture Neuromuscular Process Controlling Balance Cardiac Muscle Contraction Glycophagy	Microtubule Cytoskeleton Organization Microtubule-based Movement Positive Regulation Of Intracellular Transport Centrosome Localization Cellular Response To Nerve Growth Factor Stimulus
Pathways		Glycogen storage disease type II (GAA) Neutrophil degranulation Glycogen breakdown (glycogenolysis)	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase HCMV Early Events Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation
Drugs		Acarbose Miglitol AT2220 alpha-Arbutin
Diseases		Glycogen storage diseases (GSD), including: von Gierke disease (GSD type Ia); Pompe disease (GSD type II); Cori disease, Forbe disease (GSD type III); Andersen disease (GSD type IV); McArdle disease (GSD type V); Hers disease (GSD type VI); Tarui disease (GSD type VII); Phosphorylase kinase deficiency (GSD type IX); Fanconi-Bickel syndrome (GSD type XI); Glycogen synthase deficiency (GSD type 0)
GWAS		Blood protein levels ( 30072576) Platelet distribution width ( 32888494) Plateletcrit ( 32888494)	Lipid traits ( 30576415)
Interacting Genes		11 interacting genes: CPEB2 CREBBP DYNC1LI2 EP300 HIVEP1 NCF1 NUMBL PARD3B RAB2A SH3GLB2 STAT2	10 interacting genes: APP BRCA2 CTRL DMTN FCSK GAA HPR LINC00632 OGT ZFHX3
Entrez ID		2548	1783
HPRD ID		06006	09923
Ensembl ID		ENSG00000171298	ENSG00000135720
Uniprot IDs		P10253	O43237
PDB IDs		5KZW 5KZX 5NN3 5NN4 5NN5 5NN6 5NN8 7P2Z 7P32	6F1T 6F1Y 6F38 6F3A 7Z8F 7Z8I 7Z8J 7Z8K 7Z8L 8PR0 8PR1 8PR2 8PR3 8PTK
Enriched GO Terms of Interacting Partners?		Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Histone H3K27 Acetyltransferase Activity Peptide Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Acetylation N-terminal Protein Amino Acid Acetylation Regulation Of Cellular Response To Heat Acetyltransferase Activity Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Histone Acetyltransferase Complex Protein-lysine-acetyltransferase Activity Regulation Of Innate Immune Response Protein Acetylation Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Histone Acetyltransferase Activity Centrosome Localization Tau Protein Binding Transcription Coactivator Binding Protein Destabilization Canonical NF-kappaB Signal Transduction Peptidyl-lysine Propionylation Swimming Histone Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity Histone Crotonyltransferase Activity Negative Regulation Of Cytoplasmic Translational Elongation Damaged DNA Binding Response To Hypoxia Cell Surface Receptor Signaling Pathway Via JAK-STAT Cytoplasm P53 Binding Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Response To Decreased Oxygen Levels Response To Oxygen Levels Histone H2B Acetyltransferase Activity Cell Surface Receptor Signaling Pathway Via STAT Acetylation-dependent Protein Binding Peptide Butyryltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Protein Propionyltransferase Activity Peptide Crotonyltransferase Activity Neutrophil-mediated Killing Of Fungus Chromatin DNA Binding Regulation Of Defense Response Cellular Response To UV Positive Regulation Of Protein Localization To Nucleus	Hemopoiesis Acetylcholine Receptor Activator Activity Amyloid-beta Complex Regulation Of Cell Junction Assembly Regulation Of ATP Metabolic Process Growth Cone Lamellipodium Myeloid Cell Development Regulation Of Response To Calcium Ion Regulation Of Carbohydrate Catabolic Process Regulation Of Glycolytic Process Amylin Binding Regulation Of Purine Nucleotide Metabolic Process Positive Regulation Of Toll Signaling Pathway Cellular Homeostasis Cellular Response To CAMP Cell Development Lipoprotein Particle Positive Regulation Of Protein Import Response To CAMP Circadian Regulation Of Gene Expression Regulation Of Locomotor Rhythm Mitotic Recombination-dependent Replication Fork Processing BRCA2-MAGE-D1 Complex Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Autolysosome Lumen Sucrose Metabolic Process Vacuolar Sequestering Maltose Metabolic Process Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Fucokinase Activity GDP-L-fucose Salvage PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Diaphragm Contraction Alpha-1,4-glucosidase Activity Protein O-acetylglucosaminyltransferase Activity Regulation Of Spontaneous Synaptic Transmission Response To Purine-containing Compound Positive Regulation Of Mitotic Cell Cycle Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle
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