RICTOR and SIAH1

		RICTOR	SIAH1
Description		RPTOR independent companion of MTOR complex 2	siah E3 ubiquitin protein ligase 1
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GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Plasma Membrane Membrane TORC2 Complex Serine/threonine Protein Kinase Complex	Nucleus Cytoplasm Early Endosome Cytosol Beta-catenin Destruction Complex
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Zinc Ion Binding Protein Kinase Binding Ribosome Binding Protein Serine/threonine Kinase Activator Activity Molecular Adaptor Activity Enzyme-substrate Adaptor Activity	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin Conjugating Enzyme Binding Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Positive Regulation Of Endothelial Cell Proliferation Cytoskeleton Organization Lipid Biosynthetic Process Embryo Development Ending In Birth Or Egg Hatching Regulation Of Gene Expression Actin Cytoskeleton Organization Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Positive Regulation Of Actin Filament Polymerization Cellular Response To Nutrient Levels TOR Signaling Positive Regulation Of TOR Signaling Regulation Of Actin Cytoskeleton Organization TORC2 Signaling Negative Regulation Of Apoptotic Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Inflammatory Response Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction CGAS/STING Signaling Pathway Negative Regulation Of CGAS/STING Signaling Pathway Regulation Of Establishment Of Cell Polarity	Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Spermatogenesis Nervous System Development Axon Guidance Anatomical Structure Morphogenesis Protein Ubiquitination Cell Differentiation Protein Catabolic Process Protein Destabilization Positive Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Neuron Apoptotic Process Canonical Wnt Signaling Pathway Amyloid Fibril Formation Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		PIP3 activates AKT signaling CD28 dependent PI3K/Akt signaling VEGFR2 mediated vascular permeability Constitutive Signaling by AKT1 E17K in Cancer Regulation of TP53 Degradation High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	Netrin-1 signaling Amyloid fiber formation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Daytime sleep phenotypes ( 27126917) Immature fraction of reticulocytes ( 32888494) Obesity-related traits ( 23251661) Post bronchodilator FEV1 ( 26634245) Red blood cell count ( 32888494)	Femur bone mineral density x serum urate levels interaction ( 34046847) Height ( 28552196) Mean corpuscular hemoglobin ( 32888494) Waist circumference ( 28552196)
Interacting Genes		19 interacting genes: ANXA10 CHUK CTSW CUL1 EIF4EBP1 GSK3A GSK3B IFT20 IKBKB MROH2B MTOR PHKB PLCXD3 PLK1 RIMOC1 SGK1 SIAH1 SIRT1 USP9X	158 interacting genes: AASDHPPT AFF1 AFF4 APC AQP1 ARMC9 ATN1 ATXN7 AXIN1 AXIN2 BAG1 BAG3 BAG4 BCL6 CACYBP CAPG CCDC198 CDC23 CDC34 CDK5R1 COPS5 DAB1 DAZAP2 DCC DDX41 DNAJC15 DNALI1 EEF1D EIF3J ELL2 EXOC3-AS1 FAM90A1 FLI1 FZD9 GAPDH GDPD5 GRM5 H4C16 HCFC1 HIF1AN HIPK2 HIPK3 INHA IQCN ITSN1 KATNAL1 KCNJ10 KHDRBS3 KIAA0319L KIAA1217 KIF1B KIF22 KIFC3 KLF10 LACTB2 LANCL2 LMNA M1AP MAB21L1 MAP3K5 MAPK12 MAPKBP1 MAPRE3 MOB3C MTIF3 MX1 NANOS2 NANOS3 NECTIN2 NELFA NHERF2 NOL6 NTAQ1 NUMB NUMBL OPRM1 OTUB2 PARD6B PCDH17 PEG10 PEG3 PFKM PHC1 PHC2 PIAS2 PIAS3 PIMREG PINK1 PKD1 POU2AF1 PRPF31 PRR20B PRR20C PRR20D PRR20E PTPMT1 PUF60 PYGB QRICH1 RAB33A RAB33B RAD51AP1 RAD54L2 RAPH1 RBBP8 RICTOR RPL27A RPS19BP1 RXRB SDCBP SFMBT2 SH3RF1 SLAIN1 SNCAIP SPATA4 SPATC1L SYP SYT7 TBC1D22B TERF2 TFDP1 TMEM43 TNK2 TOLLIP TP53BP2 TRIM23 TRIM27 TRIM7 TRIM8 TUBA1A TUBA1B TUBA3C TUBA4A TUBA8 TXN UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E3 UBE2I UBE2K UBE2L6 UBE2N UBE2V2 UPP2 USP19 UXT VAV1 ZBP1 ZCCHC10 ZCCHC13 ZFYVE21 ZMAT3 ZNF148 ZNF512B ZNF671 ZYX
Entrez ID		253260	6477
HPRD ID		10682	03736
Ensembl ID		ENSG00000164327	ENSG00000196470
Uniprot IDs		A0AA34QVX7 D6R9S6 Q6R327	Q8IUQ4
PDB IDs		5ZCS 6ZWM 6ZWO 7PE7 7PE8 7PE9 7TZO	2A25 4C9Z 4CA1 4I7B 4I7C 4I7D 4X3G 5WZZ 8HEO 9G0L
Enriched GO Terms of Interacting Partners?		Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of TOR Signaling Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of TOR Signaling Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Serine/threonine Kinase Activity Positive Regulation Of Proteasomal Protein Catabolic Process Beta-catenin Destruction Complex Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of TORC2 Signaling Protein Destabilization Regulation Of Cellular Response To Heat Protein Kinase Activity Cytoplasm Signal Transduction Energy Reserve Metabolic Process Positive Regulation Of Autophagy Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen (starch) Synthase Activity Protein Serine Kinase Activity TOR Signaling Regulation Of Protein Catabolic Process Positive Regulation Of Proteolysis Regulation Of Proteolysis Kinase Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process IkappaB Kinase Activity Proteolysis Involved In Protein Catabolic Process Intracellular Signal Transduction Negative Regulation Of TORC2 Signaling Regulation Of Glycogen (starch) Synthase Activity Regulation Of Organelle Assembly Proteasomal Protein Catabolic Process Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Peptidyl-serine Phosphorylation Regulation Of Intracellular Signal Transduction Proteolysis Positive Regulation Of Signal Transduction Mitotic Cell Cycle Phase Transition Positive Regulation Of Catabolic Process Ubiquitin-dependent Protein Catabolic Process IkappaB Kinase Complex Modification-dependent Protein Catabolic Process Cellular Response To Interleukin-3 Cell Cycle Phase Transition Regulation Of Type B Pancreatic Cell Development	Nucleus Ubiquitin Conjugating Enzyme Activity Protein Binding Ubiquitin Protein Ligase Binding Nucleoplasm Cytoplasm Protein Modification By Small Protein Conjugation Protein Polyubiquitination Perinuclear Region Of Cytoplasm Microtubule Cytoskeleton Post-translational Protein Modification Identical Protein Binding Beta-catenin Destruction Complex Ubiquitin-protein Transferase Activity Protein K48-linked Ubiquitination Nuclear Body Regulation Of JNK Cascade Regulation Of Nucleobase-containing Compound Metabolic Process Nucleotide Binding Protein Ubiquitination Cell Death Microtubule-based Process Apoptotic Process SUMO Transferase Activity Negative Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Programmed Cell Death Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein K63-linked Ubiquitination Regulation Of Primary Metabolic Process Microtubule Cytoskeleton Organization Microtubule Regulation Of Macromolecule Metabolic Process Microtubule Binding Organelle Organization Regulation Of Metabolic Process Ubiquitin-dependent Protein Catabolic Process Lateral Ventricle Development Astrocyte Projection Positive Regulation Of Post-translational Protein Modification Establishment Of Mitochondrion Localization UBC13-MMS2 Complex Neuroblast Division In Subventricular Zone Modification-dependent Protein Catabolic Process Regulation Of DNA-templated Transcription Adenyl-nucleotide Exchange Factor Activity Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process
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