RICTOR and ANXA10

		RICTOR	ANXA10
Description		RPTOR independent companion of MTOR complex 2	annexin A10
Image			No pdb structure
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Plasma Membrane Membrane TORC2 Complex Serine/threonine Protein Kinase Complex	Nucleus Cytoplasm Plasma Membrane Vesicle Membrane
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Zinc Ion Binding Protein Kinase Binding Ribosome Binding Protein Serine/threonine Kinase Activator Activity Molecular Adaptor Activity Enzyme-substrate Adaptor Activity	Phosphatidylserine Binding Calcium Ion Binding Protein Binding Calcium-dependent Phospholipid Binding
	Biological Process	Positive Regulation Of Endothelial Cell Proliferation Cytoskeleton Organization Lipid Biosynthetic Process Embryo Development Ending In Birth Or Egg Hatching Regulation Of Gene Expression Actin Cytoskeleton Organization Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Positive Regulation Of Actin Filament Polymerization Cellular Response To Nutrient Levels TOR Signaling Positive Regulation Of TOR Signaling Regulation Of Actin Cytoskeleton Organization TORC2 Signaling Negative Regulation Of Apoptotic Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Inflammatory Response Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction CGAS/STING Signaling Pathway Negative Regulation Of CGAS/STING Signaling Pathway Regulation Of Establishment Of Cell Polarity
Pathways		PIP3 activates AKT signaling CD28 dependent PI3K/Akt signaling VEGFR2 mediated vascular permeability Constitutive Signaling by AKT1 E17K in Cancer Regulation of TP53 Degradation High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs
Diseases
GWAS		Daytime sleep phenotypes ( 27126917) Immature fraction of reticulocytes ( 32888494) Obesity-related traits ( 23251661) Post bronchodilator FEV1 ( 26634245) Red blood cell count ( 32888494)	Plasma anti-thyroglobulin and anti-thyroid peroxidase levels (bivariate analysis) ( 29678681) Pursuit maintenance gain ( 29064472) Verbal declarative memory ( 25648963)
Interacting Genes		19 interacting genes: ANXA10 CHUK CTSW CUL1 EIF4EBP1 GSK3A GSK3B IFT20 IKBKB MROH2B MTOR PHKB PLCXD3 PLK1 RIMOC1 SGK1 SIAH1 SIRT1 USP9X	5 interacting genes: BLVRB CLCN3 EDC3 NEK1 RICTOR
Entrez ID		253260	11199
HPRD ID		10682	09724
Ensembl ID		ENSG00000164327	ENSG00000109511
Uniprot IDs		A0AA34QVX7 D6R9S6 Q6R327	Q9UJ72
PDB IDs		5ZCS 6ZWM 6ZWO 7PE7 7PE8 7PE9 7TZO
Enriched GO Terms of Interacting Partners?		Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of TOR Signaling Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of TOR Signaling Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Serine/threonine Kinase Activity Positive Regulation Of Proteasomal Protein Catabolic Process Beta-catenin Destruction Complex Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of TORC2 Signaling Protein Destabilization Regulation Of Cellular Response To Heat Protein Kinase Activity Cytoplasm Signal Transduction Energy Reserve Metabolic Process Positive Regulation Of Autophagy Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen (starch) Synthase Activity Protein Serine Kinase Activity TOR Signaling Regulation Of Protein Catabolic Process Positive Regulation Of Proteolysis Regulation Of Proteolysis Kinase Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process IkappaB Kinase Activity Proteolysis Involved In Protein Catabolic Process Intracellular Signal Transduction Negative Regulation Of TORC2 Signaling Regulation Of Glycogen (starch) Synthase Activity Regulation Of Organelle Assembly Proteasomal Protein Catabolic Process Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Peptidyl-serine Phosphorylation Regulation Of Intracellular Signal Transduction Proteolysis Positive Regulation Of Signal Transduction Mitotic Cell Cycle Phase Transition Positive Regulation Of Catabolic Process Ubiquitin-dependent Protein Catabolic Process IkappaB Kinase Complex Modification-dependent Protein Catabolic Process Cellular Response To Interleukin-3 Cell Cycle Phase Transition Regulation Of Type B Pancreatic Cell Development	Riboflavin Reductase (NADPH) Activity FMN Reductase (NADPH) Activity FMN Reductase (NADH) Activity Biliverdin Reductase [NAD(P)H] Activity Chloride:proton Antiporter Activity Peptidyl-cysteine S-nitrosylase Activity
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