TRPC3 and SLC8A1

Number of citations of the paper that reports this interaction (PubMedID 14736881)
0

Data Source:
HPRD (in vivo, in vitro)

		TRPC3	SLC8A1
Description		transient receptor potential cation channel subfamily C member 3	solute carrier family 8 member A1
Image
GO Annotations	Cellular Component	Plasma Membrane Membrane Cation Channel Complex	Nucleoplasm Plasma Membrane Postsynaptic Density Intercalated Disc Membrane Z Disc T-tubule Axon Dendrite Sarcolemma Neuronal Cell Body Axon Terminus Synapse Cell Periphery Postsynapse
	Molecular Function	Monoatomic Ion Channel Activity Calcium-activated Cation Channel Activity Calcium Channel Activity Protein Binding Store-operated Calcium Channel Activity Metal Ion Binding Inositol 1,4,5 Trisphosphate Binding	Calcium:sodium Antiporter Activity Calcium Ion Binding Protein Binding Calmodulin Binding Cytoskeletal Protein Binding Antiporter Activity Ankyrin Binding Transmembrane Transporter Binding Metal Ion Binding
	Biological Process	Monoatomic Ion Transport Calcium Ion Transport Single Fertilization Phototransduction Positive Regulation Of Calcium Ion Transport Into Cytosol Response To ATP Monoatomic Ion Transmembrane Transport Regulation Of Cytosolic Calcium Ion Concentration Response To Calcium Ion Transmembrane Transport Calcium Ion Transmembrane Transport Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress	Regulation Of The Force Of Heart Contraction Regulation Of Heart Rate Monoatomic Ion Transport Sodium Ion Transport Calcium Ion Transport Intracellular Calcium Ion Homeostasis Intracellular Sodium Ion Homeostasis Muscle Contraction Cell Communication Regulation Of Gene Expression Regulation Of Cell Communication By Electrical Coupling Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Vascular Associated Smooth Muscle Contraction Positive Regulation Of Bone Mineralization Cellular Response To Reactive Oxygen Species Sodium Ion Transmembrane Transport Response To Muscle Stretch Sodium Ion Export Across Plasma Membrane Relaxation Of Smooth Muscle Negative Regulation Of Cytosolic Calcium Ion Concentration Cardiac Muscle Cell Development Calcium Ion Homeostasis Transmembrane Transport Relaxation Of Cardiac Muscle Cardiac Muscle Contraction Calcium Ion Transport Into Cytosol Calcium Ion Import Calcium Ion Transmembrane Transport Cellular Response To Caffeine Membrane Depolarization During Cardiac Muscle Cell Action Potential Cell Communication By Electrical Coupling Involved In Cardiac Conduction Calcium Ion Transmembrane Import Into Cytosol Calcium Ion Import Across Plasma Membrane Sodium Ion Import Across Plasma Membrane Positive Regulation Of The Force Of Heart Contraction Calcium Ion Export Negative Regulation Of Intracellular Signal Transduction Regulation Of Cardiac Conduction
Pathways		Effects of PIP2 hydrolysis Elevation of cytosolic Ca2+ levels TRP channels Role of second messengers in netrin-1 signaling MECP2 regulates neuronal receptors and channels	Reduction of cytosolic Ca++ levels Sodium/Calcium exchangers Ion homeostasis
Drugs			alpha-Linolenic acid Icosapent Dronedarone Caldaret
Diseases
GWAS		Asthma ( 31959851 34103634) Celiac disease and Rheumatoid arthritis ( 26546613) Emphysema imaging phenotypes ( 26030696) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Rosacea symptom severity ( 29771307)	Adult body size ( 32376654) Appendicular lean mass ( 33097823) Asthma ( 27611488) Chronotype ( 30696823) Diastolic blood pressure ( 28135244) Early spontaneous preterm birth ( 31194736) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits ( 25055868) Electrocardiographic traits (multivariate) ( 32602732) Estimated glomerular filtration rate ( 31451708 31152163) Estimated glomerular filtration rate in non-diabetics ( 31451708) Fasting glucose ( 34059833) Fractional exhaled nitric oxide levels ( 25431337) Fractures ( 30598549 30158200) Hand grip strength ( 29691431 29313844) Heel bone mineral density ( 30598549 28869591) HIV-associated dementia ( 22628157) Immune response to measles-mumps-rubella vaccine ( 24811271) Lymphocyte percentage of white cells ( 32888494) Mitochondrial DNA levels ( 25240745) Neutrophil percentage of white cells ( 32888494) Obesity (early onset extreme) ( 23563609) Obesity-related traits ( 23251661) PR interval ( 25035420 32439900 29127183) Proportion of activated microglia (inferior temporal cortex) ( 30679421) QT interval ( 24952745 29213071 22726844) Refractive error ( 32231278) Serum immune biomarker levels ( 32066700) Systolic blood pressure ( 30578418) Tea consumption ( 31046077) Total body bone mineral density ( 29304378) TPE interval (resting) ( 32386560) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		22 interacting genes: BBS7 CALM1 FKBP1A FNDC5 GNA11 ITPR1 ITPR3 MX1 NAPA ORAI1 PLCB1 PLCB2 PLCB3 PLCG1 PRKCA PRKG1 SLC8A1 STX3 TRPC1 TRPC6 TRPC7 VAMP2	8 interacting genes: AKAP6 CAV3 FXYD1 PPP3CB TRPC3 YWHAB YWHAE YWHAQ
Entrez ID		7222	6546
HPRD ID		15999	01659
Ensembl ID		ENSG00000138741	ENSG00000183023
Uniprot IDs		Q13507	A0A994J4U7 A0A994J7E1 A0A994J7G2 E9PB98 P32418 Q4QQH3
PDB IDs		5ZBG 6CUD 6D7L 6DJS 7DXB 7DXC 7DXD 7DXE	8JP0 8SGI 8SGJ 8SGT
Enriched GO Terms of Interacting Partners?		Regulation Of Sequestering Of Calcium Ion Calcium Ion Transmembrane Transport Calcium Ion Transport Metal Ion Transport Inositol 1,4,5 Trisphosphate Binding Calcium Ion Transmembrane Import Into Cytosol Monoatomic Cation Transport Inorganic Cation Transmembrane Transport Monoatomic Cation Transmembrane Transport Release Of Sequestered Calcium Ion Into Cytosol Phosphatidylinositol Phospholipase C Activity Negative Regulation Of Sequestering Of Calcium Ion Monoatomic Ion Transport Inorganic Ion Transmembrane Transport Store-operated Calcium Channel Activity Monoatomic Ion Transmembrane Transport Calcium Channel Activity Calcium-mediated Signaling Phospholipase C Activity Regulation Of Metal Ion Transport Regulation Of Transport Regulation Of Calcium Ion Transport Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Regulation Of Monoatomic Ion Transport Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Insulin Secretion Plasma Membrane Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway Ligand-gated Ion Channel Signaling Pathway Calcium Ion Homeostasis Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Intracellular Signal Transduction Positive Regulation Of Transport Calcium Ion Binding Phosphoric Diester Hydrolase Activity Intracellular Signaling Cassette Positive Regulation Of Protein Transport Long-term Synaptic Potentiation Regulation Of Hormone Secretion Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Monoatomic Cation Transmembrane Transport Positive Regulation Of Protein Localization Regulation Of Calcium Ion Transmembrane Transport Positive Regulation Of Protein Secretion Positive Regulation Of Hormone Secretion	Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Monoatomic Ion Transport Regulation Of Monoatomic Cation Transmembrane Transport Transmembrane Transporter Binding Regulation Of Metal Ion Transport T-tubule Regulation Of Transport Regulation Of Calcium Ion Transport Negative Regulation Of Monoatomic Ion Transmembrane Transport Negative Regulation Of Monoatomic Ion Transport Negative Regulation Of Transmembrane Transport Positive Regulation Of Cation Transmembrane Transport Positive Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Transport Regulation Of Calcium Ion Transmembrane Transport Regulation Of Membrane Repolarization Negative Regulation Of Transport Positive Regulation Of Monoatomic Ion Transport Intercalated Disc Protein Targeting Negative Regulation Of Calcium Ion Transport Regulation Of Cytosolic Calcium Ion Concentration Regulation Of System Process Positive Regulation Of Calcium Ion Transmembrane Transport Phosphoserine Residue Binding Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Cation Transmembrane Transport Regulation Of Cardiac Muscle Hypertrophy Caveola Regulation Of Potassium Ion Transport Positive Regulation Of Calcium Ion Transport Enzyme Binding Focal Adhesion Regulation Of Membrane Potential Positive Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of Cellular Localization Intracellular Calcium Ion Homeostasis Regulation Of Heart Contraction Sodium Channel Regulator Activity Negative Regulation Of Protein Localization Calcium Ion Homeostasis Regulation Of Calcineurin-mediated Signaling Regulation Of Calcineurin-NFAT Signaling Cascade Positive Regulation Of Cardiac Muscle Hypertrophy Protein Domain Specific Binding Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Calcium Ion Transmembrane Transport Phosphoprotein Binding Regulation Of Muscle System Process
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