EML2 and RFC5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		EML2	RFC5
Description		EMAP like 2	replication factor C subunit 5
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GO Annotations	Cellular Component	Cytoplasm Spindle Cytoskeleton Microtubule Microtubule Associated Complex Mitotic Spindle	Nucleus Nucleoplasm DNA Replication Factor C Complex Chromosome Ctf18 RFC-like Complex
	Molecular Function	Protein Binding Microtubule Binding Tubulin Binding	Nucleotide Binding DNA Binding DNA Clamp Loader Activity Protein Binding ATP Binding ATP Hydrolysis Activity Single-stranded DNA Helicase Activity Enzyme Binding
	Biological Process	Microtubule Cytoskeleton Organization Visual Perception Sensory Perception Of Sound Regulation Of Microtubule Nucleation Negative Regulation Of Microtubule Polymerization	DNA Replication DNA-templated DNA Replication DNA Repair Positive Regulation Of DNA-directed DNA Polymerase Activity
Pathways			Translesion synthesis by REV1 Recognition of DNA damage by PCNA-containing replication complex Translesion Synthesis by POLH Polymerase switching on the C-strand of the telomere Activation of ATR in response to replication stress PCNA-Dependent Long Patch Base Excision Repair Translesion synthesis by POLK Translesion synthesis by POLI Termination of translesion DNA synthesis HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Regulation of TP53 Activity through Phosphorylation Polymerase switching G2/M DNA damage checkpoint Impaired BRCA2 binding to RAD51
Drugs
Diseases
GWAS		Fruit consumption ( 32066663) Hemoglobin A1c levels ( 29403010) Subcutaneous adipose tissue ( 22589738) Type 2 diabetes ( 32499647)	Chronic rhinosinusitis ( 33393196) Metabolite levels ( 23823483) Neurociticism ( 29500382) Obesity-related traits ( 23251661) Physiological traits ( 31902109)
Interacting Genes		13 interacting genes: BPIFA1 EIF3F EXD1 IFI35 IFT88 KLHDC2 PLEKHF2 PTTG2 REL RFC5 SNX32 SPANXA1 SPANXA2	37 interacting genes: ARID5A BIRC2 CCNC CEBPA CHTF18 CIMIP2B COPS6 DAPK1 DDIT4L DYNLL1 EEF1A1 EML2 EXOSC8 KRT34 LMO3 LRIF1 MED31 N4BP3 NAB2 NR5A1 PCNA PPP1R16B PTEN RBM48 RFC2 RFC4 SUMO2 TASOR2 TRIM38 TSNAX UNC119 XAF1 XIAP YPEL3 ZMAT1 ZNF19 ZNF426
Entrez ID		24139	5985
HPRD ID		16860	02677
Ensembl ID		ENSG00000125746	ENSG00000111445
Uniprot IDs		O95834	P40937 Q59GW7
PDB IDs		4CGB	6VVO 7Z6H 8UI7 8UI8 8UI9 8UII 8UMT 8UMU 8UMV 8UMW 8UMY 8UN0 8UNJ
Enriched GO Terms of Interacting Partners?			Positive Regulation Of DNA-directed DNA Polymerase Activity Regulation Of Macromolecule Metabolic Process Ctf18 RFC-like Complex Regulation Of Metabolic Process DNA Clamp Loader Activity Nucleus Positive Regulation Of DNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Single-stranded DNA Helicase Activity Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA Biosynthetic Process Nucleoplasm DNA Replication Factor C Complex Positive Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Enzyme Binding DNA Replication DNA Strand Elongation Involved In DNA Replication Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Positive Regulation Of Catalytic Activity Positive Regulation Of Protein Polyubiquitination DNA Strand Elongation Identical Protein Binding Protein-containing Complex Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process
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