IFIT5 and IFIT3

Number of citations of the paper that reports this interaction (PubMedID 21163940)
58

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		IFIT5	IFIT3
Description		interferon induced protein with tetratricopeptide repeats 5	interferon induced protein with tetratricopeptide repeats 3
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GO Annotations	Cellular Component	Cytosol Plasma Membrane IkappaB Kinase Complex Actin Cytoskeleton Membrane Ruffle Membrane Cell Projection Apical Part Of Cell	Cytoplasm Mitochondrion Cytosol
	Molecular Function	TRNA Binding RNA Cap Binding Double-stranded DNA Binding RNA Binding Single-stranded RNA Binding Protein Binding Poly(U) RNA Binding	Protein Binding Identical Protein Binding
	Biological Process	Immune System Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Viral Genome Replication Innate Immune Response Defense Response To Virus	Immune System Process Negative Regulation Of Cell Population Proliferation Response To Virus Negative Regulation Of Apoptotic Process Innate Immune Response Defense Response To Virus Antiviral Innate Immune Response
Pathways		Interferon alpha/beta signaling	Interferon alpha/beta signaling
Drugs
Diseases
GWAS			Hormone measurements ( 30576415)
Interacting Genes		16 interacting genes: A2M APOE CDC37 ECSIT H19 IFIT3 LONP1 MAST1 PRDX2 PSEN2 RAD23A RNF32 SARAF SRPK1 SRPK2 TTC3	21 interacting genes: A2M ANXA1 APOE CYP2C8 DEUP1 ECSIT FANCA HAUS1 IFIT1 IFIT1B IFIT2 IFIT5 LONP1 LVRN MAST1 PSEN2 RAD23A RNF32 TMEM183A TPM1 TPM3
Entrez ID		24138	3437
HPRD ID		17130	05228
Ensembl ID		ENSG00000152778	ENSG00000119917
Uniprot IDs		Q13325	A0A7P0T7D6 O14879 Q5T765
PDB IDs		3ZGQ 4HOQ 4HOR 4HOS 4HOT 4J0U	6C6K
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Viral Genome Replication Positive Regulation Of Viral Process Regulation Of Viral Genome Replication Regulation Of Viral Life Cycle Antioxidant Activity Amyloid Precursor Protein Metabolic Process Regulation Of Viral Process Regulation Of Innate Immune Response Negative Regulation Of Phospholipid Efflux Negative Regulation Of Postsynaptic Membrane Organization Positive Regulation Of Lipid Transport Across Blood-brain Barrier Response To Stress Negative Regulation Of Lipid Transport Across Blood-brain Barrier Regulation Of Cellular Response To Very-low-density Lipoprotein Particle Stimulus Metal Chelating Activity Intermediate-density Lipoprotein Particle Clearance Magnesium Ion Binding Spliceosomal Complex Assembly Negative Regulation Of Viral Genome Replication Respiratory Burst Involved In Inflammatory Response Oxidation-dependent Protein Catabolic Process Negative Regulation Of Complement Activation, Lectin Pathway Positive Regulation Of Presynaptic Membrane Organization Chylomicron Remnant Lipid Transport Involved In Lipid Storage Lipoprotein Particle Positive Regulation Of Neurofibrillary Tangle Assembly Discoidal High-density Lipoprotein Particle HSP90-CDC37 Chaperone Complex Regulation Of Blood Coagulation Regulation Of Hemostasis	Negative Regulation Of Viral Translation RNA Sequestering Activity Muscle Thin Filament Tropomyosin Regulation Of Viral Process Response To Stress Negative Regulation Of Viral Process Regulation Of Viral Genome Replication Actin Filament Amyloid Precursor Protein Metabolic Process Defense Response To Virus Regulation Of Viral Life Cycle Innate Immune Response Negative Regulation Of Phospholipid Efflux Negative Regulation Of Postsynaptic Membrane Organization Positive Regulation Of Lipid Transport Across Blood-brain Barrier Negative Regulation Of Lipid Transport Across Blood-brain Barrier Regulation Of Cellular Response To Very-low-density Lipoprotein Particle Stimulus Metal Chelating Activity Intermediate-density Lipoprotein Particle Clearance Response To Virus Positive Regulation Of Viral Genome Replication Positive Regulation Of Heart Rate By Epinephrine Oxidation-dependent Protein Catabolic Process
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