IFIT3 and LONP1

Number of citations of the paper that reports this interaction (PubMedID 21163940)
58

Data Source:
BioGRID (two hybrid)

		IFIT3	LONP1
Description		interferon induced protein with tetratricopeptide repeats 3	lon peptidase 1, mitochondrial
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol	Nucleoplasm Mitochondrion Mitochondrial Matrix Cytosol Membrane Mitochondrial Nucleoid
	Molecular Function	Protein Binding Identical Protein Binding	Nucleotide Binding Mitochondrial Promoter Sequence-specific DNA Binding DNA Binding Single-stranded DNA Binding Single-stranded RNA Binding ATP-dependent Peptidase Activity Serine-type Endopeptidase Activity Protein Binding ATP Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity ATP Hydrolysis Activity PH Domain Binding Identical Protein Binding ADP Binding Insulin Receptor Substrate Binding Sequence-specific DNA Binding G-quadruplex DNA Binding DNA Polymerase Binding
	Biological Process	Immune System Process Negative Regulation Of Cell Population Proliferation Response To Virus Negative Regulation Of Apoptotic Process Innate Immune Response Defense Response To Virus Antiviral Innate Immune Response	Response To Hypoxia Proteolysis Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Mitochondrion Organization Response To Hormone Response To Aluminum Ion Protein Catabolic Process Mitochondrial DNA Metabolic Process Cellular Response To Oxidative Stress Mitochondrial Protein Catabolic Process Negative Regulation Of Insulin Receptor Signaling Pathway Chaperone-mediated Protein Complex Assembly Proteolysis Involved In Protein Catabolic Process Protein-containing Complex Assembly Oxidation-dependent Protein Catabolic Process
Pathways		Interferon alpha/beta signaling	Mitochondrial protein degradation Mitochondrial unfolded protein response (UPRmt)
Drugs
Diseases
GWAS		Hormone measurements ( 30576415)	Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494) Red cell distribution width ( 32888494)
Interacting Genes		21 interacting genes: A2M ANXA1 APOE CYP2C8 DEUP1 ECSIT FANCA HAUS1 IFIT1 IFIT1B IFIT2 IFIT5 LONP1 LVRN MAST1 PSEN2 RAD23A RNF32 TMEM183A TPM1 TPM3	13 interacting genes: A2M APOE CDC37 CDC42 CYP2C8 ECSIT IFIT3 IFIT5 KEAP1 LOXL4 MAST1 RNF10 RNF32
Entrez ID		3437	9361
HPRD ID		05228	05689
Ensembl ID		ENSG00000119917	ENSG00000196365
Uniprot IDs		A0A7P0T7D6 O14879 Q5T765	P36776
PDB IDs		6C6K	2X36 6WYS 6WZV 6X1M 6X27 7KRZ 7KSL 7KSM 7NFY 7NG4 7NG5 7NGC 7NGF 7NGL 7NGP 7NGQ 7OXO 7P09 7P0B 7P0M 8OJL 8OKA 8OM7 8OVF 8OVG 9CC0 9CC3
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Viral Translation RNA Sequestering Activity Muscle Thin Filament Tropomyosin Regulation Of Viral Process Response To Stress Negative Regulation Of Viral Process Regulation Of Viral Genome Replication Actin Filament Amyloid Precursor Protein Metabolic Process Defense Response To Virus Regulation Of Viral Life Cycle Innate Immune Response Negative Regulation Of Phospholipid Efflux Negative Regulation Of Postsynaptic Membrane Organization Positive Regulation Of Lipid Transport Across Blood-brain Barrier Negative Regulation Of Lipid Transport Across Blood-brain Barrier Regulation Of Cellular Response To Very-low-density Lipoprotein Particle Stimulus Metal Chelating Activity Intermediate-density Lipoprotein Particle Clearance Response To Virus Positive Regulation Of Viral Genome Replication Positive Regulation Of Heart Rate By Epinephrine Oxidation-dependent Protein Catabolic Process
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